Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

Autor: Fleur Schaper, Mirjan M van Timmeren, Arjen Petersen, Gerda Horst, Marc Bijl, Pieter C Limburg, Johanna Westra, Peter Heeringa

Publikováno v: Molecular Medicine, Vol 22, Iss 1, Pp 12-21 (2016)

Abstract High mobility group box 1 (HMGB1) is a nuclear DNA binding protein that acts as an alarmin when secreted. HMGB1 is increased in systemic lupus erythematosus and might represent a potential therapeutic target. We investigated whether treatmen

Externí odkaz: https://doaj.org/article/e7ed838ff5194e5cb636f3232ac5e2f6

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Autor: Ling Ling Chua, Peter Heeringa, Kirill Tsyganov, Mirjan M. van Timmeren, Coen A. Stegeman, Yong Zhong, Joshua D. Ooi, Hugh H. Reid, Jamie Rossjohn, A. Richard Kitching, Jhih-Hang Jiang, Poh Y. Gan, Lani Shochet, Stephen R. Holdsworth, Jessica Ryan, Peter J. Eggenhuizen, Kim M. O’Sullivan, Lars Fugger, Khai Lee Loh, Anton Y. Peleg

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10(1):3392. Nature Publishing Group
Nature Communications
Ooi, J D, Jiang, J-H, Eggenhuizen, P J, Chua, L L, van Timmeren, M, Loh, K L, O'Sullivan, K M, Gan, P Y, Zhong, Y, Tsyganov, K, Shochet, L R, Ryan, J, Stegeman, C A, Fugger, L, Reid, H H, Rossjohn, J, Heeringa, P, Holdsworth, S R, Peleg, A Y & Kitching, A R 2019, ' A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity ', Nature Communications, vol. 10, no. 1, pp. 3392 . https://doi.org/10.1038/s41467-019-11255-0

Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapidly progressive glomerulonephritis. Here, we show that a Staphylococcus aureus peptide, homologous to an immunodominant M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4a62d2d45fd6ad2b22f862b3837244
http://link.springer.com/article/10.1038/s41467-019-11255-0

Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis

Autor: Thomas Mehrling, Gareth Brady, Eóin C O'Brien, Peter Heeringa, Fionnuala B. Hickey, Mark A. Little, Barbara Fazekas, Mirjan M. van Timmeren, Dearbhaile Dooley, Emma Leacy, Charles D. Pusey, Vincent P. O’Reilly, Frederick W.K. Tam

Publikováno v: Kidney International, 94(5), 926-936. ELSEVIER SCIENCE INC

Current therapies for treating antineutrophil cytoplasm autoantibody (ANCA)-associated vasculitis include cyclophosphamide and corticosteroids. Unfortunately, these agents are associated with severe adverse effects, despite inducing remission in most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3aff98541cae064ca9ffb627ce44bd
https://pubmed.ncbi.nlm.nih.gov/30158055

Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

Autor: Pieter C. Limburg, Marc Bijl, Arjen H. Petersen, Johanna Westra, Gerda Horst, Peter Heeringa, Mirjan M. van Timmeren, Fleur Schaper

Publikováno v: Molecular Medicine, Vol 22, Iss 1, Pp 12-21 (2016)
Molecular medicine, 22, 12-21. FEINSTEIN INST MED RES

High mobility group box 1 (HMGB1) is a nuclear DNA binding protein that acts as an alarmin when secreted. HMGB1 is increased in systemic lupus erythematosus and might represent a potential therapeutic target. We investigated whether treatment with an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a568f8f4e68f5b2fc4740b6bb53949
https://europepmc.org/articles/PMC5004709/

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

Autor: Peter W. Mathieson, Min Chen, Ralf R. Muller, Arjen H. Petersen, Betty S. van der Veen, Patrice A. Lee, Grietje Molema, Simon C. Satchell, Moin A. Saleem, Jochen Zwerina, Coen A. Stegeman, Mirjan M. van Timmeren, Peter Heeringa

Publikováno v: Annals of the Rheumatic Diseases, 70(2), 356-365. BMJ PUBLISHING GROUP

Objective To determine whether inhibition of p38 mitogen-activated protein kinase (p38MAPK) reduces the pathogenicity of anti-neutrophil cytoplasmic autoantibodies (ANCAs) in vitro and in vivo.Methods The effects of the p38MAPK-specific inhibitor AR-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fdf706bb05e4af03ab233e52d0eb55
https://doi.org/10.1136/ard.2010.129106