Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mirko Ronzio"'
Autor:
Michela Londero, Alberto Gallo, Camilla Cattaneo, Anna Ghilardi, Mirko Ronzio, Luca Del Giacco, Roberto Mantovani, Diletta Dolfini
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract NF-Y is a trimeric transcription factor whose binding site -the CCAAT box- is enriched in cancer-promoting genes. The regulatory subunit, the sequence-specificity conferring NF-YA, comes in two major isoforms, NF-YA long (NF-YAl) and short (
Externí odkaz:
https://doaj.org/article/a6aa830ce579401eaa22fd41289e8a96
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract NF-Y is a pioneer transcription factor—TF—formed by the Histone-like NF-YB/NF-YC subunits and the regulatory NF-YA. It binds to the CCAAT box, an element enriched in promoters of genes overexpressed in many types of cancer. NF-YA is pres
Externí odkaz:
https://doaj.org/article/63ee7c7ba20644038167b8ceaf633f50
Autor:
Silvia Belluti, Valentina Semeghini, Giovanna Rigillo, Mirko Ronzio, Daniela Benati, Federica Torricelli, Luca Reggiani Bonetti, Gianluca Carnevale, Giulia Grisendi, Alessia Ciarrocchi, Massimo Dominici, Alessandra Recchia, Diletta Dolfini, Carol Imbriano
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-23 (2021)
Abstract Background Approaches based on expression signatures of prostate cancer (PCa) have been proposed to predict patient outcomes and response to treatments. The transcription factor NF-Y participates to the progression from benign epithelium to
Externí odkaz:
https://doaj.org/article/4a0867c853ee44289ffbdfc913f11aa3
Autor:
Giovanna Rigillo, Valentina Basile, Silvia Belluti, Mirko Ronzio, Elisabetta Sauta, Alessia Ciarrocchi, Lucia Latella, Marielle Saclier, Susanna Molinari, Antonio Vallarola, Graziella Messina, Roberto Mantovani, Diletta Dolfini, Carol Imbriano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Satellite cells represent myogenic stem cells that allow the homeostasis and repair of adult skeletal muscle. Here the authors report that the transcription factor NF-Y is expressed in satellite cells and is important for their maintenance and proper
Externí odkaz:
https://doaj.org/article/c7e52b79019b4f318074386e94b4dd9f
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008488 (2020)
NF-Y is a trimeric Transcription Factor -TF- which binds with high selectivity to the conserved CCAAT element. Individual ChIP-seq analysis as well as ENCODE have progressively identified locations shared by other TFs. Here, we have analyzed data int
Externí odkaz:
https://doaj.org/article/e2ebf8eaac7441e3b83d89ac19a8b050
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Chromatin immunoprecipitation followed by next-generation sequencing (ChIP-Seq) has opened new avenues of research in the genome-wide characterization of regulatory DNA-protein interactions at the genetic and epigenetic level. As a consequence, it ha
Externí odkaz:
https://doaj.org/article/1b5652cba576483aadee17c3d508fa4d
Autor:
Eugenia Bezzecchi, Andrea Bernardini, Mirko Ronzio, Claudia Miccolo, Susanna Chiocca, Diletta Dolfini, Roberto Mantovani
Publikováno v:
Cancers, Vol 13, Iss 12, p 3019 (2021)
NF-Y is the CCAAT-binding trimer formed by the histone fold domain (HFD), NF-YB/NF-YC and NF-YA. The CCAAT box is generally prevalent in promoters of “cancer” genes. We reported the overexpression of NF-YA in BRCA, LUAD and LUSC, and of all subun
Externí odkaz:
https://doaj.org/article/1d26dd3a4c024875a9deb357b5c523b6
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9157 (2020)
NF-Y is a pioneer trimeric transcription factor formed by the Histone Fold Domain (HFD) NF-YB/NF-YC subunits and NF-YA. Three subunits are required for DNA binding. CCAAT-specificity resides in NF-YA and transactivation resides in Q-rich domains of N
Externí odkaz:
https://doaj.org/article/24fef3de0d1d4d97b06147e2d404b5af
Autor:
Eugenia Bezzecchi, Mirko Ronzio, Valentina Semeghini, Valentina Andrioletti, Roberto Mantovani, Diletta Dolfini
Publikováno v:
Genes, Vol 11, Iss 2, p 198 (2020)
The trimeric transcription factor (TF) NF-Y regulates the CCAAT box, a DNA element enriched in promoters of genes overexpressed in many types of cancer. The regulatory NF-YA is present in two major isoforms, NF-YAl (“long”) and NF-YAs (“short
Externí odkaz:
https://doaj.org/article/2877326cbcbd48a6afae5e94a405e94b
Publikováno v:
Genes, Vol 10, Iss 11, p 937 (2019)
The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl (“long”) and NF-YAs (“short”). Little is known about the expression levels of NF-Y subunits in tumors
Externí odkaz:
https://doaj.org/article/374c9b5a0f4141aeb92915c8e3086dc5