Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Mirko Hechenberger"'
1
Scaffold hopping approach towards various AFQ-056 analogs as potent metabotropic glutamate receptor 5 negative allosteric modulators
Autor: Ulrich Abel, Patrick Plitt, Kai-Uwe Klein, Mirko Hechenberger, Udo Meyer, Sander G. A. van Assema, Holger Kubas, Harm W. Spexgoor, Ronalds Zemribo
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:6370-6376
The metabotropic glutamate receptor subtype 5 has evolved into a promising target for the treatment of various diseases of the central nervous system, such as Fragile X and l -DOPA induced dyskinesia. One of the most advanced clinical compound is Nov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6397fe4ac3e1a75ee548e5012845b5
https://doi.org/10.1016/j.bmcl.2013.09.059
Zobrazit plný text záznamu
2
Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on l-DOPA-induced dyskinesia
Autor: Flora Mela, Chris G. Parsons, Andreas Gravius, Małgorzata Pietraszek, Carsten Tober, Wojciech Danysz, Jens Nagel, Andrzej Dekundy, Martine van der Elst, Mirko Hechenberger
Publikováno v: Journal of Neural Transmission. 118:1703-1716
Subtype 5 metabotropic glutamate receptors (mGluR5) are abundant in the basal ganglia, amygdala, septum, hippocampus, peripheral sensory neurones and dorsal horn of the spinal cord. Thus, mGluR5 has been implicated in central processes underlying mov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615c9eedd9a9b9621e8b22c2c2c5051f
https://doi.org/10.1007/s00702-010-0526-0
Zobrazit plný text záznamu
4
KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents
Autor: Christian Kubisch, Thomas J. Jentsch, Mirko Hechenberger, Frank Weinreich, Björn C. Schroeder
Publikováno v: Journal of Biological Chemistry. 275:24089-24095
KCNQ2 and KCNQ3, both of which are mutated in a type of human neonatal epilepsy, form heteromeric potassium channels that are expressed in broad regions of the brain. The associated current may be identical to the M-current, an important regulator of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017ae246d98e8d5c995b3963ae38d20d
https://doi.org/10.1074/jbc.m003245200
Zobrazit plný text záznamu
5
Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators
Autor: Holger Kubas, Ilya Pyatkin, Maksims Vanejevs, Ulrich Abel, Udo Meyer, Mirko Hechenberger, Valerjans Kauss, Raisa Ambartsumova, Alexey I. Polosukhin, Bjoern Krueger, Ronalds Zemribo
Publikováno v: Bioorganicmedicinal chemistry letters. 23(16)
A virtual screening approach using various in silico methodologies led to the discovery of 2-(m-tolylamino)-7,8-dihydroquinazolin-5(6H)-one (1) as a moderately active negative allosteric modulator (NAM) of the metabotropic glutamate receptor subtype
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4568815830ffcb642bbde0d72aa43186
https://pubmed.ncbi.nlm.nih.gov/23856046
Zobrazit plný text záznamu
6
A Family of Putative Chloride Channels from Arabidopsis and Functional Complementation of a Yeast Strain with a CLC Gene Disruption
Autor: Wolf N. Fischer, Blanche Schwappach, Thomas J. Jentsch, Mirko Hechenberger, Klaus Steinmeyer, Wolf B. Frommer
Publikováno v: Journal of Biological Chemistry. 271:33632-33638
We have cloned four novel members of the CLC family of chloride channels from Arabidopsis thaliana. The four plant genes are homologous to a recently isolated chloride channel gene from tobacco (CLC-Nt1; Lurin, C., Geelen, D., Barbier-Brygoo, H., Gue
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7556d4244edd0d9926e7515de1e213fa
https://doi.org/10.1074/jbc.271.52.33632
Zobrazit plný text záznamu
7
MPSA short communications
