Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mirjam S. de Pagter"'
Autor:
Sean W. Willemse, Kit C. B. Roes, Philip Van Damme, Orla Hardiman, Caroline Ingre, Monica Povedano, Naomi R. Wray, Marleen Gijzen, Mirjam S. de Pagter, Koen C. Demaegd, Annemarie F. C. Janse, Roel G. Vink, Boudewijn T. H. M. Sleutjes, Adriano Chiò, Philippe Corcia, Evy Reviers, Ammar Al-Chalabi, Matthew C. Kiernan, Leonard H. van den Berg, Michael A. van Es, Ruben P. A. van Eijk
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Given the large genetic heterogeneity in amyotrophic lateral sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis identified that patients homozygous for the
Externí odkaz:
https://doaj.org/article/30fbd5e916074b949d8c09f8b72ea468
Autor:
Verena Passerini, Efrat Ozeri-Galai, Mirjam S. de Pagter, Neysan Donnelly, Sarah Schmalbrock, Wigard P. Kloosterman, Batsheva Kerem, Zuzana Storchová
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.
Externí odkaz:
https://doaj.org/article/e73b828e409d4bfbb86d27e03daef072
Autor:
Maja Kneissig, Kristina Keuper, Mirjam S de Pagter, Markus J van Roosmalen, Jana Martin, Hannah Otto, Verena Passerini, Aline Campos Sparr, Ivo Renkens, Fenna Kropveld, Anand Vasudevan, Jason M Sheltzer, Wigard P Kloosterman, Zuzana Storchova
Publikováno v:
eLife, Vol 8 (2019)
Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years. We sho
Externí odkaz:
https://doaj.org/article/574814c022834ba19e0b5bb4d7e9d020
Autor:
Maja Kneissig, Kristina Keuper, Mirjam S de Pagter, Markus J van Roosmalen, Jana Martin, Hannah Otto, Verena Passerini, Aline Campos Sparr, Ivo Renkens, Fenna Kropveld, Anand Vasudevan, Jason M Sheltzer, Wigard P Kloosterman, Zuzana Storchova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74da123648215b60af598ae10dce7cdc
https://doi.org/10.7554/elife.50292.sa2
https://doi.org/10.7554/elife.50292.sa2
Autor:
Markus J. van Roosmalen, Fenna Kropveld, Anand Vasudevan, Zuzana Storchova, Jana Martin, Wigard P. Kloosterman, Ivo Renkens, Jason M. Sheltzer, Aline Campos Sparr, Hannah Otto, Maja Kneissig, Verena Passerini, Kristina Keuper, Mirjam S. de Pagter
Publikováno v:
eLife, Vol 8 (2019)
eLife
ELIFE
eLife, 8. eLife Sciences Publications
eLife
ELIFE
eLife, 8. eLife Sciences Publications
© 2019, Kneissig et al. Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d83415b9ee2d488b62590f2247bebdd
https://elifesciences.org/articles/50292
https://elifesciences.org/articles/50292
Autor:
Giuliana K Moeller, Anastasia Yurievna Kuznetsova, Jeroen A.D.M. de Roos, Zuzana Storchova, Wigard P. Kloosterman, Guido J.R. Zaman, Mirjam S. de Pagter, Christian Kuffer, Stefan C. Müller, Milena Dürrbaum, Katarzyna Seget
Publikováno v:
Cell Cycle. 14:2810-2820
Up to 80% of human cancers, in particular solid tumors, contain cells with abnormal chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal instability. Whereas in some tumors the aneuploidy occurs by missegregation of one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee659f06caee48d85c5ac65cb855088
https://doi.org/10.1080/15384101.2015.1068482
https://doi.org/10.1080/15384101.2015.1068482
Autor:
Titia Sijen, Geeta Ramdayal, Manfred Kayser, Alexander Lindenbergh, Dmitry Zubakov, Mijke Visser, Mirjam S. de Pagter
Publikováno v:
Forensic Science International: Genetics, 6(5), 565-577. Elsevier Ireland Ltd
In current forensic practice, information about the possible biological origin of forensic traces is mostly determined using protein-based presumptive testing. Recently, messenger RNA-profiling has emerged as an alternative strategy to examine the bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381f5fae89fa9afc54a352085c2eebbf
https://doi.org/10.1016/j.fsigen.2012.01.009
https://doi.org/10.1016/j.fsigen.2012.01.009
Publikováno v:
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 200
In recent years, enormous progress has been made with respect to the identification of somatic mutations that contribute to cancer development. Mutation types range from small substitutions to large structural genomic rearrangements, including comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::949c0eabfd2a2239c5854a92bab4a0d0
https://pubmed.ncbi.nlm.nih.gov/26376877
https://pubmed.ncbi.nlm.nih.gov/26376877
Autor:
Markus J. van Roosmalen, Annette F. Baas, Karen Duran, Ellen van Binsbergen, Ron Hochstenbach, Masoumeh Tavakoli-Yaraki, Wigard P. Kloosterman, Mirjam S. de Pagter, Edwin Cuppen, Lars T. van der Veken, Ivo Renkens
Publikováno v:
American Journal of Human Genetics, 96(4), 651-6. Cell Press
American Journal of Human Genetics, 96(4), 651. Cell Press
American Journal of Human Genetics, 96(4), 651. Cell Press
Chromothripsis represents an extreme class of complex chromosome rearrangements ( CCRs) with major effects on chromosomal architecture. Although recent studies have associated chromothripsis with congenital abnormalities, the incidence and pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc1139c9877b9cb7164ab38b5f029f8
https://pure.knaw.nl/portal/en/publications/a0b39112-93c2-43fa-a74a-daaea7f70480
https://pure.knaw.nl/portal/en/publications/a0b39112-93c2-43fa-a74a-daaea7f70480
Autor:
Karen Duran, Martijn P. Lolkema, Wigard P. Kloosterman, Marlous Hoogstraat, Emile E. Voest, Geert A. Cirkel, Clarence Lee, Mirjam S. de Pagter, Trudy N. Jonges, Petronella O. Witteveen, Edwin Cuppen, Tanisha Guy, Marco J. Koudijs, Ivo Renkens, Timothy T. Harkins, Markus J. van Roosmalen, Ruben van 't Slot, Isaac J. Nijman, Ronald P. Zweemer, Jennifer Kreeftmeijer
Publikováno v:
Genome Research, 24(2), 200-11. Cold Spring Harbor Laboratory Press
Intra-tumor heterogeneity is a hallmark of many cancers and may lead to therapy resistance or interfere with personalized treatment strategies. Here, we combined topographic mapping of somatic breakpoints and transcriptional profiling to probe intra-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd95882636dc1079ee5416b03e47e6c
https://doi.org/10.1101/gr.161026.113
https://doi.org/10.1101/gr.161026.113