Tandem chalcone-sulfonamide hybridization, cyclization and further Claisen–Schmidt condensation: Tuning molecular diversity through reaction time and order and catalyst

Autor: Andrea F. Moura, Felipe T. Martins, Manoel Odorico de Moraes, Aline Bernardes, Cameron Capeletti da Silva, Caridad N. Perez, Mirian R. C. de Castro, Raquel Ferreira Naves

Publikováno v: Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 1345-1354 (2020)

We here report the synthesis of novel chalcone-sulfonamide compounds based on the hybridization at 2′ position and nitro substitution at the side chalcone phenyl ring followed by tandem cyclization into quinolinone derivatives and then a further al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d6ff84b74fb0d7e4334377df781da1
http://www.sciencedirect.com/science/article/pii/S1878535217302137

Novel sulfonamide-chalcone hybrid stimulates inflammation, angiogenesis and upregulates vascular endothelial growth factor (VEGF) in vivo

Autor: Luana Santos Silva, Abel Vieira de Melo Bisneto, Amanda Silva Fernandes, Clever Gomes Cardoso, Carolina Ribeiro e Silva, Cristiene Costa Carneiro, Raquel Ferreira Naves, Jefferson Hollanda Véras, Lee Chen-Chen, Caridad N. Perez, Mirian R. C. de Castro

Publikováno v: Microvascular research. 139

Chalcones and sulfonamides are well-known chemical groups associated with several biological activities such as antibiotic, anti-inflammatory, and antitumor activities. Over the past few decades, a series of sulfonamide-chalcone hybrids have been syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4184170ad145b43222f65a97231c68c4
https://pubmed.ncbi.nlm.nih.gov/34520773

Structural insights into a novel anticancer sulfonamide chalcone

Autor: Manoel Odorico de Moraes Filho, Lidiane J. Michelini, Hamilton B. Napolitano, Caridad N. Perez, Pedro Cravo, Bruno J. Neves, Wesley F. Vaz, Mirian R. C. de Castro, Jean M. F. Custodio, Francisco Stefânio Barreto

Publikováno v: New Journal of Chemistry. 42:3426-3434

Natural products have stood out due to their wide range of biological activities. Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. Although many pharmacological activities of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81a91edc7612773b8068f2c6ccdf7d0d
https://doi.org/10.1039/c7nj03523c

Conformational Variability in Sulfonamide Chalcone Hybrids: Crystal Structure and Cytotoxicity

Autor: Luiz Henrique Keng Queiroz Júnior, Felipe T. Martins, Mirian R. C. de Castro, Ângelo Q. Aragão, Stefânio Barreto, Manoel Odorico de Moraes, Darlene P. K. Queiroz, Caridad N. Perez, Cameron Capeletti da Silva

Publikováno v: Journal of the Brazilian Chemical Society v.27 n.5 2016
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 27, Issue: 5, Pages: 884-898, Published: MAY 2016
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC

Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. They were synthesized by Claisen-Schmidt condensation reaction between N -(4-acetylphenyl)benzenesulfonamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2eb074b1fd1a653ca0a61273d6c7f76
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000500884