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pro vyhledávání: '"Miriam J. Müller"'
Publikováno v:
Journal of the American Society for Mass Spectrometry. 29:1456-1462
LC-MS/MS is widely utilized today for quantification of vitamin D in biological fluids. Mass spectrometric assays for vitamin D require very careful method optimization for precise and interference-free, accurate analyses however. Here, we explore ch
Activation of Reactive MALDI Adduct Ions Enables Differentiation of Dihydroxylated Vitamin D Isomers
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:2532-2537
Vitamin D compounds are secosteroids, which are best known for their role in bone health. More recent studies have shown that vitamin D metabolites and catabolites such as dihydroxylated species (e.g., 1,25- and 24,25-dihydroxyvitamin D3) play key ro
Publikováno v:
Talanta. 165:398-404
While the biological function of the 3α epimer of 25-hydroxyvitamin D 3 (25(OH)D 3 ) remains unknown, its presence needs to be accurately captured and separated from the main 3β epimer, to avoid positive bias in vitamin D status analyses. Several r
Publikováno v:
Analytical and Bioanalytical Chemistry. 409:2705-2714
Vitamin D measurements in biological fluids by mass spectrometry are challenging at very low concentration levels. As a result, chemical derivatization is often employed to enhance the ionization properties of low abundant vitamin D compounds. Cookso
Autor:
Simon Jitschin, Heiko Bruns, Leonhard Busch, Jens Nolting, Deniz Gezer, Rainer Boxhammer, Diana Dudziak, Bernd M. Spriewald, Christian P. Pallasch, Friedrich F. Hennig, Maike Büttner-Herold, Jörg Thomas Bittenbring, Dietrich A. Volmer, Frank Neumann, Andreas Mackensen, Markus H. Hoffmann, Christian Bach, Miriam J. Müller, Savita Bisht, Dimitrios Mougiakakos, Martin Böttcher, Heidi Balzer, Kolja Gelse, Mario Fabri, Fabian Beier
Publikováno v:
Leukemia. 32(11)
Macrophages are key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD38 antibody MOR202, currently introduced in multiple myeloma (MM) therapy. Therefore, it is important to understand how antibody-mediated ef
Publikováno v:
Talanta. 165
While the biological function of the 3α epimer of 25-hydroxyvitamin D
Publikováno v:
Scientific Reports
Most studies examining the relationships between vitamin D and disease or health focus on the main 25-hydroxyvitamin D3 (25(OH)D3) metabolite, thus potentially overlooking contributions and dynamic effects of other vitamin D metabolites, the crucial
Autor:
Miriam J. Müller, Dietrich A. Volmer
Publikováno v:
Clinical chemistry. 61(8)
BACKGROUNDThe frequency of measurements of vitamin D in the human population has significantly increased over the last decade because vitamin D has now been linked to many diseases, in addition to its established role in bone health. Usually, serum 2