Výsledky vyhledávání - "Mirko Voelkers"

Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes

Autor: Hugo A. Katus, Natalie Gude, Mark A. Sussman, Patrick Most, Mareen Salz, Derk Frank, Mirko Voelkers, Nima Dolatabadi, Oliver Friedrich, Norbert Frey, Nicole Herzog, Walter J. Koch

Publikováno v: Journal of Molecular and Cellular Cardiology. 48:1329-1334

Cardiac hypertrophy is an independent risk for heart failure (HF) and sudden death. Deciphering signalling pathways dependent on extracellular calcium (Ca(2+)) influx that control normal and pathological cardiac growth may enable identification of no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434ef97c91c8418e73475328be912043
https://doi.org/10.1016/j.yjmcc.2010.01.020

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Abstract 402: Selective Protein Secretion Upon Endoplasmic Reticulum Stress Protects Cardiac Myocytes

Autor: Donna J. Thuerauf, Mirko Voelkers, Shirin Doroudgar, Christopher C. Glembotski, Mirka Stastna, Jennifer E. Van Eyk

Publikováno v: Circulation Research. 117

Protein secretion is important for proper cardiac myocyte function. Many secreted proteins are synthesized and folded in the sarco- endo-plasmic reticulum (SR/ER). A number of diseases, including heart disease, alter the ER in ways that impair ER pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cda25598dffa0186acdbe331ceb4518
https://doi.org/10.1161/res.117.suppl_1.402

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Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells

Autor: Mirko Voelkers, Roberto Alvarez, Silvia Truffa, Anya Y. Joyo, Natalie Gude, Pearl Quijada, Haruhiro Toko, Mark A. Sussman, Veronica Sacchi, Marlo Villanueva, Nirmala Hariharan, Eri Joyo

Publikováno v: Basic Research in Cardiology. 110

Phase I clinical trials applying autologous progenitor cells to treat heart failure have yielded promising results; however, improvement in function is modest, indicating a need to enhance cardiac stem cell reparative capacity. Notch signaling plays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59a2dfc1a90e68e574fa8ee92a3329c
https://doi.org/10.1007/s00395-015-0488-3

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S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes

Autor: Carolin Lerchenmüller, Gang Qiu, Patrick Most, Arjang Ruhparwar, David Rohde, Mirko Voelkers, Nicole Herzog, Hugo A. Katus, Sven T. Pleger, Henriette Brinks, Thierry Carrel, Joseph E. Rabinowitz, Andrea D. Eckhart, Paul J. Mather, Walter J. Koch, Scott C. Silvestry

Publikováno v: Journal of the American College of Cardiology. 58(9)

Objectives This study investigated the hypothesis whether S100A1 gene therapy can improve pathological key features in human failing ventricular cardiomyocytes (HFCMs). Background Depletion of the Ca 2+ -sensor protein S100A1 drives deterioration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b293a975a397f67610c93f4cfe38f7a
https://pubmed.ncbi.nlm.nih.gov/21851888

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S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy

Autor: Melanie Boerries, Gang Qiu, Andrew Remppis, Christian Weidenhammer, Hugo A. Katus, Sven T. Pleger, Patrick Most, David Rohde, Carolin Kraus, Mirko Voelkers

Publikováno v: Journal of molecular and cellular cardiology. 47(4)

Calcium (Ca 2+ ) signaling plays a major role in a wide range of physiological functions including control and regulation of cardiac and skeletal muscle performance and vascular tone [1,2] . As all Ca 2+ signals require proteins to relay intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a42b0222fdb5e1a04b77b4d4aa6af3
https://pubmed.ncbi.nlm.nih.gov/19538970

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Abstract 5326: S100A1 Prevents Arrhythmogenic Diastolic Sarcoplasmic Reticulum Calcium Leak In Ventricular Cardiomyocytes

Autor: Mirko Voelkers, Christian Weidenhammer, Nicole Herzog, Oliver Friedrich, Rainer H Fink, Walter J Koch, Hugo A Katus, Steven S Soltys, Joseph Rabinowitz, Patrick Most

Publikováno v: Circulation. 118

Background: S100A1 is an inotropic calcium (Ca) sensor protein in cardiomyocytes interacting with the cardiac ryanodine receptor (RyR2). Previous studies of our group have shown that S100A1 protein can decrease Ca spark frequency in permeabilized ven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eec42d63f680c6afdd15c8a50400c09e
https://doi.org/10.1161/circ.118.suppl_18.s_527-a

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Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy

Autor: Hans-Joerg Hippe, Maike Knorr, Norbert Frey, Christina Grundt, Benedikt Brors, Bjoern Lemmer, Hugo A. Katus, Mirko Voelkers, Patrick Most, Mark Luedde, Derk Frank, Ulrich Flögel, Claude Antony, Uta Haselmann, J. Schrader

Publikováno v: Journal of molecular medicine (Berlin, Germany). 87(4)

Hypertrophic cardiomyopathy (HCM) is associated with cardiac hypertrophy, diastolic dysfunction, and sudden death. Recently, it has been suggested that inefficient energy utilization could be a common molecular pathway of HCM-related mutations. We ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c40766162ec20b0b225c3a275ba2ad
https://pubmed.ncbi.nlm.nih.gov/19189074

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