Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

Autor: Daniel Ramsbeck, Christoph Parthier, Hans-Ulrich Demuth, Stephan Schilling, Miriam Linnert, Michael Wermann, Martin Kleinschmidt, Claudia Fritz, Dagmar Schlenzig, Christian Jäger

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5651, p 5651 (2021)
Volume 22
Issue 11

The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7feb43d2e744a3a88ac52c537574ae1
http://europepmc.org/articles/PMC8197800

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis

Autor: Miriam Linnert, Stephan Schilling, Hans-Ulrich Demuth, Mirko Buchholz, Jens-Ulrich Rahfeld, John A. Houston, Christoph Parthier, Florian Veillard, Nadine Taudte, Anke Piechotta, Milton T. Stubbs, Petr Kolenko, Jan Potempa, Daniel Ramsbeck, Sigrun Eick

Publikováno v: The Journal of Biological Chemistry
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens-Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans-Ulrich; Stubbs, Milton T (2021). Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. The journal of biological chemistry, 296, p. 100263. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100263

The development of a targeted therapy would significantly improve the treatment of periodontitis and its associated diseases including Alzheimer's disease, rheumatoid arthritis, and cardiovascular diseases. Glutaminyl cyclases (QCs) from the oral pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b44849e5bf631c10995725a3bbf87c2
https://publica.fraunhofer.de/handle/publica/267517

Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation

Autor: Markus Geisler, Miriam Linnert, Anne Endler, Stephan Pollmann, Bangjun Wang, Sophie C. Oehring, Matthias Weiwad, Stefano Mancuso, Laurence Charrier, Aurélien Bailly, Jinsheng Zhu, Paolo Nanni, Alexander Schulz, Yoichiro Fukao, Sina Henrichs

Publikováno v: The EMBO Journal. 31:2965-2980

Polar transport of the plant hormone auxin is controlled by PIN- and ABCB/PGP-efflux catalysts. PIN polarity is regulated by the AGC protein kinase, PINOID (PID), while ABCB activity was shown to be dependent on interaction with the FKBP42, TWISTED D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6943e8995f1620cdaf706f476413ecfd
https://doi.org/10.1038/emboj.2012.120

The FKBP-type domain of the human aryl hydrocarbon receptor-interacting protein reveals an unusual Hsp90 interaction

Autor: Gunter Fischer, Anne-Katrin Paschke, Miriam Linnert, Annika Manns, Christian Lücke, Katja Haupt, Yi-Jan Lin, Matthias Weiwad

Publikováno v: Biochemistry. 52(12)

The aryl hydrocarbon receptor-interacting protein (AIP) has been predicted to consist of an N-terminal FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) domain and a C-terminal tetratricopeptide repeat (TPR) domain, as typically found in FK506-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847edf43ce74a8dd99796cabf51eb840
https://pubmed.ncbi.nlm.nih.gov/23418784