Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mirko Völkers"'
Autor:
Natali Froese, Julio Cordero, Aya Abouissa, Felix A. Trogisch, Steve Grein, Malgorzata Szaroszyk, Yong Wang, Anna Gigina, Mortimer Korf-Klingebiel, Berislav Bosnjak, Colin F. Davenport, Lutz Wiehlmann, Robert Geffers, Eva Riechert, Lonny Jürgensen, Etienne Boileau, Yanzhu Lin, Christoph Dieterich, Reinhold Förster, Johann Bauersachs, Roxana Ola, Gergana Dobreva, Mirko Völkers, Joerg Heineke
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103965- (2022)
Summary: To identify cellular mechanisms responsible for pressure overload triggered heart failure, we isolated cardiomyocytes, endothelial cells, and fibroblasts as most abundant cell types from mouse hearts in the subacute and chronic stages after
Externí odkaz:
https://doaj.org/article/6224cc5550424983837de122401cc858
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/4e82bc812ae245839eb79152cd77315c
Autor:
Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers, Christoph Dieterich
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/ad5a3ba94d9f445bb3968bc96f6350f7
Autor:
Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf‐Klingebiel, Mona Malek Mohammadi, Felix A Trogisch, Ulrike Schrameck, Anna Gigina, Christopher Tiedje, Matthias Gaestel, Theresia Kraft, Jan Hegermann, Sandor Batkai, Thomas Thum, Andreas Perrot, Cris dos Remedios, Eva Riechert, Mirko Völkers, Shirin Doroudgar, Andreas Jungmann, Ralf Bauer, Xiaoke Yin, Manuel Mayr, Kai C Wollert, Andreas Pich, Hua Xiao, Hugo A Katus, Johann Bauersachs, Oliver J Müller, Joerg Heineke
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-20 (2019)
Abstract Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically, the identification of negative regulators of cardiomyocyte protein synthesis is n
Externí odkaz:
https://doaj.org/article/f9470b276260446599ccfd463aeb960b
Autor:
Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers, Christoph Dieterich
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Our understanding of the transition from physiological to pathological cardiac hypertrophy remains elusive and largely based on reductionist hypotheses. Here, we profiled the translatomes of 15 mouse hearts to provide a molecular blueprint of altered
Externí odkaz:
https://doaj.org/article/1a54f472e8994a88ac56e09d6cb0906a
Autor:
Jan Haas, Stefan Mester, Alan Lai, Karen S Frese, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Tobias Rausch, Rouven Nietsch, Jes‐Niels Boeckel, Avisha Carstensen, Mirko Völkers, Carsten Dietrich, Dietmar Pils, Ali Amr, Daniel B Holzer, Diana Martins Bordalo, Daniel Oehler, Tanja Weis, Derliz Mereles, Sebastian Buss, Eva Riechert, Emil Wirsz, Maximilian Wuerstle, Jan O Korbel, Andreas Keller, Hugo A Katus, Andreas E Posch, Benjamin Meder
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 107-120 (2017)
Abstract The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes i
Externí odkaz:
https://doaj.org/article/4481e23c5007408586f68c9d973d8b8f
Autor:
Matthias Eden, Benjamin Meder, Mirko Völkers, Montatip Poomvanicha, Katrin Domes, M. Branchereau, P. Marck, Rainer Will, Alexander Bernt, Ashraf Rangrez, Matthias Busch, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Christophe Heymes, Wolfgang Rottbauer, Patrick Most, Franz Hofmann, Norbert Frey
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel
Externí odkaz:
https://doaj.org/article/be1c405ffde14645b9a55bd92869f64e
Autor:
David Rohde, Christoph Schön, Melanie Boerries, Ieva Didrihsone, Julia Ritterhoff, Katharina F Kubatzky, Mirko Völkers, Nicole Herzog, Mona Mähler, James N Tsoporis, Thomas G Parker, Björn Linke, Evangelos Giannitsis, Erhe Gao, Karsten Peppel, Hugo A Katus, Patrick Most
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 6, Pp 778-794 (2014)
Abstract Members of the S100 protein family have been reported to function as endogenous danger signals (alarmins) playing an active role in tissue inflammation and repair when released from necrotic cells. Here, we investigated the role of S100A1, t
Externí odkaz:
https://doaj.org/article/ff846c34416d4f4cb43abf84a007e51f
Autor:
Mirko Völkers, Shirin Doroudgar, Nathalie Nguyen, Mathias H Konstandin, Pearl Quijada, Shabana Din, Luis Ornelas, Donna J Thuerauf, Natalie Gude, Kilian Friedrich, Stephan Herzig, Christopher C Glembotski, Mark A Sussman
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 1, Pp 57-65 (2013)
Abstract Diabetes is a multi‐organ disease and diabetic cardiomyopathy can result in heart failure, which is a leading cause of morbidity and mortality in diabetic patients. In the liver, insulin resistance contributes to hyperglycaemia and hyperli
Externí odkaz:
https://doaj.org/article/e698196cef0545a59a875f2c42ac7ff5
Autor:
Daniel Scherer, Claudia Seyler, Panagiotis Xynogalos, Eberhard P Scholz, Dierk Thomas, Johannes Backs, Martin Andrassy, Mirko Völkers, Christoph A Karle, Hugo A Katus, Edgar Zitron
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156181 (2016)
Cardiac inwardly rectifying Kir current (IK1) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 an
Externí odkaz:
https://doaj.org/article/81ae8decf0344b72bfca4cd321729931