Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mirko Theis"'
Autor:
Yusuke Toyoda, Cedric J. Cattin, Martin P. Stewart, Ina Poser, Mirko Theis, Teymuras V. Kurzchalia, Frank Buchholz, Anthony A. Hyman, Daniel J. Müller
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
During cell division animal cells generate intracellular pressure and round against their environment, but the genes responsible for this are largely unknown. Here the authors use a microcantilever- and RNAi-based assay to screen > 1000 genes and ide
Externí odkaz:
https://doaj.org/article/e90be210e50b44a588340bc826ea3fc6
Autor:
Maria Winzi, Nuria Casas Vila, Maciej Paszkowski-Rogacz, Li Ding, Svenja Noack, Mirko Theis, Falk Butter, Frank Buchholz
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191682 (2018)
RNA interference (RNAi) screens have been shown to be valuable to study embryonic stem cell (ESC) self-renewal and they have been successfully applied to identify coding as well as noncoding genes required for maintaining pluripotency. Here, we used
Externí odkaz:
https://doaj.org/article/ab3bb76e23024355b556833cbeff99d4
An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression.
Autor:
Marc Leushacke, Ralf Spörle, Christof Bernemann, Antje Brouwer-Lehmitz, Johannes Fritzmann, Mirko Theis, Frank Buchholz, Bernhard G Herrmann, Markus Morkel
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23381 (2011)
In tumor cells, stepwise oncogenic deregulation of signaling cascades induces alterations of cellular morphology and promotes the acquisition of malignant traits. Here, we identified a set of 21 genes, including FGF9, as determinants of tumor cell mo
Externí odkaz:
https://doaj.org/article/61c4d04199884c3696add6a3c54a6b40
Autor:
Mikołaj Słabicki, Mirko Theis, Dragomir B Krastev, Sergey Samsonov, Emeline Mundwiller, Magno Junqueira, Maciej Paszkowski-Rogacz, Joan Teyra, Anne-Kristin Heninger, Ina Poser, Fabienne Prieur, Jérémy Truchetto, Christian Confavreux, Cécilia Marelli, Alexandra Durr, Jean Philippe Camdessanche, Alexis Brice, Andrej Shevchenko, M Teresa Pisabarro, Giovanni Stevanin, Frank Buchholz
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000408 (2010)
DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are frequently mutated in a variety of human diseases. Repair via homologous recombination typically restores the original DNA sequence without introducing mutat
Externí odkaz:
https://doaj.org/article/f5f2a05ab4b94ace913261bc60a1e2dd
Autor:
Sara Vanessa Bernhard, Katarzyna Seget-Trzensiok, Christian Kuffer, Dragomir B. Krastev, Lisa-Marie Stautmeister, Mirko Theis, Kristina Keuper, Jan-Eric Boekenkamp, Maik Kschischo, Frank Buchholz, Zuzana Storchova
Publikováno v:
Cellular oncology
Background Whole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal instability. Yet, erroneously arising human tetraploid cells usually do not proliferate due to p53 activati
Autor:
Li Ding, Lukas Theo Schmitt, Melanie Brux, Duran Sürün, Martina Augsburg, Felix Lansing, Jovan Mircetic, Mirko Theis, Frank Buchholz
Publikováno v:
Life Science Alliance. 5:e202101321
The programmable CRISPR/Cas9 DNA nuclease is a versatile genome editing tool, but it requires the host cell DNA repair machinery to alter genomic sequences. This fact leads to unpredictable changes of the genome at the cut sites. Genome editing tools
Autor:
Frank Momburg, Mirko Theis, Marietta Döring, Marten Meyer, Frank Buchholz, Maciej Paszkowski-Rogacz, Carolina Blanck, Sandeep Sreevalsan, Melanie Brux
Publikováno v:
EMBO Reports
Tumor cells subvert immune surveillance by harnessing signals from immune checkpoints to acquire immune resistance. The protein PD‐L1 is an important component in this process, and inhibition of PD‐L1 elicits durable anti‐tumor responses in a b
Autor:
Jan-Eric Boekenkamp, Mirko Theis, Katarzyna Seget-Trzensiok, Zuzana Storchova, Dragomir B Krastev, Kristina Keuper, Sara Vanessa Bernhard, Maik Kschischo, Frank Buchholz, Christian Kuffer
Tetraploidy is frequent in cancer and whole genome doubling shapes the evolution of cancer genomes, thereby driving the transformation, metastasis and drug resistance. Yet, human cells usually arrest when they become tetraploid due to p53 activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36a59eb486d17b90494b58378a5fe902
https://doi.org/10.1101/2020.09.18.303834
https://doi.org/10.1101/2020.09.18.303834
Autor:
A. Francis Stewart, Matthias Mann, Ina Poser, Li Ding, Nevan J. Krogan, Debojyoti Chakraborty, Maria Winzi, Assen Roguev, Maciej Paszkowski-Rogacz, Giovanni Ciotta, Wai Kit Chu, Chunaram Choudhary, Mirko Theis, Frank Buchholz, Sukhdeep Singh
Publikováno v:
Cell Systems. 1:141-151
SummaryWe combine a genome-scale RNAi screen in mouse epiblast stem cells (EpiSCs) with genetic interaction, protein localization, and “protein-level dependency” studies—a systematic technique that uncovers post-transcriptional regulation—to
Autor:
Falk Butter, Li Ding, Mirko Theis, Maria Winzi, Nuria Casas Vila, Frank Buchholz, Svenja Noack, Maciej Paszkowski-Rogacz
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0191682 (2018)
PLoS ONE, Vol 13, Iss 1, p e0191682 (2018)
RNA interference (RNAi) screens have been shown to be valuable to study embryonic stem cell (ESC) self-renewal and they have been successfully applied to identify coding as well as noncoding genes required for maintaining pluripotency. Here, we used