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pro vyhledávání: '"Miriam H Hernangomez"'
Autor:
Miriam Cnop, Laurence Ladrière, Lorella Marselli, Mariana Igoillo-Esteve, Piero Marchetti, Daniel Andrade Da Cunha, Miriam H Hernangomez, Baroj Abdulkarim
Publikováno v:
Endocrinology
Endocrinology, 158 (6
Endocrinology, 158 (6
Deficient as well as excessive/prolonged endoplasmic reticulum (ER) stress signaling can lead to pancreatic β cell failure and the development of diabetes. Saturated free fatty acids (FFAs) such as palmitate induce lipotoxic ER stress in pancreatic
Autor:
Lutgart Overbergh, Wannes D'Hertog, Rita Derua, Chantal Mathieu, Miriam Cnop, Michael Maris, Sofie Robert, Etienne Waelkens, Miriam H Hernangomez
Publikováno v:
Journal of proteome research. 12(1)
Sustained elevated levels of saturated free fatty acids, such as palmitate, contribute to beta cell dysfunction, a phenomenon aggravated by high glucose levels. The aim of this study was to investigate the mechanisms of palmitate-induced beta cell dy