Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mirko M, Maksimainen"'
Autor:
Dr. Patricia Korn, Arno Classen, Dr. Sudarshan Murthy, Dr. Riccardo Guareschi, Mirko M. Maksimainen, Barbara E. Lippok, Albert Galera‐Prat, Sven T. Sowa, Catharina Voigt, Prof. Dr. Giulia Rossetti, Prof. Dr. Lari Lehtiö, Prof. Dr. Carsten Bolm, Prof. Dr. Bernhard Lüscher
Publikováno v:
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
Abstract Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The mono‐ADP‐ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies ide
Externí odkaz:
https://doaj.org/article/0e125f0171b24e93b9aec1f09fcdc7ff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a crystal structure of PARP2 bound to an activating DNA fragment, providing insights in
Externí odkaz:
https://doaj.org/article/3e12a12ec89744fea3a04b2b30548e8f
Autor:
Sven T. Sowa, Albert Galera-Prat, Sarah Wazir, Heli I. Alanen, Mirko M. Maksimainen, Lari Lehtiö
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101147- (2022)
Summary: Here, we describe a protocol to set up a screening assay for ADP-ribosyl binding proteins including proteins that possess O-glycosidase or N-glycosidase activities. The FRET-based assay measures the interaction of any ADP-ribosyl binding pro
Externí odkaz:
https://doaj.org/article/5757d53f46f04a1595194b95e88c4132
Autor:
Mirko M. Maksimainen, Antti Nurmesjärvi, Reima A. Terho, Michael D. Threadgill, Lari Lehtiö, Juha P. Heiskanen
Publikováno v:
ACS Omega, Vol 5, Iss 22, Pp 13447-13453 (2020)
Externí odkaz:
https://doaj.org/article/43bf483d33bf4b5f96712abac7d635da
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0223870 (2020)
Lactate oxidases belong to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Hydrogen peroxide is also utilized as a read out in biosensors to quantitate lactate levels in biol
Externí odkaz:
https://doaj.org/article/d6bff684775d40468d3bd47bfcf7a10d
Publikováno v:
Journal of Medicinal Chemistry. 65:7532-7560
Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82dc894f3804d28dd39e28876301931
https://doi.org/10.1021/acs.jmedchem.2c00281
https://doi.org/10.1021/acs.jmedchem.2c00281
Autor:
Sudarshan, Murthy, Maria Giulia, Nizi, Mirko M, Maksimainen, Serena, Massari, Juho, Alaviuhkola, Barbara E, Lippok, Chiara, Vagaggini, Sven T, Sowa, Albert, Galera-Prat, Yashwanth, Ashok, Harikanth, Venkannagari, Renata, Prunskaite-Hyyryläinen, Elena, Dreassi, Bernhard, Lüscher, Patricia, Korn, Oriana, Tabarrini, Lari, Lehtiö
Publikováno v:
Journal of medicinal chemistry.
We report [1,2,4]triazolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7842b39c06010b4651f7dd439c1106f
https://pubmed.ncbi.nlm.nih.gov/36598465
https://pubmed.ncbi.nlm.nih.gov/36598465
Autor:
Sudarshan Murthy, Maria Giulia Nizi, Mirko M. Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
Publikováno v:
Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Published by American Chemical Society, Washington, DC
Published by American Chemical Society, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c78b88c3e04c15acc5405940609a1
http://urn.fi/urn:nbn:fi-fe2023032232837
http://urn.fi/urn:nbn:fi-fe2023032232837
Autor:
Patricia Korn, Lari Lehtiö, Bernhard Lüscher, Sven T. Sowa, Arno Classen, Giulia Rossetti, Barbara E. Lippok, Mirko M. Maksimainen, Carsten Bolm, Riccardo Guareschi, Albert Galera-Prat, Sudarshan Murthy, Catharina Voigt
Publikováno v:
ChemistryOpen
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
ChemistryOpen : including thesis treasury 10(10), 939-948 (2021). doi:10.1002/open.202100087
ChemistryOpen 10(10), 939-948 (2021). doi:10.1002/open.202100087
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
ChemistryOpen : including thesis treasury 10(10), 939-948 (2021). doi:10.1002/open.202100087
ChemistryOpen 10(10), 939-948 (2021). doi:10.1002/open.202100087
Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The mono‐ADP‐ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies identified O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc19aa514ce4edf140f761373ebc5713
http://europepmc.org/articles/PMC8485830
http://europepmc.org/articles/PMC8485830
Publikováno v:
Acta Crystallogr F Struct Biol Commun
MacroD2 is one of the three human macrodomain proteins characterized by their protein-linked mono-ADP-ribosyl-hydrolyzing activity. MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove. In this study, new crystallization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7aa0b7f881b5ced183e518fff2295
https://doi.org/10.1107/s2053230x20011309
https://doi.org/10.1107/s2053230x20011309