Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Miriam Sansó"'
Autor:
Caterina Carbonell, Joan Frigola, Nuria Pardo, Ana Callejo, Patricia Iranzo, Augusto Valdivia, Ilaria Priano, Susana Cedrés, Alex Martinez‐Marti, Alejandro Navarro, Laura Lenza, Mireia Soleda, Javier Gonzalo‐Ruiz, Ana Vivancos, Miriam Sansó, Enric Carcereny, Teresa Morán, Ramon Amat, Enriqueta Felip
Publikováno v:
Molecular Oncology, Vol 17, Iss 5, Pp 779-791 (2023)
Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 axis are the main therapeutic option for patients with advanced non‐small cell lung cancer (NSCLC) without a druggable oncogenic alteration. Nevertheless, only a portion of patients b
Externí odkaz:
https://doaj.org/article/604e6cdc2d234a06b5347b1a01ff2632
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Cdk9 (P-TEFb) and its substrate Spt5 influence events throughout the transcription cycle. Here, the authors define two switches with the potential to regulate promoter-proximal pause release and termination, respectively containing phosphatases PP4 a
Externí odkaz:
https://doaj.org/article/8e61f919126a433ba10ee6df1e7aa926
Autor:
César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde, Jordi Rosell, Jonathan A. Fletcher, Suzanne George, Joan Carles, Joaquín Arribas
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT secondary mutations af
Externí odkaz:
https://doaj.org/article/9f289e7391be4b1faf8ff1a0d9f5ce87
Autor:
Fara Brasó-Maristany, Miriam Sansó, Nuria Chic, Débora Martínez, Blanca González-Farré, Esther Sanfeliu, Lucio Ghiglione, Esther Carcelero, Javier Garcia-Corbacho, Marcelo Sánchez, Dolors Soy, Pedro Jares, Vicente Peg, Cristina Saura, Montserrat Muñoz, Aleix Prat, Ana Vivancos
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The immune checkpoint inhibitor atezolizumab is approved for PD-L1-positive triple-negative breast cancer (TNBC). However, no activity of atezolizumab in PD-L1-negative TNBC has been reported to date. Here, we present the case study of a woman with T
Externí odkaz:
https://doaj.org/article/ed4b45258e414194b8958445070c4092
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
While post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 o
Externí odkaz:
https://doaj.org/article/fcb0fae25f044fe193746041c137258a
Autor:
Alexandra Santanach, Enrique Blanco, Hua Jiang, Kelly R. Molloy, Miriam Sansó, John LaCava, Lluis Morey, Luciano Di Croce
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of bo
Externí odkaz:
https://doaj.org/article/cf337e53504d4dbca5db1c546d985bc4
Autor:
Jorge Fernández-Vázquez, Itzel Vargas-Pérez, Miriam Sansó, Karin Buhne, Mercè Carmona, Esther Paulo, Damien Hermand, Miguel Rodríguez-Gabriel, José Ayté, Sebastian Leidel, Elena Hidalgo
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003647 (2013)
The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display transcriptional defects. However, it has also been shown that Elong
Externí odkaz:
https://doaj.org/article/b23a589a96094f04a8dcccbc61fd1b8b
Autor:
Miriam Sansó, Karen M Lee, Laia Viladevall, Pierre-Étienne Jacques, Viviane Pagé, Stephen Nagy, Ariane Racine, Courtney V St Amour, Chao Zhang, Kevan M Shokat, Beate Schwer, François Robert, Robert P Fisher, Jason C Tanny
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002822 (2012)
Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood.
Externí odkaz:
https://doaj.org/article/ac50f2f8315a444bae83530986674001
Autor:
Isabel A Calvo, Natalia Gabrielli, Iván Iglesias-Baena, Sarela García-Santamarina, Kwang-Lae Hoe, Dong Uk Kim, Miriam Sansó, Alice Zuin, Pilar Pérez, José Ayté, Elena Hidalgo
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6619 (2009)
BackgroundAn excess of caffeine is cytotoxic to all eukaryotic cell types. We aim to study how cells become tolerant to a toxic dose of this drug, and the relationship between caffeine and oxidative stress pathways.Methodology/principal findingsWe se
Externí odkaz:
https://doaj.org/article/471ade7ebfe54409a0bfa95fab07d3f7
Autor:
Caterina Carbonell, Joan Frigola, Nuria Pardo, Ana Callejo, Patricia Iranzo, Augusto Valdivia, Ilaria Priano, Susana Cedrés, Alex Martinez‐Marti, Alejandro Navarro, Laura Lenza, Mireia Soleda, Javier Gonzalo‐Ruiz, Ana Vivancos, Miriam Sansó, Enric Carcereny, Teresa Morán, Ramon Amat, Enriqueta Felip
Publikováno v:
Scientia
Immune checkpoint inhibitors; Liquid biopsy Inhibidores del punto de control inmunitario; Biopsia líquida Inhibidors del punt de control immunitari; Biòpsia líquida Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis are the main the