Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mirjam Zimmerman"'
Autor:
Denis G. Knyazev, Roland Kuttner, Ana-Nicoleta Bondar, Mirjam Zimmerman, Christine Siligan, Peter Pohl
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 78 (2020)
The bacterial channel SecYEG efficiently translocates both hydrophobic and hydrophilic proteins across the plasma membrane. Translocating polypeptide chains may dislodge the plug, a half helix that blocks the permeation of small molecules, from its p
Externí odkaz:
https://doaj.org/article/c508f658f103454396df2a6b80f09f53
Autor:
Sebastian Deichsel, Lisa Frankenreiter, Johannes Fechner, Bernd M Gahr, Mirjam Zimmermann, Helena Mastel, Irina Preis, Anette Preiss, Anja C Nagel
Publikováno v:
eLife, Vol 12 (2024)
Notch signalling activity regulates hematopoiesis in Drosophila and vertebrates alike. Parasitoid wasp infestation of Drosophila larvae, however, requires a timely downregulation of Notch activity to allow the formation of encapsulation-active blood
Externí odkaz:
https://doaj.org/article/fdcd8159915742a1a89e5fbf9887bf14
Autor:
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O’Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, ar
Externí odkaz:
https://doaj.org/article/31913551d70443ecbc6be0521f89476a
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Germline stem cell development and differentiation is tightly controlled by the surrounding somatic cells of the stem cell niche. In Drosophila females, cells of the niche emit various signals including Dpp and Wg to balance stem cell renewa
Externí odkaz:
https://doaj.org/article/ae068ff87b3148bca4ff1bff0019aac6
Autor:
Lisa Frankenreiter, Bernd M. Gahr, Hannes Schmid, Mirjam Zimmermann, Sebastian Deichsel, Philipp Hoffmeister, Aleksandra Turkiewicz, Tilman Borggrefe, Franz Oswald, Anja C. Nagel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The highly conserved Notch signaling pathway controls a multitude of developmental processes including hematopoiesis. Here, we provide evidence for a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription f
Externí odkaz:
https://doaj.org/article/1dc96dd13eb84d14a5b10673ca6bc5a5
Publikováno v:
Religions, Vol 13, Iss 2, p 139 (2022)
Nowadays, people show various forms of religious commitment. To better understand this heterogeneity, it is necessary to analyze the factors that predict that commitment. For this purpose, the paper raises the question of whether and how such commitm
Externí odkaz:
https://doaj.org/article/d0ee12d6900044d2951bb5cfb18eb6c5
Publikováno v:
Hereditas, Vol 155, Iss 1, Pp 1-12 (2018)
Abstract Background DNA damage generally results in the activation of ATM/ATR kinases and the downstream checkpoint kinases Chk1/Chk2. In Drosophila melanogaster, the ATR homologue meiotic 41 (mei-41) is pivotal to DNA damage repair and cell cycle ch
Externí odkaz:
https://doaj.org/article/e44b77925e894b168c5295516fd30df0
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1672 (2021)
The Notch signaling pathway is pivotal to cellular differentiation. Activation of this pathway involves proteolysis of the Notch receptor and the release of the biologically active Notch intracellular domain, acting as a transcriptional co-activator
Externí odkaz:
https://doaj.org/article/ff86cd4a37364b038af7dcab4331854b
Autor:
Ilie Sachelaru, Lukas Winter, Denis G. Knyazev, Mirjam Zimmermann, Andreas Vogt, Roland Kuttner, Nicole Ollinger, Christine Siligan, Peter Pohl, Hans-Georg Koch
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The heterotrimeric SecYEG complex cooperates with YidC to facilitate membrane protein insertion by an unknown mechanism. Here we show that YidC contacts the interior of the SecY channel resulting in a ligand-activated and voltage-dependent c
Externí odkaz:
https://doaj.org/article/4a079782df9745798e53ae586a20f9e7
Autor:
Heiko Praxenthaler, Anja C Nagel, Adriana Schulz, Mirjam Zimmermann, Markus Meier, Hannes Schmid, Anette Preiss, Dieter Maier
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006774 (2017)
Cell fate choices during metazoan development are driven by the highly conserved Notch signalling pathway. Notch receptor activation results in release of the Notch intracellular domain (NICD) that acts as transcriptional co-activator of the DNA-bind
Externí odkaz:
https://doaj.org/article/40ddec43b486410eadf0c3ddf0121cd4