DEVEA: an interactive shiny application for Differential Expression analysis, data Visualization and Enrichment Analysis of transcriptomics data [version 2; peer review: 2 approved]

Autor: Solène Brohard, Carole Escartin, Eric Bonnet, Fernando Perez-Sanz, Jean-François Deleuze, Miriam Riquelme-Perez

Publikováno v: F1000Research, Vol 11 (2023)

We are at a time of considerable growth in transcriptomics studies and subsequent in silico analysis. RNA sequencing (RNA-Seq) is the most widely used approach to analyse the transcriptome and is integrated in many studies. The processing of transcri

Externí odkaz: https://doaj.org/article/4bf203283a36418e9c9a5d24f75a8a8e

Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

Autor: Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwenaelle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P. Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, 2022, ⟨10.1093/brain/awac068/6550082⟩

Huntington’s disease is a fatal neurodegenerative disease characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence of reactive astrocytes. Astrocytes are important partners for neurons and engage in a specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f88d3abc1e6f550b8912f6292213de5
https://doi.org/10.1101/2021.04.29.441924

Reactive astrocyte nomenclature, definitions, and future directions

Autor: Arthur M. Butt, Elena Galea, Richard M. Ransohoff, Raymond A. Swanson, Eduardo R. Zimmer, Christopher M. Norris, Gilles Bonvento, Andras Lakatos, Philip G. Haydon, Wei Ting Chen, Christine R. Rose, Alexey Semyanov, Nicola J. Allen, Anna V. Molofsky, Javier Vitorica, Seiji Okada, Alfonso Araque, Antonia Gutierrez, Masamitsu Iino, Alberto Serrano-Pozo, Vittorio Gallo, C. Justin Lee, Magdalena Götz, Baljit S. Khakh, Christian Steinhäuser, Bart De Strooper, Stéphane H. R. Oliet, Andrea Volterra, Swetlana Sirko, Kira E. Poskanzer, Michael V. Sofroniew, Giorgio Carmignoto, Elly M. Hol, Frank W. Pfrieger, Beatriz G. Pérez-Nievas, Ksenia V. Kastanenka, Keith K. Murai, James P. O'Callaghan, Ina B. Wanner, David H. Rowitch, Pierre J. Magistretti, Cinthia Farina, Marcela Pekna, Albee Messing, Jia Qian Wu, Shane A. Liddelow, Dieter Henrik Heiland, Anusha Mishra, Robert Zorec, Levi B. Wood, Marc R. Freeman, Matthew Holt, Luis Barbeito, Gabor C. Petzold, Luc Pellerin, Jeffrey D. Rothstein, Nathalie Rouach, Carole Escartin, Schuichi Koizumi, Gertrudis Perea, Dwight E. Bergles, Miriam Riquelme-Perez, Martine Cohen-Salmon, Stefanie Robel, James E. Goldman, Binhai Zheng, João Filipe Oliveira, Ari Barzilai, Steven A. Goldman, Brian A. MacVicar, Aude Panatier, Helmut Kettenmann, Alexei Verkhratsky, Amit Agarwal, Colm Cunningham, Blanca Diaz-Castro, Francisco J. Quintana, Milos Pekny, Harald Sontheimer, Benjamin Deneen, Vladimir Parpura

Publikováno v: Nature neuroscience 24(3), 312-325 (2021). doi:10.1038/s41593-020-00783-4
Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, G C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K K, Norris, C M, Okada, S, Oliet, S H R, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanzer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J D, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience, vol. 24, pp. 312–325 . https://doi.org/10.1038/s41593-020-00783-4
Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩
Nat Neurosci
Nature Neuroscience, Nature Publishing Group, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩
Nature neuroscience, vol 24, iss 3
Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩
Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, C C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K, Norris, C M, Okada, S, Oliet, S HR, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanazer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience . https://doi.org/10.1038/s41593-020-00783-4

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94bde53ce6b6eff445e92e9ff71c773