Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Miriam P. Kötzler"'
Autor:
Hong-Ming Chen, Lawrence P. McIntosh, Kyle Robinson, Stephen G. Withers, Mark Okon, Miriam P. Kötzler
Publikováno v:
Journal of the American Chemical Society. 140:8268-8276
Understanding the detailed mechanisms of enzyme-catalyzed hydrolysis of the glycosidic bond is fundamentally important, not only to the design of tailored cost-efficient, stable and specific catalysts but also to the development of specific glycosida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8c6e62d46352590b980e64716fbd8e
https://doi.org/10.1021/jacs.8b04235
https://doi.org/10.1021/jacs.8b04235
Publikováno v:
Protein Science. 26:1555-1563
Xylanases are important polysaccharide-cleaving catalysts for the pulp and paper, animal feeds and biofuels industries. They have also proved to be valuable model systems for understanding enzymatic catalysis, with one of the best studied being the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e807f9f366ba8a72d22ce743320929ac
https://doi.org/10.1002/pro.3181
https://doi.org/10.1002/pro.3181
Autor:
Stephen G. Withers, Miriam P. Kötzler
Publikováno v:
Journal of Biological Chemistry. 291:429-434
Proteolytic processing of human host cell factor 1 (HCF-1) to its mature form was recently shown, unexpectedly, to occur in a UDP-GlcNAc-dependent fashion within the transferase active site of O-GlcNAc-transferase (OGT) (Lazarus, M. B., Jiang, J., Ka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a42b2624da4c67e3a2d14ccb6c2f1a
https://doi.org/10.1074/jbc.c115.698696
https://doi.org/10.1074/jbc.c115.698696
Autor:
Eric Samain, Rafi Chapanian, Miriam P. Kötzler, Jayachandran N. Kizhakkedathu, Stephen G. Withers, David H. Kwan, Alisdair B. Boraston, Iren Constantinescu, Melanie A. Higgins
Publikováno v:
Journal of the American Chemical Society. 137:5695-5705
Blood transfusions are critically important in many medical procedures, but the presence of antigens on red blood cells (RBCs, erythrocytes) means that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e68d1d8883942efa954d48a10a7669a
https://doi.org/10.1021/ja5116088
https://doi.org/10.1021/ja5116088
Publikováno v:
Protein science : a publication of the Protein Society. 26(8)
Xylanases are important polysaccharide‐cleaving catalysts for the pulp and paper, animal feeds and biofuels industries. They have also proved to be valuable model systems for understanding enzymatic catalysis, with one of the best studied being the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::601086c3b1410e4776b88f24673295f6
https://pubmed.ncbi.nlm.nih.gov/28466501
https://pubmed.ncbi.nlm.nih.gov/28466501
Autor:
Edzard Spillner, Simon Blank, Miriam P. Kötzler, Frank I. Bantleon, Martin Wienke, Bernd Meyer
Publikováno v:
ACS Chemical Biology. 8:1830-1840
α1,6-Core-fucosyltransferase (FUT8) is a vital enzyme in mammalian physiological and pathophysiological processes such as tumorigenesis and progress of, among others, non-small cell lung cancer and colon carcinoma. It was also shown that therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dc25ad84a215611889f6568fec4b23
https://doi.org/10.1021/cb400140u
https://doi.org/10.1021/cb400140u
Autor:
Dirk Alpers, Henning N. Behnken, Bernd Meyer, Frank I. Bantleon, Edzard Spillner, Simon Blank, Miriam P. Kötzler
Publikováno v:
Insect Biochemistry and Molecular Biology. 42:116-125
Glycans of glycoproteins are often associated with IgE mediated allergic immune responses. Hymenoptera venoms, e.g., carry α1,3-fucosyl residues linked to the proximal GlcNAc of glycoproteins. This epitope, formed selectively by α1,3-fucosyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5af180b69c429d5da698ec8b1f551e
https://doi.org/10.1016/j.ibmb.2011.11.004
https://doi.org/10.1016/j.ibmb.2011.11.004
Autor:
Yi Jin, Jianbing Jiang, Miriam P. Kötzler, Hong-Ming Chen, David H. Kwan, Stephen G. Withers, Herman S. Overkleeft, Gideon J. Davies
Publikováno v:
FEBS letters, 590(4), 461-468
Covalent, mechanism-based inhibitors of glycosidases are valuable probe molecules for visualising enzyme activities in complex systems. We here describe the chemoenzymatic synthesis of 6-phospho-cyclophellitol and evaluate its behaviour as a mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c5fe3fead6969ac9df1a3405a2667e
https://pubmed.ncbi.nlm.nih.gov/26790390
https://pubmed.ncbi.nlm.nih.gov/26790390
Publikováno v:
Glycobiology. 25(8)
A facile enzymatic synthesis of the methylumbelliferyl β-glycoside of the type 2 A blood group tetrasaccharide in good yields is reported. Using this compound, we developed highly sensitive fluorescence-based high-throughput assays for both endo-β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461718a6ae0c1b4be8e4a2bbfa2a7daf
https://pubmed.ncbi.nlm.nih.gov/25964111
https://pubmed.ncbi.nlm.nih.gov/25964111
Publikováno v:
eLS
Glycosidases catalyse the hydrolysis of glycosidic linkages, thereby degrading oligosaccharides and glycoconjugates, the structurally most diverse class of biopolymers. These efficient and highly specific catalysts play important roles in biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250118ae723b7eeb28ba18ff33cf0e4c
https://doi.org/10.1002/9780470015902.a0020548.pub2
https://doi.org/10.1002/9780470015902.a0020548.pub2