Výsledky vyhledávání - "Mirko Glinski"

The cAMP Capture Compound Mass Spectrometry as a Novel Tool for Targeting cAMP-binding Proteins

Autor: Yan Luo, Mathias Dreger, Michael Sefkow, Hubert Köster, Christian Blex, Mirko Glinski, Olivia Baessler

Publikováno v: Molecular & Cellular Proteomics. 8:2843-2856

The profiling of subproteomes from complex mixtures on the basis of small molecule interactions shared by members of protein families or small molecule interaction domains present in a subset of proteins is an increasingly important approach in funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77b3d5926b3875df923989ce3b6c7ac4
https://doi.org/10.1074/mcp.m900110-mcp200

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Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs

Autor: Anna K. Schrey, Simon Michaelis, Hubert Koester, Friedrich Kroll, Mathias Dreger, Jenny J. Fischer, Olivia Baessler, Mirko Glinski

Publikováno v: Toxicological Sciences. 113:243-253

Capture compound mass spectrometry (CCMS) is a novel technology that helps understand the molecular mechanism of the mode of action of small molecules. The Capture Compounds are trifunctional probes: A selectivity function (the drug) interacts with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189f470205ac9fc49c08291b6fe48e29
https://doi.org/10.1093/toxsci/kfp236

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Absolute quantification of Medicago truncatula sucrose synthase isoforms and N-metabolism enzymes in symbiotic root nodules and the detection of novel nodule phosphoproteins by mass spectrometry

Autor: Mirko Glinski, Esther M. González, Wolfram Weckwerth, Estíbaliz Larrainzar, Cesar Arrese-Igor, Stefanie Wienkoop

Publikováno v: Journal of Experimental Botany

Mass spectrometry (MS) has become increasingly important for tissue specific protein quantification at the isoform level, as well as for the analysis of protein post-translational regulation mechanisms and turnover rates. Thanks to the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e3538c3834d23ac263e52cc8966684
http://europepmc.org/articles/PMC2529246

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The role of mass spectrometry in plant systems biology

Autor: Wolfram Weckwerth, Mirko Glinski

Publikováno v: Mass Spectrometry Reviews. 25:173-214

Large-scale analyses of proteins and metabolites are intimately bound to advancements in MS technologies. The aim of these non-targeted "omic" technologies is to extend our understanding beyond the analysis of only parts of the system. Here, metabolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a146c60d65bbb167451d790b506e78d7
https://doi.org/10.1002/mas.20063

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Differential Multisite Phosphorylation of the Trehalose-6-phosphate Synthase Gene Family in Arabidopsis thaliana

Autor: Mirko Glinski, Wolfram Weckwerth

Publikováno v: Molecular & Cellular Proteomics. 4:1614-1625

Multisite protein phosphorylation plays a fundamental role in metabolic regulation. To detect and quantify in vitro kinase phosphorylation activities, we developed a highly selective LC-MS/MS-based method using high resolution multiple reaction monit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::391510d993de02b4f36f93fb702e7d88
https://doi.org/10.1074/mcp.m500134-mcp200

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An integrated strategy for identification and relative quantification of site-specific protein phosphorylation using liquid chromatography coupled to MS2/MS3

Autor: Ute Lehmann, Wolfram Weckwerth, Mirko Glinski, Florian Wolschin

Publikováno v: Rapid Communications in Mass Spectrometry. 19:3626-3632

Reversible and differential multisite protein phosphorylation is an important mechanism controlling the activity of cellular proteins. Here we describe a robust and highly selective approach for the identification and relative quantification of site-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffcddcab416f8d42b5e9f61acfbe040
https://doi.org/10.1002/rcm.2236

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Cell-specific protein profiling in Arabidopsis thaliana trichomes: identification of trichome-located proteins involved in sulfur metabolism and detoxification

Autor: Berit Ebert, Wolfram Weckwerth, Ulrike Simon-Rosin, Daniela Zoeller, Joachim Fisahn, Mirko Glinski, Stefanie Wienkoop

Publikováno v: Phytochemistry. 65:1641-1649

Metabolite, protein, and transcript analysis at the cellular level gives unparalleled insight into the complex roles tissues play in the plant system. However, while capillary electrophoresis and PCR amplification strategies make the profiling of met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b239a63996b452f9071a3f3f17dd8a98
https://doi.org/10.1016/j.phytochem.2004.03.026

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Biosynthesis of PF1022A and Related Cyclooctadepsipeptides

Autor: Wolfram Weckwerth, Koichi Miyamoto, Katsuhura Iinuma, Martin Krause, Mirko Glinski, Thomas Storm, Gerd Bonse, Horst Kleinkauf, Rainer Zocher

Publikováno v: Journal of Biological Chemistry. 275:17909-17915

PF1022A belongs to a recently identified class of N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties. Described here is the cell-free synthesis of this CODP and related structures, as well as the purification and enzymati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f663bdfbee9afe69abc5d11619ff8f
https://doi.org/10.1074/jbc.m001084200

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