Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis.

Autor: Miriam H P van Lieshout, Adam A Anas, Sandrine Florquin, Baidong Hou, Cornelis van't Veer, Alex F de Vos, Tom van der Poll

Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004368 (2014)

Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial for host defense against Klebsiella. Here we investigated the role of MyD88 in myeloid and e

Externí odkaz: https://doaj.org/article/21e726968b0c4203b56535869bd588d5

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis

Autor: Hanna K. de Jong, Miriam H. P. van Lieshout, Tassili A. F. Weehuizen, Emma Birnie, Andries E. Budding, Jacqueline M. Lankelma, Alex F. de Vos, Gavin C. K. W. Koh, W. Joost Wiersinga, Tom van der Poll, Joris J. T. H. Roelofs

Publikováno v: Infection and immunity, 87(8). American Society for Microbiology
Birnie, E, Weehuizen, T A F, Lankelma, J M, de Jong, H K, Koh, G C K W, van Lieshout, M H P, Roelofs, J J T H, Budding, A E, de Vos, A F, van der Poll, T & Wiersinga, W J 2019, ' Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis ', Infection and Immunity, vol. 87, no. 8, e00409 . https://doi.org/10.1128/IAI.00409-18
Infection and Immunity, 87(8):e00409. American Society for Microbiology

The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082d55c463094087eaf064a591c69b03
https://pure.amc.nl/en/publications/role-of-tolllike-receptor-5-tlr5-in-experimental-melioidosis(b9b9c146-0eb7-4b9c-b832-5d1e8de1b7cd).html

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia

Autor: Arie J. Hoogendijk, Cornelis van 't Veer, Adam A. Anas, Miriam H. P. van Lieshout, Sandrine Florquin, Jeroen W. J. van Heijst, Tom van der Poll, Alex F. de Vos, Zihai Li

Publikováno v: The Journal of Pathology. 238:74-84

Klebsiella pneumoniae is among the most common Gram-negative bacteria that cause pneumonia. Gp96 is an endoplasmic reticulum chaperone that is essential for the trafficking and function of Toll-like receptors (TLRs) and integrins. To determine the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce1ec276312982db27ece004a3692ae0
https://doi.org/10.1002/path.4637

Contents Vol. 7, 2015

Autor: Charles E. McCall, Mohamed El Gazzar, Melissa M. Berrien-Elliott, Cheng-Chin Kuo, Miriam H. P. van Lieshout, Diane Ly, Joseph C. Sun, Krishna Rajarathnam, Roberto P. Garofalo, Peter Chen, Zhi Q. Yao, Meng Li, Jude M. Taylor, Laura Brudecki, Renling Xu, Elena Sbrana, Eva Medina, Robert H. Cox, Tom van der Poll, Jian-Jie Li, Julia A. Wagner, Shuai Wang, Clara McClure, Hao Yan, Todd A. Fehniger, Sandrine Florquin, Hal K. Hawkins, Martina L. Sanderson-Smith, Alex F. de Vos, Druckerei Stückle, Manfred Rohde, Sebastian Voigt, James A. Tsatsaronis, Mark J. Walker, Oscar A. Aguilar, James R. Carlyle, Aleta Pupovac, Timothy E. O’Sullivan, Chong He, Hai-Qiong Yu, Ping-Chang Yang, Jaehun Ma, Aruz Mesci, Deepthi Kolli, Zhan-Ju Liu, David S.J. Allan, Joachim Hundrieser, Lei-Lei Fang, Cornelis vanʼt Veer, Rui-Jin Wu, Jing-Yiing Wu, Christina L. Kirkham, Satz Mengensatzproduktion, Oliver Goldmann, Kirti V. Sawant, Zhi-Gang Liu

Publikováno v: Journal of Innate Immunity. 7:I-IV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f17c9083f4d370839ad1a983fe5be951
https://doi.org/10.1159/000439388

TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis

Autor: Miriam H. P. van Lieshout, Cornelis van 't Veer, Tom van der Poll

Publikováno v: Inflammation research, 63(11), 927-933. Birkhauser Verlag Basel

To investigate the therapeutic effect of E5564 (a clinically used TLR4 inhibitor) in murine abdominal sepsis elicited by intraperitoneal infection with a highly virulent Escherichia coli in the context of concurrent antibiotic therapy. Mice were infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df24cc8a23e62ccbc0d22184faf207ee
https://doi.org/10.1007/s00011-014-0766-9