Functional transcriptomic annotation and protein–protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer

Autor: Sandra Martínez‐Canales, Miguel López de Rodas, Miriam Nuncia‐Cantarero, Raquel Páez, Eitan Amir, Balázs Győrffy, Atanasio Pandiella, Eva María Galán‐Moya, Alberto Ocaña

Publikováno v: Cancer Medicine, Vol 7, Iss 5, Pp 1896-1907 (2018)

Abstract Although early stage ovarian cancer is in most cases a curable disease, some patients relapse even with appropriate adjuvant treatment. Therefore, the identification of patient and tumor characteristics to better stratify risk and guide rati

Externí odkaz: https://doaj.org/article/1808a90537044f01a46f0842ed995026

Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors.

Autor: Sara Morcillo-Garcia, Maria Del Mar Noblejas-Lopez, Cristina Nieto-Jimenez, Javier Perez-Peña, Miriam Nuncia-Cantarero, Balázs Győrffy, Eitan Amir, Atanasio Pandiella, Eva M Galan-Moya, Alberto Ocana

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0209134 (2019)

PurposeEpigenetic regulating proteins like histone methyltransferases produce variations in several functions, some of them associated with the generation of oncogenic processes. Mutations of genes involved in these functions have been recently assoc

Externí odkaz: https://doaj.org/article/a18737a86f8f4d71a6f7d17cfa41ddfe

Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer

Autor: Balázs Győrffy, Cristina Nieto-Jiménez, Miriam Nuncia-Cantarero, Alberto Ocaña, Verónica Corrales-Sánchez, Leticia Serrano-Oviedo, Eva María Galán-Moya, Miguel Burgos, Sara Morcillo-Garcia, Javier Pérez-Peña

Publikováno v: Cellular Oncology (Dordrecht)

Purpose Triple negative breast cancers (TNBCs) are enriched in cells bearing stem-like features, i.e., cancer stem cells (CSCs), which underlie cancer progression. Thus, targeting stemness may be an interesting treatment approach. The epigenetic mach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5594bc360933857a2f7e2fa32295bb
https://doi.org/10.1007/s13402-020-00497-6

Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer

Autor: Juan Carlos Montero, Sandra Martinez-Canales, Verónica Corrales-Sánchez, Ana Alcaraz-Sanabria, Eva María Galán-Moya, Atanasio Pandiella, Cristina Nieto-Jiménez, Miriam Nuncia-Cantarero, Miguel Burgos, Alberto Ocaña

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9034, p 9034 (2020)
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International Journal of Molecular Sciences
Volume 21
Issue 23

© 2020 by the authors.
Basal-like breast cancer is an incurable disease with limited therapeutic options, mainly due to the frequent development of anti-cancer drug resistance. Therefore, identification of druggable targets to improve current t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937f2176b892424c8f6a28c660bb3d67
https://www.mdpi.com/1422-0067/21/23/9034

Epigenetic mutational landscape in breast cancer: role of the histone methyltransferase gene KMT2D in triple negative tumors

Autor: Alberto Ocaña, Sara Morcillo García, Cristina Nieto-Jiménez, Eitan Amir, Balázs Győrffy, Miriam Nuncia-Cantarero, Javier Pérez-Peña, María Del Mar Noblejas-López, Eva María Galán-Moya, Atanasio Pandiella

Purpose: Epigenetic regulating proteins like histone methyltransferases produce variations in several functions, some of them associated with the generation of oncogenic processes. Mutations of genes involved in these functions have been recently ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f430489720e66146c3e2df990c84048a
https://doi.org/10.1101/486233