Výsledky vyhledávání - "Mirian Claudia de Souza, Pereira"

Akademický článek

Synthesis and Anti-Trypanosoma cruzi Activity of New Pyrazole-Thiadiazole Scaffolds

Autor: Thamyris Perez de Souza, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Vitoria Barbosa Paes, Lucas Penha Dutra, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira

Publikováno v: Molecules, Vol 29, Iss 15, p 3544 (2024)

Chagas disease, a silent but widespread disease that mainly affects a socioeconomically vulnerable population, lacks innovative safe drug therapy. The available drugs, benznidazole and nifurtimox, are more than fifty years old, have limited efficacy,

Externí odkaz: https://doaj.org/article/404ec5fb989244f89628f9043b63ee64

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Akademický článek

Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models

Autor: Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Guilherme Curty Lechuga, Giseli Capaci Rodrigues, Omar Ginoble Pandoli, Druval Santos de Sá, Mirian Claudia de Souza Pereira

Publikováno v: Biology, Vol 12, Iss 9, p 1222 (2023)

Chagas disease therapy still relies on two nitroderivatives, nifurtimox and benznidazole (Bz), which have important limitations and serious adverse effects. New therapeutic alternatives for this silent disease, which has become a worldwide public hea

Externí odkaz: https://doaj.org/article/1f983e5646b441299b7b5c4305f3522d

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Akademický článek

In the Acute Phase of Trypanosoma cruzi Infection, Liver Lymphoid and Myeloid Cells Display an Ambiguous Phenotype Combining Pro- and Anti-Inflammatory Markers

Autor: Carina de Lima Pereira dos Santos, Natalia Vacani-Martins, Cynthia Machado Cascabulho, Mirian Claudia de Souza Pereira, Ian Nicholas Crispe, Andrea Henriques-Pons

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Multiple cell populations, cellular biochemical pathways, and the autonomic nervous system contribute to maintaining the immunological tolerance in the liver. This tolerance is coherent because the organ is exposed to high levels of bacterial pathoge

Externí odkaz: https://doaj.org/article/ca27463cf3a54e5894765a2fb6db9049

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Synthesis by Microwave Irradiation, Molecular Structural Analysis and Trypanocidal Activity of Novel Pyrazole-tetrahydropyrimidine Derivatives

Autor: Maurício Silva dos Santos, Cynthia Nathalia Pereira, Júlia Akihoshi de Oliveira, Leonardo da Silva Lara, Lorraine Martins Rocha Orlando, Mirian Claudia de Souza Pereira

Publikováno v: Current Organic Synthesis. 20:707-715

Background: A series of new eight 2-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1,4,5,6-tetrahydropyrimidines 1(a-h) were synthesized by microwave irradiation technique. In vitro phenotypic screening was performed to evaluate the effect of these compounds on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a2e759933d61f03bd1dec0dac56a0b0
https://doi.org/10.2174/1570179420666230110161122

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Akademický článek

Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against Trypanosoma cruzi: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Autor: Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araújo Souto, Maurício Silva dos Santos, Mirian Claudia de Souza Pereira

Publikováno v: Pharmaceutics, Vol 14, Iss 5, p 995 (2022)

Chagas disease, a century-old disease that mainly affects the impoverished population in Latin America, causes high morbidity and mortality in endemic countries. The available drugs, benznidazole (Bz) and nifurtimox, have limited effectiveness and in

Externí odkaz: https://doaj.org/article/9e3904bc717a4009ae4d12ad916c1875

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Akademický článek

Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins

Autor: Laura Lacerda Coelho, Isabela Resende Pereira, Mirian Claudia de Souza Pereira, Liliane Mesquita, Joseli Lannes-Vieira, Daniel Adesse, Luciana Ribeiro Garzoni

Publikováno v: Parasites & Vectors, Vol 11, Iss 1, Pp 1-11 (2018)

Abstract Background Cardiac fibrosis is a consequence of chronic chagasic cardiomyopathy (CCC). In other cardiovascular diseases, the protagonist role of fibroblasts in cardiac fibrosis is well established. However, the role of cardiac fibroblasts (C

Externí odkaz: https://doaj.org/article/44c17687381d487bb41e65c953992ea3

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Akademický článek

Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi

Autor: Guilherme Curty Lechuga, Júlio Cesar Borges, Claudia Magalhães Calvet, Humberto Pinheiro de Araújo, Aline Araujo Zuma, Samara Braga do Nascimento, Maria Cristina Machado Motta, Alice Maria Rolim Bernardino, Mirian Claudia de Souza Pereira, Saulo Cabral Bourguignon

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 154-164 (2016)

Chagas disease is a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. The current drugs used to treat this disease have limited efficacy and produce severe side effects. Quinolines, nitrogen heterocycle compounds that

Externí odkaz: https://doaj.org/article/4a2648c0a17b48edabc8f84da8374811

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Akademický článek

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.

Autor: Claudia Magalhaes Calvet, Jun Yong Choi, Diane Thomas, Brian Suzuki, Ken Hirata, Sharon Lostracco-Johnson, Liliane Batista de Mesquita, Alanderson Nogueira, Marcelo Meuser-Batista, Tatiana Araujo Silva, Jair Lage Siqueira-Neto, William R Roush, Mirian Claudia de Souza Pereira, James H McKerrow, Larissa M Podust

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006132 (2017)

Chagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variable efficacy

Externí odkaz: https://doaj.org/article/d28ce6dcdb8a492fbc90c6bb0086a39f

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Role of FAK signaling in chagasic cardiac hypertrophy

Autor: Liliane Batista de Mesquita, Gabriel Melo de Oliveira, Mirian Claudia de Souza Pereira, Amanda R. Tucci, Guilherme C. Lechuga, Priscila Silva Grijó Farani, Otacilio C. Moreira, Constança Britto, Ana Carolina Eleuterio, Francisco Odêncio Rodrigues de Oliveira

Publikováno v: Brazilian Journal of Infectious Diseases, Vol 24, Iss 5, Pp 386-397 (2020)
Brazilian Journal of Infectious Diseases v.24 n.5 2020
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Volume: 24, Issue: 5, Pages: 386-397, Published: 30 NOV 2020

Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ab0507aebede66cbfcac3c7ed71d41
http://www.sciencedirect.com/science/article/pii/S1413867020301227

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