Výsledky vyhledávání - "Mirjam A M Lohuis"

Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet

Autor: Fan Liu, Mirjam A M Lohuis, Rima H. Mistry, Uwe J. F. Tietge, Henkjan J. Verkade, Hauke Smidt, Klaudyna Borewicz

Publikováno v: Molecular Nutrition and Food Research 64 (2020) 12
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research, 64(12):1900922. Wiley
Molecular Nutrition and Food Research, 64(12)

Scope The gut microbiota might critically modify metabolic disease development. Dietary fibers such as galacto‐oligosaccharides (GOS) presumably stimulate bacteria beneficial for metabolic health. This study assesses the impact of GOS on obesity, g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a90e4879e2ec4e13a94a7ff33ad7d8e

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Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-induced hypercholesterolaemia

Autor: Vincent W. Bloks, Uwe J. F. Tietge, Lidiya G. Dimova, Mirjam A M Lohuis, Henkjan J. Verkade

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports, 8:8824. Nature Publishing Group

Breast milk cholesterol content may imply to affect short- and long-term cholesterol homeostasis in the offspring. However, mechanisms of regulating milk cholesterol concentration are only partly understood. We used different mouse models to assess t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bb3e4d7fe46b5cf18fae2edcceac4d
http://link.springer.com/article/10.1038/s41598-018-27115-8

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Absence of Intestinal Microbiota during Gestation and Lactation Does Not Alter the Metabolic Response to a Western-type Diet in Adulthood

Autor: Henkjan J. Verkade, Mirjam A M Lohuis, Hermie J. M. Harmsen, Cornelieke C N Werkman, Uwe J. F. Tietge

Publikováno v: Molecular Nutrition & Food Research, 63(3):e1800809. Wiley

Scope Microbiota composition in early life is implied to affect the risk to develop obesity in adulthood. It is unclear whether this risk is due to long-lasting microbiome-induced changes in host metabolism. This study aims to identify whether the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e913f5946f8894e3e9170df3b8069ea
https://doi.org/10.1002/mnfr.201800809

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A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

Autor: Michael T. McManus, Jonathan S. Weissman, Cornelia M Voorburg, Weronika Patena, Robert Jan Lebbink, Emily M LeProust, Maaike E. Ressing, Michael L. van de Weijer, Rutger D. Luteijn, Emmanuel J. H. J. Wiertz, Hanneke Hoelen, Siyuan Chen, Elisabeth Kremmer, Rob C. Hoeben, Mirjam A M Lohuis, Michael C. Bassik

Publikováno v: Nature Communications, 5
Nat. Commun. 5:3832 (2014)
Nature Communications

Misfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human cytomegalovirus protein US11 exploits this ER-associated protein degradation (ERAD) pathway to downregulate HLA class I mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf770428675839ba7972043ccf005a4
http://hdl.handle.net/1887/104865

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