Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mirna Pena"'
Autor:
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L. Collins, Susan K. Pierce, Munir Akkaya
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Cerebral malaria (CM), the deadliest complication of Plasmodium infection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental
Externí odkaz:
https://doaj.org/article/3261caae55db47f9969e701fac6f0d4d
Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
Autor:
Emile B. Gordon, Geoffrey T. Hart, Tuan M. Tran, Michael Waisberg, Munir Akkaya, Jeff Skinner, Severin Zinöcker, Mirna Pena, Takele Yazew, Chen-Feng Qi, Louis H. Miller, Susan K. Pierce
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) is a common form of severe malaria resulting in nearly 700,000 deaths each year in Africa alone. At present, there is no adjunctive therapy
Externí odkaz:
https://doaj.org/article/d9d29f731e7d438284e52153462fb045
Autor:
Ivo M B Francischetti, Emile Gordon, Bruna Bizzarro, Nidhi Gera, Bruno B Andrade, Fabiano Oliveira, Dongying Ma, Teresa C F Assumpção, José M C Ribeiro, Mirna Pena, Chen-Feng Qi, Ababacar Diouf, Samuel E Moretz, Carole A Long, Hans C Ackerman, Susan K Pierce, Anderson Sá-Nunes, Michael Waisberg
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87140 (2014)
BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intra
Externí odkaz:
https://doaj.org/article/93b898ae10464641b2643a37ba809973
Autor:
Michael Waisberg, Christina K Lin, Chiung-Yu Huang, Mirna Pena, Marlene Orandle, Silvia Bolland, Susan K Pierce
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62820 (2013)
Severe malaria, including cerebral malaria (CM) and placental malaria (PM), have been recognized to have many of the features of uncontrolled inflammation. We recently showed that in mice genetic susceptibility to the lethal inflammatory autoimmune d
Externí odkaz:
https://doaj.org/article/0ed67994901542f3a109a01a9bc44d3b
Autor:
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L Collins, Susan K. Pierce, Munir Akkaya
Cerebral Malaria (CM), the deadliest complication ofPlasmodiuminfection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental CM (ECM), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48bc41d815ba2f783e94cf8e4f98409
https://doi.org/10.1101/2022.11.23.517617
https://doi.org/10.1101/2022.11.23.517617
Autor:
Billur Akkaya, Pietro Miozzo, Susan K. Pierce, Alexander S. Roesler, Juraj Kabat, Michael N. Sack, Munir Akkaya, Margery G. Smelkinson, Jafar Al Souz, Javier Traba, Joseph Brzostowski, David W. Dorward, Mirna Pena, Brandon P. Theall
Publikováno v:
The Journal of Immunology. 201:3294-3306
Activation of CD4+ T cells to proliferate drives cells toward aerobic glycolysis for energy production while using mitochondria primarily for macromolecular synthesis. In addition, the mitochondria of activated T cells increase production of reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ab2f5d8e115cf69c4765e03c676640d
https://doi.org/10.4049/jimmunol.1800753
https://doi.org/10.4049/jimmunol.1800753
Autor:
Louis H. Miller, Susan K. Pierce, Mirna Pena, Takele Yazew, Chen Feng Qi, Thomas D. Otto, Patrick W. Sheehan, Munir Akkaya, Abhisheka Bansal, Oliver Billker, Clare K. Cimperman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Cerebral malaria (CM) is the deadliest form of severe Plasmodium infections. Currently, we have limited understanding of the mechanisms by which Plasmodium parasites induce CM. The mouse model of CM, experimental CM (ECM), induced by infection with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71da36ba15f86432e5008666d479b3d
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175111
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175111
Autor:
Patrick W. Sheehan, Takele Yazew, Chen Feng Qi, Munir Akkaya, Oliver Billker, Lindsey M. Orchard, Abhisheka Bansal, Louis H. Miller, Susan K. Pierce, Girija Thiruvengadam, Clare K. Cimperman, Philipp Ross, Mirna Pena, Manuel Llinás, Thomas D. Otto, Alvaro Molina-Cruz, Sarah L. Anzick, Daniel E. Sturdevant
Publikováno v:
Science Advances
ApiAP2 transcription factor PBANKA_011210 is a novel Plasmodium virulence factor that blocks induction of host’s immune response.
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about t
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa87937d1b24d5d79ed8755c3517e1b8
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168791
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168791
Autor:
Haewon Sohn, Jeff Skinner, Brandon P. Theall, Mirna Pena, Alexander S. Roesler, Juraj Kabat, Pietro Miozzo, Susan K. Pierce, Jinghua Lu, Ann S. Kim, David W. Dorward, Billur Akkaya, Eric Dahlstrom, Louis H. Miller, Munir Akkaya, Travis Henke
Publikováno v:
Nature immunology
Key events in T cell–dependent antibody responses, including affinity maturation, are dependent on the B cell’s presentation of antigen to helper T cells at critical checkpoints in germinal-center formation in secondary lymphoid organs. Here we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d4990121eaabd17483475ee4f07cf7
https://doi.org/10.1038/s41590-018-0052-z
https://doi.org/10.1038/s41590-018-0052-z
Autor:
Mirna Pena, Susan K. Pierce, Pietro Miozzo, Billur Akkaya, Akanksha Chaturvedi, Olena Kamenyeva, Juraj Kabat, Patrick W. Sheehan, Munir Akkaya, Mukul Rawat, Ann S. Kim, Silvia Bolland
Publikováno v:
The Journal of Immunology. 199:931-940
B cells express the innate receptor, TLR9, which signals in response to unmethylated CpG sequences in microbial DNA. Of the two major classes of CpG-containing oligonucleotides, CpG-A appears restricted to inducing type 1 IFN in innate immune cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aaa13454b0936d4ca04a4fa9e226836
https://doi.org/10.4049/jimmunol.1700348
https://doi.org/10.4049/jimmunol.1700348