Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mirko Altenkämper"'
Autor:
Yulin Wang, Mirko Altenkämper, Benjamin Bechem, Johann Perruchon, Hans-Martin Dahse, Martin Schlitzer, Michael Lanzer, Swetlana Heinrich, Regina Ortmann
Publikováno v:
European Journal of Medicinal Chemistry. 46:1331-1342
Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of th
Autor:
Gerhard Klebe, Mirko Altenkämper, Matthias Zentgraf, Michael Eisenmann, Johann Perruchon, Holger Steuber, Martin Schlitzer, Regina Ortmann
Publikováno v:
ChemMedChem. 4:809-819
Diabetes mellitus is a universal health problem. The World Health Organization (WHO) estimates that 150 million people suffer from diabetes mellitus worldwide in 2005. Long-term complications are a serious problem in the treatment of diabetes, manife
Autor:
Jochen Wiesner, Regina Ortmann, Gerhard Klebe, Katrin Silber, Hassan Jomaa, Martin Schlitzer, Johann Perruchon, Mirko Altenkämper
Publikováno v:
ChemMedChem. 3:1232-1241
Fosmidomycin and its homologue FR900098 are inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, which is part of the mevalonate-independent isoprenoid biosynthetic pathway. Replacement of the phosphonate moiety by uncharged sulfone or sulf
Autor:
Martin Schlitzer, Hans-Martin Dahse, Peter W. Haebel, Alexander Hillebrecht, Katrin Silber, Jacek Sakowski, Regina Ortmann, Jochen Wiesner, Katja Kohring, Mirko Altenkämper, Gerhard Klebe, Hassan Jomaa
Publikováno v:
ChemMedChem. 3:1217-1231
The development of farnesyltransferase inhibitors directed against Plasmodium falciparum is a strategy towards new drugs against malaria. Previously, we described benzophenone-based farnesyltransferase inhibitors with high in vitro antimalarial activ
Publikováno v:
Archiv der Pharmazie. 338:9-17
We recently described two novel aryl binding sites of farnesyltransferase. The 4- and 5-arylsubstituted thienylacryloyl moieties turned out as appropriate substituents for our benzophenone-based AAX-peptidomimetic capable for occupying the far aryl b
Publikováno v:
Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6f5886672625509457ffd3eef4dda9
https://doi.org/10.1002/9780470508169.ch34
https://doi.org/10.1002/9780470508169.ch34
Autor:
Mirko Altenkämper, Johann Perruchon, Michael Lanzer, Yulin Wang, Hans-Martin Dahse, Benjamin Bechem, Peter Chiba, Swetlana Heinrich, Regina Ortmann, Jennifer Rath, Andrea Mädel, August Stich, Martin Schlitzer, M. Hitzler, Ellen Freunscht
Publikováno v:
Bioorganicmedicinal chemistry. 17(22)
Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity. The most active compounds display submicromolar activity against Plasmodium falciparum. Micromolar activity is obtained against