Autor: Eugene M. Barnes, Patricia A. Calkin, Satoshi Kuroda, Shigemi Norioka, Masanori Mitta, Ikunoshin Kato, Fumio Sakiyama, Heinz Nika, David T. Chow, Daniel Hess, Edward J. Bures, Hamish D. Morrison, Ruedi Aebersold, G. Marius Clore, Angela M. Gronenborn, Bengt Persson, Patrick Argos, Peter James, Andrew C. Cannons, Larry P. Solomonson, Kenneth E. Dombrowski, William E. Moddeman, Stephen E. Wright, Winona C. Barker, David G. George, Subhendra N. Mattagajasingh, Hara P. Misra, Shuan Shian Huang, Jung San Huang, Y. C. Lee, Wolfgang H. Fischer, A. Grey Craig, Philip N. McFadden, Jonathan A. Lind-quist, M. Bartlet-Jones, W. Jeffery, H. F. Hansen, D. J. C. Pappin, Tomas Bergman, Lars Hjelmqvist, Mats Estonius, Hans Jörnvall, Donna S. Dorow, H. Tschesche, V. Knäuper, T. Kleine, P. Reinemer, S. Schnierer, F. Grams, W. Bode, Christopher Southan, Kenneth Fantom, Patric Lavery, J. B. C. Findlay, D. Akrigg, T. K. Attwood, M. J. Beck, A. J. Bleasby, A. C. T. North, D. J. Parry-Smith, D. N. Perkins, A. Aitken, Y. Patel, H. Martin, D. Jones, K. Robinson, J. Madrazo, S. Howell, Tom Yungwirth, Michael Affolter, Lawrence Amankwa, Harold A. Scheraga, Chao -Yuh Yang, Natalia V. Valentinova, Manlan Yang, Zi -Wei Gu, Antonio M. Gotto, Norman J. Dovichi, Karen C. Waldron, Min Chen, Ian Ireland, Akira Omori, Sachiyo Yoshida, Johann Schaller, Stephan Lengweiler, Egon E. Rickli, José Bubis, Julio O. Ortiz, Carolina Möller, Enrique J. Millán, Victoria L. Boyd, MeriLisa Bozzini, Jindong Zhao, Robert J. DeFranco, Pau -Miau Yuan, G. Marc Loudon, Duy Nguyen, Masaharu Kamo, Takao Kawakami, Norifumi Miyatake, Akira Tsugita, Keiji Takamoto, Kazuo Satake, Oliver Bischof, Mirko Hechenberger, Bernd Thiede, Volker Kruft, Brigitte Wittmann-Liebold, Albrecht Otto, Rainer Benndorf, Peter Jungblut, Monika Ühlein, Henning Urlaub, Rita Berhardt, Regine Kraft, Heike Uhlmann, Vita Beckert, Toshifumi Akizawa, Takaaki Ayabe, Motomi Matsukawa, Michiyasu Itoh, Masatoshi Nishi, Hiroshi Sato, Motoharu Seiki, Masanori Yoshioka, Michal Lebl, Viktor Krchňák, Nikolai F. Sepetov, Petr Kočiš, Marcel Pátek, Zuzana Flegelová, Ronald Ferguson, Kit S. Lam, Robert L. Moritz, James Eddes, Hong Ji, Gavin E. Reid, Richard J. Simpson, William Seffens, C. Dale Poulter, Julia M. Dolence, Pamela D. Bond, Kiyoshi Nokihara, Kazuo Ikegaya, Naoki Morita, Takao Ohmura, S. I. Salikhov, N. J. Sagdiev, A. S. Korneev, Behzod Z. Dolimbek, M. Zhouhair Atassi, J. S. Rosenberg, Z. Yun, P. R. Wyde, M. Z. Atassi, Simon J. Gaskell, Kalyan Rao Anumula, David P. Goldenberg, Ettore Appella, Michelle Fiscella, Nicola Zambrano, Stephen J. Ullrich, Kazuyasu Sakaguchi, Hiroshi Sakamoto, Marc S. Lewis, David Lin, W. Edward Mercer, Carl W. Anderson, Marjorie A. Connelly, Hong Zhang, John D. Sipley, Susan P. Lees-Miller, Stephen P. Jackson, Yong-hong Xie, Jun A. Quion, Chao-yuh Yang, W. F. Brandt, H. Alk, R. Bhaskaran, Chin Yu, C. C. Yang, Agnes H. Henschen, Keith Ashman, Matthias Mann, Juan Guevara, Hung Michael Nguyen, Daniel B. Davison, Joel D. Morrisett, Richard N. Perham, Donald A. Marvin, Martyn F. Symmons, Tamsin D. Terry, Z. H. Beg, J. A. Stonik, J. M. Hoeg, H. B. Brewer, Boris M. Gorovits, C. S. Raman, Paul M. Horowtiz
Publikováno v: Journal of Protein Chemistry. 13:431-512
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ef34d6537f2c82a8b9b3644d6d48729
https://doi.org/10.1007/bf01898855
Zobrazit plný text záznamu
8
Virtual screening for selective allosteric mGluR1 antagonists and structure-activity relationship investigations for coumarine derivatives
Autor: Ieva Jaunzeme, Mirko Hechenberger, Tobias Noeske, Gisbert Schneider, Steffen Renner, Dina Trifanova, Chris G. Parsons, Igors Starchenkovs, Aigars Jirgensons, Tanja Weil, Tanja Bauer, Valerjans Kauss
Publikováno v: ChemMedChem. 2(12)
A virtual screening study towards novel noncompetitive antagonists of the metabotropic glutamate receptor 1 (mGluR1) is described. Alignment-free topological pharmacophore descriptors (CATS) were used to encode the screening compounds. All virtual hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b03b7d0e24f65f32338b56830bc10c
https://pubmed.ncbi.nlm.nih.gov/17868161
Zobrazit plný text záznamu
10
Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p
Autor: Sandra M. Stobrawa, Mirko Hechenberger, Thomas J. Jentsch, Klaus Steinmeyer, Blanche Schwappach
Publikováno v: The Journal of biological chemistry. 273(24)
GEF1 encodes the single CLC putative chloride channel in yeast. Its disruption leads to a defect in iron metabolism (Greene, J. R., Brown, N. H., DiDomenico, B. J., Kaplan, J., and Eide, D. (1993) Mol. Gen. Genet. 241, 542–553). Since disruption of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e217a4760681aa6216fb5c5cb8bb9c59
https://pubmed.ncbi.nlm.nih.gov/9614122
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje