Area postrema neurons mediate interleukin-6 function in cancer cachexia

Autor: Qingtao Sun, Daniëlle van de Lisdonk, Miriam Ferrer, Bruno Gegenhuber, Melody Wu, Youngkyu Park, David A. Tuveson, Jessica Tollkuhn, Tobias Janowitz, Bo Li

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Interleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during cancer progression causes brain dysfunctions, which ultimately result in cachexia. However, how

Externí odkaz: https://doaj.org/article/0ffe8eb9112f497da2e4fea49fef27ae

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

Autor: Miriam Ferrer, Nicholas Mourikis, Emma E. Davidson, Sam O. Kleeman, Marta Zaccaria, Jill Habel, Rachel Rubino, Thomas R. Flint, Claire M. Connell, Michael Lukey, Eileen P. White, Anthony P. Coll, Ashok R. Venkitaraman, Tobias Janowitz

Publikováno v: bioRxiv

The dependency of cancer cells on glucose can be targeted with high-fat low-carbohydrate ketogenic diet (KD). However, hepatic ketogenesis is suppressed in IL-6 producing cancers, which prevents the utilization of this nutrient source as energy for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f8cbe42ba74f721a9de0d3f28804df
https://europepmc.org/articles/PMC9949105/

Abstract 1162: Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

Autor: Miriam Ferrer, Nicholas Mourikis, Emma E. Davidson, Sam O. Kleeman, Marta Zaccaria, Jill Habel, Rachel Rubino, Thomas R. Flint, Claire M. Connell, Michael J. Lukey, Eileen P. White, Anthony P. Coll, Ashok R. Venkitaraman, Tobias Janowitz

Publikováno v: Cancer Research. 83:1162-1162

The dependency of cancer cells on glucose can be targeted with high-fat low-carbohydrate ketogenic diet (KD). However, hepatic ketogenesis is suppressed in IL-6 producing cancers, which prevents the utilization of this nutrient source as energy for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbd14868647e4614eff036e90bfee503
https://doi.org/10.1158/1538-7445.am2023-1162

List of contributors

Autor: Claudia Abeijón-Mukdsi, Bharat B. Aggarwal, Aqsa Akhtar, Mohammad Alizadeh, Omar Al-Odat, Lourdes Amigo, Estefanía Andrada, Andrea Araiza-Calahorra, Waqas Asghar, Sadia Aslam, Javier Ávila-Román, Jana Baranda, Jalles Arruda Batista, Oumaima Ben-Romdhane, Revathi Boddu, Christine Boesch, Isabel Borras-Linares, Paz Soledad Robert Canales, Robert Chitren, Ivana M. Cotabarren, Edith-Oliva Cuevas-Rodríguez, Graziela Biude da Silva Duarte, Sevana Daneghian, Diva de Aguiar Magalhães, Alie de Boer, Tarcisio Vieira de Brito, Antonio Kleiton de Sousa, Fernando Mesquita de Sousa de Lima, Zoriţa M. Diaconeasa, Beatriz Díaz-Reinoso, Herminia Domínguez, André Luiz dos Reis Barbosa, Francisc V. Dulf, Samuel Fernández-Tomé, Helena Ferreira, Miriam Ferrer-Sierra, Jakub Fichna, Melinda Fogarasi, Carolina Fredes, Anca C. Frcaş, Morena Gabriele, Sara García-Gil, Paula García-Ibañez, Aurora García-Tejedor, Paola Gauffin-Cano, Daniela Giacomazza, Ana M. Gil, Juan Antonio Giménez-Bastida, Ilkay Gok, Jaime González-Romero, Francisco M. Goycoolea, Eduardo Jesús Guerra-Hernández, Alan Javier Hernández-Álvarez, Blanca Hernández-Ledesma, María Inés Isla, María Dolores Jiménez-Gordillo, Subash C. Jonnalagadda, Nauman Khalid, Penny M. Kris-Etherton, Satish Kumar, Vikas Kumar, Jose Moises Laparra, Karin G.M. Lenssen, Francisco Javier Leyva-Jiménez, Jesús Lozano-Sánchez, Antonela Marquez, Diana Martin, Adolfo J. Martinez-Rodriguez, Cristina Martínez-Villaluenga, Roxana Medina, Anamika Minhas, Martin Mondor, Antonia Montilla, M. Morante, Diego A. Moreno, Virginia Motilva, Nerea Muñoz-Almagro, Joaquín Navarro del Hierro, Ester S. Oh, Caroline Orfila, Miguel Oseguera-Toledo, Camila A. Palla, Manoj K Pandey, Elena Peñas, Cynthia Maria Carvalho Pereira, Kristina S. Petersen, Elisabete Pinto, Oana L. Pop, Sirima Puangpraphant, Laura Pucci, Bruna Zavarize Reis, Paloma Rodríguez-López, Azahara Rodríguez-Luna, Celia Rodríguez-Pérez, Marcelo Macedo Rogero, Connie J. Rogers, Matías Russo, Maciej Salaga, Antonio Segura-Carretero, Rakesh Sharma, Shweta Sharma, Jose Manuel Silvan, Sonia A. Socaci, Stefany Guimarães Sousa, Marcin Talar, Elena Talero, Aleksandra Tarasiuk, Irene Tomé-Sánchez, Hafiz Ubaid ur Rahman, Marta W. Vasconcelos, Mar Villamiel, Max Von Suskil, Iris Catiana Zampini, Longli Zhou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::484e962e889245bf2d548225f4d7fc51
https://doi.org/10.1016/b978-0-12-823482-2.00035-2

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

Autor: Timotheus Y.F. Halim, Shwethaa Raghunathan, Tobias Janowitz, Erwin F. Wagner, Martijn J. Schuijs, Duncan I. Jodrell, Michele Petruzzelli, Michele Vacca, Christian Frezza, Zoe Hall, David Perera, Edoardo Gaude, Miriam Ferrer, Ashok R. Venkitaraman, Michael J. Lukey

An elevated neutrophil-to-lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, we show using murine model systems of colorectal and pancreatic cancer that neutr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6d1675fc35cbbd4f83849c18c3ee51c
https://doi.org/10.1101/2021.08.11.455851