Výsledky vyhledávání - "Mirko Klingauf"

Acoustophoretic contactless transport and handling of matter in air

Autor: Daniele Foresti, Majid Nabavi, Mirko Klingauf, Aldo Ferrari, Dimos Poulikakos

Publikováno v: Proceedings of the National Academy of Sciences. 110:12549-12554

Levitation and controlled motion of matter in air have a wealth of potential applications ranging from materials processing to biochemistry and pharmaceuticals. We present a unique acoustophoretic concept for the contactless transport and handling of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7df697f285937b2e92b930926aa551
https://doi.org/10.1073/pnas.1301860110

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The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration

Autor: Peter Horvath, Stephan Heinzer, M. Beck, Ulrich Berge, Yagmur Turgay, Ruth Kroschewski, Mirko Klingauf

Publikováno v: Biology of the Cell. 105:91-107

Background information The mitogenic pathway, composed of RAF kinases, mitogen-activated protein kinase kinases (MEK) and extracellular signal-regulated kinases (ERK), promotes cell proliferation and migration and is upregulated in many tumours. DiRa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfffbd57dc9a6d97cb63187afea7f9f3
https://doi.org/10.1111/boc.201200030

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Sub-micron lateral topography affects endothelial migration by modulation of focal adhesion dynamics

Autor: Sara Antonini, Sandro Meucci, Mirko Klingauf, Fabio Beltram, Aldo Ferrari, Dimos Poulikakos, Marco Cecchini, Emanuela Jacchetti

Publikováno v: Biomedical materials (Online) 10 (2015). doi:10.1088/1748-6041/10/3/035010
info:cnr-pdr/source/autori:Antonini S.; Meucci S.; Jacchetti E.; Klingauf M.; Beltram F.; Poulikakos D.; Cecchini M.; Ferrari A./titolo:Sub-micron lateral topography affects endothelial migration by modulation of focal adhesion dynamics/doi:10.1088%2F1748-6041%2F10%2F3%2F035010/rivista:Biomedical materials (Online)/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume:10

Through the interaction with topographical features, endothelial cells tune their ability to populate target substrates, both in vivo and in vitro. Basal textures interfere with the establishment and maturation of focal adhesions (FAs) thus inducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0283a15585b21196082acb8c9872dfa0
https://pubmed.ncbi.nlm.nih.gov/26106866

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On cell separation with topographically engineered surfaces

Autor: Davide, Franco, Mirko, Klingauf, Marco, Cecchini, Volkmar, Falk, Christoph, Starck, Dimos, Poulikakos, Aldo, Ferrari

Publikováno v: Biointerphases. 8(1)

Topographical modifications of the surface influence several cell functions and can be exploited to modulate cellular activities such as adhesion, migration and proliferation. These complex interactions are cell-type specific, therefore engineered su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46a8bc516ef11b930b786f6d81240b19
https://pubmed.ncbi.nlm.nih.gov/24706142

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Control of initial endothelial spreading by topographic activation of focal adhesion kinase

Autor: Martin Bednarzik, Jens Gobrecht, Davide Franco, Dimos Poulikakos, Marco Cecchini, Mirko Klingauf, Aldo Ferrari, Vartan Kurtcuoglu

Publikováno v: Soft matter
7 (2011): 7313–7324. doi:10.1039/c1sm05191a
info:cnr-pdr/source/autori:Franco D.; Klingauf M.; Bednarzik M.; Cecchini M.; Kurtcuoglu V.; Gobrecht J.; Poulikakos D.; Ferrari A./titolo:Control of initial endothelial spreading by topographic activation of focal adhesion kinase/doi:10.1039%2Fc1sm05191a/rivista:Soft matter (Print)/anno:2011/pagina_da:7313/pagina_a:7324/intervallo_pagine:7313–7324/volume:7

The time required to re-establish a functioning endothelial cell layer after vascular implant placement is critical to the success of the respective cardiologic or surgical intervention. Topographic modifications of implant surfaces promise to expedi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3ecebd1f1ccf8f62c16e72e3e5dc34
http://www.scopus.com/inward/record.url?eid=2-s2.0-79961133379&partnerID=q2rCbXpz

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Microfluidic chip for spatially and temporally controlled biochemical gradient generation in standard cell-culture Petri dishes

Autor: Aldo Ferrari, Piero Castrataro, Vincenzo Lionetti, Marco Cecchini, Arianna Menciassi, Ranjana Sahai, Fabio Beltram, Mirko Klingauf, Chiara Martino

Publikováno v: Microfluidics and nanofluidics
11 (2011): 763–771. doi:10.1007/s10404-011-0841-2
info:cnr-pdr/source/autori:Sahai, Ranjana; Cecchini, Marco; Klingauf, Mirko; Ferrari, Aldo; Martino, Chiara; Castrataro, Piero; Lionetti, Vincenzo; Menciassi, Arianna; Beltram, Fabio/titolo:Microfluidic chip for spatially and temporally controlled biochemical gradient generation in standard cell-culture Petri dishes/doi:10.1007%2Fs10404-011-0841-2/rivista:Microfluidics and nanofluidics (Print)/anno:2011/pagina_da:763/pagina_a:771/intervallo_pagine:763–771/volume:11
Microfluidics and Nanofluidics

This paper reports the development, modeling, and testing of an original microfluidic chip capable of generating both time-evolving and spatially varying gradients in standard Petri dishes. It consists of three sets of five independently controlled p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb4842e1c527db5760d10da24ccbf10
https://hdl.handle.net/11384/6736

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Enhancement of U4/U6 Small Nuclear Ribonucleoprotein Particle Association in Cajal Bodies Predicted by Mathematical Modeling

Autor: Karla M. Neugebauer, Mirko Klingauf, David Stanek

Spliceosomal small nuclear ribonucleoprotein particles (snRNPs) undergo specific assembly steps in Cajal bodies (CBs), nonmembrane-bound compartments within cell nuclei. An example is the U4/U6 di-snRNP, assembled from U4 and U6 monomers. These snRNP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6717129562ca02cbb5919f915a19c9
https://europepmc.org/articles/PMC1679666/

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IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway

Autor: Dominique Didry, Christophe Le Clainche, Mirko Klingauf, Coumaran Egile, Dominik Schlaepfer, Alexey Veligodskiy, Diep Le, Ruth Kroschewski, Katarina Grohmanova, Marie-France Carlier, Aldo Ferrari

Publikováno v: The Journal of biological chemistry. 282(1)

IQGAP1 is a conserved modular protein overexpressed in cancer and involved in organizing actin and microtubules in motile processes such as adhesion, migration, and cytokinesis. A variety of proteins have been shown to interact with IQGAP1, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cb8d042c32b7e72a4d1160b2a64166
https://pubmed.ncbi.nlm.nih.gov/17085436

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Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies

Autor: Stephen D. Rader, Karla M. Neugebauer, Mirko Klingauf, David Stanek

Publikováno v: The Journal of Cell Biology

The spliceosomal small nuclear RNAs (snRNAs) are distributed throughout the nucleoplasm and concentrated in nuclear inclusions termed Cajal bodies (CBs). A role for CBs in the metabolism of snRNPs has been proposed but is not well understood. The SAR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d834488a17ce4e3c909fe08046ae774
https://pubmed.ncbi.nlm.nih.gov/12578909

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