Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mirko Kummer"'
Autor:
Elias A. T. Koch, Niels Schaft, Mirko Kummer, Carola Berking, Gerold Schuler, Kenichiro Hasumi, Jan Dörrie, Beatrice Schuler-Thurner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Uveal melanoma (UM) is an orphan disease with a mortality of 80% within one year upon the development of metastatic disease. UM does hardly respond to chemotherapy and kinase inhibitors and is largely resistant to checkpoint inhibition. Hence, furthe
Externí odkaz:
https://doaj.org/article/6472911da671458fa687e220434108be
Autor:
Stephan Klessing, Antonia Sophia Peter, Kirsten Fraedrich, Jannik T. Wagner, Mirko Kummer, Janina Deutschmann, Philipp Steininger, Hans-Dieter Steibl, Klaus Überla
Publikováno v:
Viruses, Vol 15, Iss 2, p 397 (2023)
Live-attenuated SARS-CoV-2 vaccines present themselves as a promising approach for the induction of broad mucosal immunity. However, for initial safety assessment in clinical trials, virus production requires conditions meeting Good Manufacturing Pra
Externí odkaz:
https://doaj.org/article/cef303dff024458ca4eb53d2e12b97eb
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
HSV-1 is a very successful human pathogen, known for its high sero-prevalence and the ability to infect a wide range of different cell types, including dendritic cells (DCs). As very potent antigen-presenting cells DCs play an important role in the i
Externí odkaz:
https://doaj.org/article/ce6dc2f1bd784843be0b68499996eb3a
Autor:
Caroline Voskens, Diane Stoica, Marita Rosenberg, Francesco Vitali, Sebastian Zundler, Marion Ganslmayer, Heike Knott, Manuel Wiesinger, Jutta Wunder, Mirko Kummer, Britta Siegmund, Elisabeth Schnoy, Timo Rath, Arndt Hartmann, Holger Hackstein, Beatrice Schuler-Thurner, Carola Berking, Gerold Schuler, Raja Atreya, Markus F Neurath
ObjectiveUlcerative colitis (UC) is a chronic, debilitating immune-mediated disease driven by disturbed mucosal homeostasis, with an excess of intestinal effector T cells and an insufficient expansion of mucosal regulatory T cells (Tregs). We here re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aee86c89ff90a5fd010dbd91715853
https://opus4.kobv.de/opus4-fau/files/21116/gutjnl-72-49.pdf
https://opus4.kobv.de/opus4-fau/files/21116/gutjnl-72-49.pdf
Autor:
Holger Jastrow, Beate Sodeik, Christiane Silke Heilingloh, Katinka Döhner, Aykut Turan, Alexandra Düthorn, Mirko Kummer, Sylvia Voortmann, Christina Drassner, Niels Schaft, Alexander Steinkasserer, Petra Mühl-Zürbes, Jan Dörrie, Mike Hasenberg, Adalbert Krawczyk, Max E. Kraner, Linda Grosche
Publikováno v:
The Journal of Cell Biology
Florence Niedergang introduces work by Turan et al. demonstrating that herpes virus egress from dendritic cells is differentially regulated by kinesin-dependent positioning of lysosomes and autophagic degradation of nuclear lamins.
Herpes simple
Herpes simple
Autor:
Marcello F. Stein, Alexander Steinkasserer, Brigitte Biesinger, Heinrich Sticht, Katja Blume, Mirko Kummer, Christiane Silke Heilingloh
Publikováno v:
Biochemical and Biophysical Research Communications. 459:42-48
CD83 is one of the best known surface markers for mature human dendritic cells (DCs). The full-length 45 kDa type-I membrane-bound form (mbCD83) is strongly glycosylated upon DCs maturation. As co-stimulatory properties of CD83 are attributed to mbCD
Publikováno v:
Journal of General Virology. 95:1366-1375
Mature dendritic cells (mDCs) are the most potent antigen-presenting cells known today, as they are the only antigen-presenting cells able to induce naïve T-cells. Therefore, they play a crucial role during the induction of effective antiviral immun
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1499
Uveal melanoma is the most frequently occurring primary intraocular tumor in adults, with an incidence of about 5 out of 100,000 per year, the incidence rising with increasing age (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin
Autor:
Beatrice Schuler-Thurner, Mirko Kummer
Publikováno v:
RNA Vaccines ISBN: 9781493964796
Uveal melanoma is the most frequently occurring primary intraocular tumor in adults, with an incidence of about 5 out of 100,000 per year, the incidence rising with increasing age (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344f0cafdf67e5a16aac1b4b2c52b3fe
https://doi.org/10.1007/978-1-4939-6481-9_17
https://doi.org/10.1007/978-1-4939-6481-9_17
Autor:
Yves A. Muller, Heinrich Sticht, Stefan Klingl, Alexander Steinkasserer, Christiane Silke Heilingloh, Benedikt Schmid, Mirko Kummer, Petra Mühl-Zürbes, Sigrid Weiler, Jörg Hofmann, Claudia Egerer-Sieber, Joachim D. Stump
Publikováno v:
Journal of molecular biology. 429(8)
CD83 is a type-I membrane protein and an efficient marker for identifying mature dendritic cells. Whereas membrane-bound, full-length CD83 co-stimulates the immune system, a soluble variant (sCD83), consisting of the extracellular domain only, displa