Výsledky vyhledávání - "Mirjam W.M. van den Bosch"

LPS Induces the Degradation of Programmed Cell Death Protein 4 (PDCD4) to Release Twist2, Activating c-Maf Transcription to Promote Interleukin-10 Production

Autor: Derek S. Johnson, Mirjam W.M. van den Bosch, Eva M. Palsson-McDermott, Luke A. J. O'Neill

Publikováno v: Journal of Biological Chemistry. 289:22980-22990

Programmed cell death protein 4 (PDCD4) is a tumor suppressor and has also been shown to suppress production of the immunomodulatory cytokine IL-10. The precise role of PDCD4 in IL-10 induction in macrophages is still not fully understood. Incubation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444654caee326519ba7b5b6b22a4f4e1
https://doi.org/10.1074/jbc.m114.573089

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Pyruvate Kinase M2 regulates Hif-1α activity and IL-1β induction, and is a critical determinant of the Warburg Effect in LPS-activated macrophages

Autor: Luke A. J. O'Neill, Clary B. Clish, Mario A.R. Lauterbach, Susan R. Quinn, Frederick J. Sheedy, Anne M. Curtis, Daniel G.W. Johnston, Joseph Keane, Gautam Goel, Craig J. Thomas, Raquel Domingo-Fernandez, William J. Israelsen, Matthew G. Vander Heiden, Eva M. Palsson-McDermott, Mirjam W.M. van den Bosch, Laura E. Gleeson, Ramnik J. Xavier, Jian-kang Jiang

SummaryMacrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a098b127ed46129ab7464d688c98fbc0
https://europepmc.org/articles/PMC5198835/

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