Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Miriam Fontanillo"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Layer et al. present a crystal structure of Naa20, the catalytic subunit of an N-terminal acetyltransferase NatB, in complex with its competitive inhibitor CoA-Ac-MDEL. They find that Naa20 alone can acetylate NatB in vitro while Naa25, the auxiliary
Externí odkaz:
https://doaj.org/article/a463882788334edf964135dfeb200861
Autor:
Miriam Fontanillo, Malgorzata Trebacz, Christopher D. Reinkemeier, Daniela Avilés Huerta, Ulrike Uhrig, Peter Sehr, Maja Köhn
Publikováno v:
Bioorganicmedicinal chemistry. 65
PP1 is a major phosphoserine/threonine-specific phosphatase that is involved in diseases such as heart insufficiency and diabetes. PP1-disrupting peptides (PDPs) are selective modulators of PP1 activity that release its catalytic subunit, which then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb31dc010a110db24868a5a6a89701
https://pubmed.ncbi.nlm.nih.gov/35525109
https://pubmed.ncbi.nlm.nih.gov/35525109
Autor:
Bernhard Hoermann, Javier del Pino Garcia, Maja Köhn, Francesca Salvi, Orsolya Barabas, Miriam Fontanillo, Mathieu Bollen, Rita Derua, Monique Beullens
Publikováno v:
'ChemBioChem ', vol: 22, pages: 834-838 (2021)
Chembiochem
ChemBioChem
Chembiochem
ChemBioChem
Phosphoprotein phosphatase‐1 (PP1) is a key player in the regulation of phospho‐serine (pSer) and phospho‐threonine (pThr) dephosphorylation and is involved in a large fraction of cellular signaling pathways. Aberrant activity of PP1 has been l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745697fdb2291cc2548fd075fc1e3a31
https://lirias.kuleuven.be/handle/123456789/671428
https://lirias.kuleuven.be/handle/123456789/671428
Publikováno v:
Communications Biology
Communications biology 4(1), 2 (1-12) (2021). doi:10.1038/s42003-020-01546-4
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology 4(1), 2 (1-12) (2021). doi:10.1038/s42003-020-01546-4
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology 4(1), 2 (1-12) (2021). doi:10.1038/s42003-020-01546-4
N-terminal acetylation is one of the most common protein modifications in eukaryotes and is carried out by N-terminal acetyltransferases (NATs). It plays important role
N-terminal acetylation is one of the most common protein modifications in eukaryotes and is carried out by N-terminal acetyltransferases (NATs). It plays important role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3dbf5ab073d02e7e6c27d322d3165a
https://pubmed.ncbi.nlm.nih.gov/33398031
https://pubmed.ncbi.nlm.nih.gov/33398031
Autor:
Miriam Fontanillo, Maja Köhn
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1118-1126
Microcystins are highly toxic cyanotoxins responsible for plant, animal and human poisoning. Exposure to microcystins, mainly through drinkable water and contaminated food, is a current world health concern. Although it is quite challenging, the synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a061f118d225185969538bfe174db7c
https://doi.org/10.1016/j.bmc.2017.08.040
https://doi.org/10.1016/j.bmc.2017.08.040
Autor:
Valentin Wittmann, Maja Köhn, Miriam Fontanillo, Ivan Zemskov, Bernd Simon, Ulrike Uhrig, Maximilian Häfner, Francesca Salvi
Publikováno v:
Angewandte Chemie (International Ed. in English)
ResearcherID
ResearcherID
Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin (MC) natural toxins target both phosphatases with equal potency, and their complex synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717e5e455294831e1b3c0b2934e26930
https://pubmed.ncbi.nlm.nih.gov/27723199
https://pubmed.ncbi.nlm.nih.gov/27723199
Autor:
Miriam, Fontanillo, Maja, Köhn
Publikováno v:
Advances in experimental medicine and biology. 917
Phosphatases are involved in basically all cellular processes by dephosphorylating cellular components such as proteins, phospholipids and second messengers. They counteract kinases of which many are established oncogenes, and therefore kinases are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c15db22b29d7b490a568af74b47432d
https://pubmed.ncbi.nlm.nih.gov/27236558
https://pubmed.ncbi.nlm.nih.gov/27236558
Autor:
Maja Köhn, Miriam Fontanillo
Publikováno v:
Protein Targeting Compounds ISBN: 9783319224725
Advances in Experimental Medicine and Biology ISBN: 9783319328041
Advances in Experimental Medicine and Biology ISBN: 9783319328041
Phosphatases are involved in basically all cellular processes by dephosphorylating cellular components such as proteins, phospholipids and second messengers. They counteract kinases of which many are established oncogenes, and therefore kinases are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a365de8bec33dd5e61fb1a5eb2def39
https://doi.org/10.1007/978-3-319-22473-2_10
https://doi.org/10.1007/978-3-319-22473-2_10
Publikováno v:
Journal of colloid and interface science. 412
Hypothesis The reaction between succinic anhydride and a diamine derived from L -valine should afford efficiently a molecular gelator. Based on this reaction, it should be feasible to prepare molecular gels at room temperature, avoiding the conventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d4dcc57720420f72062a447c48b172
https://pubmed.ncbi.nlm.nih.gov/24144375
https://pubmed.ncbi.nlm.nih.gov/24144375