Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Mirita Franz‐Wachtel"'
Autor:
Yannick Frey, Cristiana Lungu, Florian Meyer, Franziskus Hauth, Daniel Hahn, Corinna Kersten, Vivien Heller, Mirita Franz-Wachtel, Boris Macek, Igor Barsukov, Monilola A. Olayioye
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110203- (2024)
Summary: Deleted in liver cancer 3 (DLC3) is a Rho GTPase-activating protein (RhoGAP) that plays a crucial role in maintaining adherens junction integrity and coordinating polarized vesicle transport by modulating Rho activity at the plasma membrane
Externí odkaz:
https://doaj.org/article/c2dd2d7e607b4fcbab13d79d9dba9f93
Autor:
Alina Hoffmann, Ursula Steffens, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Anisja Harbig, Kirstin Scherlach, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by Streptomyces tendae HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a spaghetti-like phenotype i
Externí odkaz:
https://doaj.org/article/4833b7c76779426b9186573341897b4a
Autor:
Katharina Sporbeck, Maximilian L. Haas, Carmen J. Pastor-Maldonado, David S. Schüssele, Catherine Hunter, Zsuzsanna Takacs, Ana L. Diogo de Oliveira, Mirita Franz-Wachtel, Chara Charsou, Simon G. Pfisterer, Andrea Gubas, Patricia K. Haller, Roland L. Knorr, Manuel Kaulich, Boris Macek, Eeva-Liisa Eskelinen, Anne Simonsen, Tassula Proikas-Cezanne
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-23 (2023)
Abstract Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the formation of autophagosomes. WIPI1, instead, assists WIPI2 in efficiently recruiting the ATG
Externí odkaz:
https://doaj.org/article/d0288956339a424480d31074800a3152
Autor:
Michael S. Werner, Tobias Loschko, Thomas King, Shelley Reich, Tobias Theska, Mirita Franz-Wachtel, Boris Macek, Ralf J. Sommer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant develo
Externí odkaz:
https://doaj.org/article/0de7d5d168d5427c97c436b3d3f34b0f
Autor:
Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold V. Distel, Daniel Zips, Mahmoud Toulany
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-21 (2022)
Abstract Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is limited in many patie
Externí odkaz:
https://doaj.org/article/630603e5d2b0463f9d0e1dedf5c54654
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progressi
Externí odkaz:
https://doaj.org/article/3a3ecf4d58c141179747416b4b4891cc
Autor:
Sophia Krauss, Theresa A. Harbig, Johanna Rapp, Timm Schaefle, Mirita Franz-Wachtel, Leonie Reetz, Ahmed M. A. Elsherbini, Boris Macek, Stephanie Grond, Hannes Link, Kay Nieselt, Bernhard Krismer, Andreas Peschel, Simon Heilbronner
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous divers
Externí odkaz:
https://doaj.org/article/fb2900638a02438e90f389423ed3b167
Autor:
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Dröge, Christiane Szekat, Peter Sass, Imran T. Malik, Jan Bornikoel, Laura Reinke, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Brötz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-re
Externí odkaz:
https://doaj.org/article/0db489a7ff654f7297e365749f7a453f
Autor:
Alexis Lebecq, Mehdi Doumane, Aurelie Fangain, Vincent Bayle, Jia Xuan Leong, Frédérique Rozier, Maria del Marques-Bueno, Laia Armengot, Romain Boisseau, Mathilde Laetitia Simon, Mirita Franz-Wachtel, Boris Macek, Suayib Üstün, Yvon Jaillais, Marie-Cécile Caillaud
Publikováno v:
eLife, Vol 11 (2022)
Membrane lipids, and especially phosphoinositides, are differentially enriched within the eukaryotic endomembrane system. This generates a landmark code by modulating the properties of each membrane. Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]
Externí odkaz:
https://doaj.org/article/61ef6e6f49164366bd574537a710404c
Autor:
Layla Drwesh, Benjamin Heim, Max Graf, Linda Kehr, Lea Hansen-Palmus, Mirita Franz-Wachtel, Boris Macek, Hubert Kalbacher, Johannes Buchner, Doron Rapaport
Publikováno v:
eLife, Vol 11 (2022)
Signal-anchored (SA) proteins are anchored into the mitochondrial outer membrane (OM) via a single transmembrane segment at their N-terminus while the bulk of the proteins is facing the cytosol. These proteins are encoded by nuclear DNA, translated o
Externí odkaz:
https://doaj.org/article/7dbf58e4eeb745418de493b904849420