Fasciola hepatica extract suppresses fibroblast-like synoviocytes in vitro and alleviates experimental arthritis

Autor: Suelen Pizzolatto Dalmolin, Renata Ternus Pedó, Thales Hein da Rosa, Jordana Miranda de Souza Silva, Mirian Farinon, Maria Luísa Gasparini, Eduardo Cremonese Filippi Chiela, Ana Helena Paz, Martín Pablo Cancela Sehabiague, Henrique Bunselmeyer Ferreira, Rafaela Cavalheiro do Espírito Santo, Fabiany da Costa Gonçalves, Ricardo Machado Xavier

Publikováno v: Advances in Rheumatology, Vol 62, Iss 1, Pp 1-13 (2022)

Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation, fibroblast-like synoviocytes (FLS) activation and joint destruction. Fasciola hepatica is a platyhelminth that releases excretory-

Externí odkaz: https://doaj.org/article/b057801e12464722a005c3799409b6d2

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

Autor: Patricia Gnieslaw de Oliveira, Mirian Farinon, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like syn

Externí odkaz: https://doaj.org/article/a13c24b313094ad19482989ca3d35619

Practical screening tools for sarcopenia in patients with systemic sclerosis

Autor: Marianne Schrader de Oliveira, Markus Bredemeier, Vanessa Hax, Nicole Pamplona Bueno de Andrade, Andrese Aline Gasparin, Rafaela Cavalheiro do Espírito Santo, Guilherme Leví Tres, Mirian Farinon, Leonardo Peterson dos Santos, Ricardo Machado Xavier, Rafael Mendonça da Silva Chakr

Publikováno v: PLoS ONE
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
PLoS ONE, Vol 16, Iss 1, p e0245683 (2021)

Introduction In view of the method of diagnosing sarcopenia being complex and considered to be difficult to introduce into routine practice, the European Working Group on Sarcopenia in Older People (EWGSOP) recommends the use of the SARC-F questionna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8059a946390dc573fd0117fc06384bcb
http://europepmc.org/articles/PMC7822499

Gastrin-releasing peptide and its receptor increase arthritis fibroblast-like synoviocytes invasiveness through activating the PI3K/AKT pathway

Autor: Pércio S. Gulko, Mirian Farinon, Patricia Gnieslaw de Oliveira, Vanessa Schuck Clarimundo, Vivian de Oliveira Nunes Teixeira, Carolina Nor, Ricardo Machado Xavier, Renata Ternus Pedó

Publikováno v: Peptides. 95:57-61

Rheumatoid arthritis (RA) is an autoimmune disease that leads to joint destruction. The fibroblast-like synoviocytes (FLS) has a central role on the disease pathophysiology. The present study aimed to examine the role of gastrin-releasing peptide (GR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd1956241d46dccc549cc3967ce9bc7
https://doi.org/10.1016/j.peptides.2017.07.008

DIFFERENT RESPONSES OF FIBROBLAST-LIKE SYNOVIOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS AND FROM MICE WITH COLLAGEN-INDUCED ARTHRITIS TO INFLAMMATORY STIMULI

Autor: Ricardo Machado Xavier, Adriana Maria Kakehasi, Mirian Farinon, Gustavo Gomes Resende, Tamiris Paula Silva, Suelen Pizzolatto Dalmolin, Marcus V. Andrade, Camilla Ribeiro Lima Machado

Publikováno v: Blucher Medical Proceedings.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27b90b2b72ff00d6a36fe16ca6817584
https://doi.org/10.5151/sbr2019-399