Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

Autor: Martijn G. S. Rutten, Yu Lei, Joanne H. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore A. Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel E. Thomas, Justina C. Wolters, Hilda van den Bos, Gilles Mithieux, Fabienne Rajas, Adil Mardinoglu, Diana C. J. Spierings, Alain de Bruin, Bart van de Sluis, Maaike H. Oosterveer

Publikováno v: Cancer & Metabolism, Vol 11, Iss 1, Pp 1-11 (2023)

Abstract Background Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is

Externí odkaz: https://doaj.org/article/176971327ab64839a0921d89e984a866

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Autor: Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Benedek Halmos, Deepti Dabral, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, Marit Westerterp

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)

Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype o

Externí odkaz: https://doaj.org/article/cce4b1448a8b440488b90cdc27f0a71a

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

Autor: Klaske M. Schukken, Yinan Zhu, Petra L. Bakker, Mirjam H. Koster, Liesbeth Harkema, Sameh A. Youssef, Alain de Bruin, Floris Foijer

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract Chromosomal instability (CIN) is a hallmark of cancer, leading to aneuploid cells. To study the role that CIN plays in tumor evolution, several mouse models have been engineered over the last 2 decades. These models have unequivocally shown

Externí odkaz: https://doaj.org/article/2ee0cafcaa344471b97c2a117ffcebdc

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet.

Autor: Onne A H O Ronda, Bert J M van de Heijning, Alain de Bruin, Rachel E Thomas, Ingrid Martini, Martijn Koehorst, Albert Gerding, Mirjam H Koster, Vincent W Bloks, Angelika Jurdzinski, Niels L Mulder, Rick Havinga, Eline M van der Beek, Dirk-Jan Reijngoud, Folkert Kuipers, Henkjan J Verkade

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0232069 (2020)

Mouse models are frequently used to study mechanisms of human diseases. Recently, we observed a spontaneous bimodal variation in liver weight in C57BL/6JOlaHsd mice fed a semisynthetic diet. We now characterized the spontaneous variation in liver wei

Externí odkaz: https://doaj.org/article/7a34a45721614e4783dbcd572ecf0fb3

Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model

Autor: Angela J. C. Tol, Kaja Hribar, Janine Kruit, Laura Bongiovanni, Marcel A. Vieira‐Lara, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Martijn Koehorst, Alain de Bruin, Barbara M. Bakker, Maaike H. Oosterveer, Eline M. van der Beek

Publikováno v: Journal of Physiology, 601(10), 1761-1780. Wiley-Blackwell
Journal of Physiology, 601(10), 1761-1780. BLACKWELL PUBLISHING
Tol, A J C, Hribar, K, Kruit, J, Bongiovanni, L, Vieira-Lara, M A, Koster, M H, Kloosterhuis, N J, Havinga, R, Koehorst, M, de Bruin, A, Bakker, B M, Oosterveer, M H & van der Beek, E M 2023, ' Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model ', Journal of Physiology, vol. 601, no. 10, pp. 1761-1780 . https://doi.org/10.1113/JP284061

Hyperglycaemia in pregnancy (HIP) is a pregnancy complication characterized by mild to moderate hyperglycaemia that negatively impacts short- and long-term health of mother and child. However, relationships between severity and timing of pregnancy hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1ee18648d2bd9e7fcfb867525e4768
https://dspace.library.uu.nl/handle/1874/429424