Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke

Autor: Fatemeh Ranjbar Taklimie, Natalie Gasterich, Miriam Scheld, Ralf Weiskirchen, Cordian Beyer, Tim Clarner, Adib Zendedel

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 6, p 1271 (2019)

Ischemic stroke causes rapid hypoxic damage to the core neural tissue which is followed by graded chronological tissue degeneration in the peri-infarct zone. The latter process is mainly triggered by neuroinflammation, activation of inflammasomes, pr

Externí odkaz: https://doaj.org/article/4a8ba3f72f844a63b8256ef31ce757b7

Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain

Autor: Cordian Beyer, Sudip Bhattarai, Bernd Denecke, Stella Nyamoya, Tanja Hochstrasser, Miriam Scheld, Felix Schweiger, Markus Kipp, Anja Horn-Bochtler, Christoph Schmitz, Petra Fallier-Becker, Sven Olaf Rohr, Uta Chrzanowski, Tim Clarner, Sandra Amor

Publikováno v: Neurochemistry International, 126, 139-153. Elsevier Limited
Chrzanowski, U, Bhattarai, S, Scheld, M, Clarner, T, Fallier-Becker, P, Beyer, C, Rohr, S O, Schmitz, C, Hochstrasser, T, Schweiger, F, Amor, S, Horn-Bochtler, A, Denecke, B, Nyamoya, S & Kipp, M 2019, ' Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain ', Neurochemistry International, vol. 126, pp. 139-153 . https://doi.org/10.1016/j.neuint.2019.03.005

Brain-intrinsic degenerative cascades are a proposed factor driving inflammatory lesion formation in multiple sclerosis (MS) patients. We recently showed that encephalitogenic lymphocytes are recruited to the sites of active demyelination induced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7302ec4751a41ed3cf6189556f09671c
https://doi.org/10.1016/j.neuint.2019.03.005

Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial Functions

Autor: Cordian Beyer, Stella Nyamoya, Nico Teske, Adib Zendedel, Annette Liessem-Schmitz, Tim Clarner, Miriam Scheld, Athanassios Fragoulis

Publikováno v: Journal of Molecular Neuroscience. 66:229-237

Mitochondrial dysfunctions mark a critical step in many central nervous system (CNS) pathologies, including multiple sclerosis (MS). Such dysfunctions lead to depolarization of mitochondrial membranes and imbalanced redox homeostasis. In this context

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9870a23565d64d2dbdc097000d260688
https://doi.org/10.1007/s12031-018-1159-2

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model

Autor: Tim Clarner, Markus Kipp, Adib Zendedel, M. Weißflog, T. Draheim, Athanassios Fragoulis, A. Liessem, Miriam Scheld, Christoph Jan Wruck, Cordian Beyer, Thomas W. Kensler, F. Wilms, Bernd Denecke

Publikováno v: Glia. 64:2219-2230

Oxidative stress critically contributes to the pathogenesis of a variety of neurodegenerative diseases such as multiple sclerosis. Astrocytes are the main regulators of oxidative homeostasis in the brain and dysregulation of these cells likely contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::166db862a07aa7a891741794bda8bbe6
https://doi.org/10.1002/glia.23058

Mitochondrial impairment in oligodendroglial cells induces cytokine expression and signaling

Autor: Tim Clarner, Adib Zendedel, Barbara Krauspe, Athanassios Fragoulis, Nico Teske, Markus Kipp, Cordian Beyer, Bernd Denecke, Miriam Scheld, Stella Nyamoya

Widespread inflammatory lesions within the central nervous system grey and white matter are major hallmarks of multiple sclerosis. The development of full-blown demyelinating multiple sclerosis lesions might be preceded by preactive lesions which are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f24e7395264227c3650681f58b019f
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/69551