Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mirko Zaja"'
Autor:
Mirko Zaja, Filip Vilotic, Gruber Wolfgang, Svetlana Hamm, Elisabeth Peer, Florian Rathje, Sandra Grund-Groeschke, Susanne Michel, Dominik P. Elmer, Sophie Karoline Aichberger, Andrea Ramspacher, Thomas Parigger, Fritz Aberger
(1)BackgroundAberrant activation of the Hedgehog (HH)/GLI pathway in stem-like tumor initiating cells (TIC) is a frequent oncogenic driver signal in various human malignancies. Remarkable efficacy of anti-HH therapeutics led to the approval of HH inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c974e0ac5a8a090f92d797bd468fcc4f
https://doi.org/10.1101/2021.06.17.448773
https://doi.org/10.1101/2021.06.17.448773
Autor:
Lena Stich, Petra Mühl-Zürbes, Christiane Silke Heilingloh, Stefan Strobl, Adalbert Krawczyk, Mirko Zaja, Elisabeth Zinser, Christina Draßner, Alexander Steinkasserer, Ulrich Wilhelm Aufderhorst
Publikováno v:
Antiviral Research. 149:202-210
Infections with Herpes simplex viruses (HSV) belong to the most common human diseases worldwide, resulting in symptoms ranging from painful, but commonly self-limiting lesions of the orofacial or genital tract to severe infections of the eye or life-
Autor:
Daniel Vitt, Johann Leban, Balbina García-Reyes, Sebastian Berg, Joachim Bischof, Mirko Zaja, Irmgard Pospiech, Uwe Knippschild, Vanessa Alscher, Olaf G. Othersen, Hella Kohlhof, Julia Richter
Publikováno v:
Journal of Medicinal Chemistry. 57:7933-7946
Deregulation of CK1 (casein kinase 1) activity can be involved in the development of several pathological disorders and diseases such as cancer. Therefore, research interest in identifying potent CK1-specific inhibitors is still increasing. A previou
Autor:
Jens Milbradt, Christophe Henry, Thomas Stamminger, Hanife Bahsi, Mirko Zaja, Johann Leban, Eric Sonntag, Mirjam Steingruber, William D. Rawlinson, Isabel Zeitträger, Manfred Marschall, Stefan Strobl, Daniel Vitt, Corina Hutterer, Stuart T. Hamilton
Publikováno v:
Antiviral research. 143
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of (val)ganciclovir therapy is hampered by low drug compatibility and induction of viral resistance. A n
Autor:
Wolfgang, Gruber, Martin, Hutzinger, Dominik Patrick, Elmer, Thomas, Parigger, Christina, Sternberg, Lukasz, Cegielkowski, Mirko, Zaja, Johann, Leban, Susanne, Michel, Svetlana, Hamm, Daniel, Vitt, Fritz, Aberger
Publikováno v:
Oncotarget
A wide range of human malignancies displays aberrant activation of Hedgehog (HH)/GLI signaling, including cancers of the skin, brain, gastrointestinal tract and hematopoietic system. Targeting oncogenic HH/GLI signaling with small molecule inhibitors
Autor:
Peter Ney, Marcus Blisse, Philipp Klahn, Udo Quotschalla, Roland Baumgartner, Josef Schachtner, Tanja Wieber, Mirko Zaja, Astrid Ammendola, Sandra Rath, Stefan Tasler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6108-6115
Resulting from a vHTS based on a pharmacophore alignment on known β3-adrenoceptor ligands, an aryloxypropanolamine scaffold comprising a thienopyrimidine moiety was further optimized as a human β3-AR agonist, yielding a lead compound with an excell
Publikováno v:
Advanced Synthesis & Catalysis. 347:1413-1422
A turnover number (TON) study of ruthenium-based metathesis catalysts has been conducted for ring-closing metathesis (RCM) in dilute solution. Unexpectedly the results indicate that 1 s t generation metathesis catalysts can give higher TON in RCM of
Autor:
Siegfried Blechert, Mirko Zaja
Publikováno v:
Tetrahedron. 60:9629-9634
An enantioselective synthesis of the quinolizidine alkaloid (−)-lasubine II 1 is reported. Two different pathways to the key intermediate 2 are described. The first case involving a sequence of ring rearrangement metathesis (RRM), simple functional
Autor:
Siegfried Blechert, Stephen J. Connon, Jan Jiricek, Michael Rivard, Nicole Buschmann, Mirko Zaja, Aideen M. Dunne
Publikováno v:
Tetrahedron. 59:6545-6558
A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesised, and the effects of ligands on the rate of metathesis investigated. Increased steric hinderance ortho to the isopropoxy group enhanced reaction rates
Publikováno v:
Advanced Synthesis & Catalysis. 345:572-575
The discovery that efficient olefin metathesis reactions involving previously challenging terminal olefin substrates are possible using novel and readily available catalyst systems in non-distilled, non-degassed protic media in air is reported.