Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients

Autor: Julie Helms, Stéphane Kremer, Hamid Merdji, Malika Schenck, François Severac, Raphaël Clere-Jehl, Antoine Studer, Mirjana Radosavljevic, Christine Kummerlen, Alexandra Monnier, Clotilde Boulay, Samira Fafi-Kremer, Vincent Castelain, Mickaël Ohana, Mathieu Anheim, Francis Schneider, Ferhat Meziani

Publikováno v: Critical Care, Vol 24, Iss 1, Pp 1-11 (2020)

Abstract Background Neurotropism of SARS-CoV-2 and its neurological manifestations have now been confirmed. We aimed at describing delirium and neurological symptoms of COVID-19 in ICU patients. Methods We conducted a bicentric cohort study in two Fr

Externí odkaz: https://doaj.org/article/c3b40ded9ce74b01a0041ff44ed7094e

Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort

Autor: Qian Zhang, Paul Bastard, Haiguo Wu, Adrian Gervais, Seiamak Bahram, Sylvain Mayeur, Sharvari Gujja, Anne Thomas, Alexandre Lederle, Julie Helms, Christiane Moog, Xavier Mariette, Alain Viari, Tristan Stemmelen, Christine Carapito, Olivier Hermine, Richard Li, Daniel A. Lidar, Cécile Macquin, Jean Sibilia, Géraldine Laumond, Shweta Kailasan, Leslie Muller, Sabrina Bibi-Triki, Sylvie Schmidt, Aurélie Hirschler, Raony Guimaraes, Michael Simons, Anne Molitor, Francis Schneider, Damien Sanlaville, Thiên-Nga Chamaraux-Tran, Samira Fafi-Kremer, Pierre-Louis Tharaux, Thomas Chittenden, Angélique Pichot, A. Hanauer, Raphael Carapito, Mirjana Radosavljevic, Véronique Rolli, Bernard Goichot, Yvon Ruch, Olivier Collange, Ouria Tahar, Julien Pottecher, Khaldoun Kuteifan, Razieh Mohseninia, Perrine Spinnhirny, Alice Bernard, Bernard Drenou, Jean-Laurent Casanova, Elisa Pin, Jeffrey R. Gulcher, Paul-Michel Mertes, M. Javad Aman, Peter Nilsson, Jose Malagon-Lopez, François Danion, Yves Hansmann, Ferhat Meziani, Maleka Schenck, Nicodème Paul, Annabel Larnicol, Julia Frappier

Publikováno v: Science Translational Medicine
Science Translational Medicine, 2021, pp.1-59. ⟨10.1126/scitranslmed.abj7521⟩
Science Translational Medicine, American Association for the Advancement of Science, 2021, ⟨10.1126/scitranslmed.abj7521⟩

International audience; The etiopathogenesis of critical COVID-19 remains unknown. Indeed given major confounding factors (age and comorbidities), true drivers of this condition have remained elusive. Here, we employ an unprecedented multi-omics anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4c8db00ee20c68bec583014ad8e8e4
https://hal.science/hal-03436053

Coronavirus disease 2019 3 months after hematopoietic stem cell transplant: A pediatric case report

Autor: Samira Fafi-Kremer, Mirjana Radosavljevic, Aurélie Velay, Catherine Paillard, Charlotte Nazon

Publikováno v: Pediatric Blood & Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108e74a273e2705b2651020d20b10504

Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients

Autor: Christine Kummerlen, Julie Helms, Raphaël Clere-Jehl, Vincent Castelain, Alexandra Monnier, François Severac, Malika Schenck, Mickaël Ohana, Samira Fafi-Kremer, Francis Schneider, Mathieu Anheim, Ferhat Meziani, Stéphane Kremer, Antoine Studer, Clotilde Boulay, Hamid Merdji, Mirjana Radosavljevic

Publikováno v: Critical care, 24(1):491
Critical Care
Critical Care, 2020, 24 (1), ⟨10.1186/s13054-020-03200-1⟩
Critical Care, Vol 24, Iss 1, Pp 1-11 (2020)

Background Neurotropism of SARS-CoV-2 and its neurological manifestations have now been confirmed. We aimed at describing delirium and neurological symptoms of COVID-19 in ICU patients. Methods We conducted a bicentric cohort study in two French ICUs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc736ea76d1a1e3cf2a92740f761065c
https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03200-1#Fun

A de novo ADCY5 mutation causes early‐onset autosomal dominant chorea and dystonia

Autor: Philippe Damier, Mirjana Radosavljevic, Raphael Carapito, Ghada Alsaleh, Louise Ott, Marion Le Gentil, Meiggie Untrau, Seiamak Bahram, Bertrand Isidor, Pierre Jochem, Cédric Le Caignec, Albert David, Nicodème Paul

Publikováno v: Movement Disorders. 30:423-427

Importance Apart from Huntington's disease, little is known of the genetics of autosomal dominant chorea associated with dystonia. Here we identify adenylate cyclase 5 (ADCY5) as a likely new causal gene for early-onset chorea and dystonia. Observati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a20c8e9766fb9bb452c6ceb89717dba
https://doi.org/10.1002/mds.26115