Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease.

Autor: Magda L Atilano, Alexander Hull, Catalina-Andreea Romila, Mirjam L Adams, Jacob Wildfire, Enric Ureña, Miranda Dyson, Jorge Ivan-Castillo-Quan, Linda Partridge, Kerri J Kinghorn

Publikováno v: PLoS Genetics, Vol 19, Iss 12, p e1011063 (2023)

Mutations in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD) and are the greatest known genetic risk factors for Parkinson's disease (PD). Communication between the gut and brain and immune dysregulation are increasingly being

Externí odkaz: https://doaj.org/article/ac15018b4078410a9ca7e92d2fad388d

Sex-Dependent Modulation of Acute Stress Reactivity After Early Life Stress in Mice: Relevance of Mineralocorticoid Receptor Expression

Autor: Lisa T C M van Weert, Ruth Damsteegt, Mirjam L Adams, Marian Joëls, R.A. Sarabdjitsingh, Onno C. Meijer, Valeria Bonapersona

Publikováno v: Frontiers in Behavioral Neuroscience, 13. FRONTIERS MEDIA SA
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Frontiers in Behavioral Neuroscience, 13:181. Frontiers Media S.A.

Early life stress (ELS) is considered a major risk factor for developing psychopathology. Increasing evidence points towards sex-dependent dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis as a contributing mechanism. Additionally, clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093faf84204ca7a224053fc3a294ff36
https://hdl.handle.net/1887/3195251