Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Miriam F. Bryant"'
Autor:
Nana Nikolaishvili-Feinberg, Marila Cordeiro-Stone, Dennis A. Simpson, Timothy P. Heffernan, Miriam F. Bryant, William K. Kaufmann, Douglas D. Luche, Fumio Hanaoka, Nicole M. King
Publikováno v:
DNA Repair. 4:714-724
Telomerase-immortalized lines of diploid xeroderma pigmentosum variant (XP-V) fibroblasts (XP115LO and XP4BE) were complemented for constitutive or regulated expression of wild-type human DNA polymerase eta (hpol eta). The ectopic gene was expressed
Autor:
Marila Cordeiro-Stone, Lisa D. McDaniel, Miriam F. Bryant, William K. Kaufmann, Stephanie B. Hatch, Ikechukwu Oguejiofor, Alexandra R. Frank
Publikováno v:
Carcinogenesis. 23:959-966
Lack of DNA polymerase eta and the attendant defect in bypass replication of pyrimidine dimers induced in DNA by ultraviolet light (UV) underlie the enhanced mutagenesis and carcinogenesis observed in xeroderma pigmentosum variant (XP-V). We investig
Autor:
J. K. McGee, Gregory L. Erexson, Carolyn L. Doerr, Puntipa Kwanyuen, Miriam F. Bryant, Andrew D. Kligerman
Publikováno v:
Environmental and Molecular Mutagenesis. 23:186-189
Phosphine (PH3) is a highly toxic grain fumigant that can be produced from the reaction of metal phosphides with water. To determine the in vivo cytogenetic effects of inhalation of PH3, male CD-1 mice were exposed to either 0, 5, 10, or 15 ppm targe
Autor:
Marc R. Sontag, Andrew D. Kligerman, Miriam F. Bryant, Edward C. Halperin, Gregory L. Erexson
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 253:193-198
The study compared the radiosensitivity of human, rat and mouse peripheral blood lymphocytes (PBLs) by analyzing micronuclei (MN) in cytochalasin B-induced binucleated (BN) cells. For each species and dose 4-ml aliquots of whole blood were X-irradiat
Autor:
Gregory L. Erexson, Kerry L. Dearfield, Miriam F. Bryant, Andrew D. Kligerman, Puntipa Kwanyuen, A.L. Atwater
Publikováno v:
Mutagenesis. 6:137-141
The clastogenicity of ethyl acrylate (EA) was examined in vivo by injecting i.p. five male C57BL/6 mice per dose group with either 125, 250, 500 or 1000 mg/kg EA dissolved in saline. Controls received solvent only. Acrylamide (100 mg/kg), because of
Autor:
Lakshmi Pendyala, Suzanne Hector, Miriam F. Bryant, Nicole M. King, Stephen G. Chaney, Ekaterina Bassett, Marila Cordeiro-Stone
Publikováno v:
Cancer research. 64(18)
Cisplatin, a widely used chemotherapeutic agent, has been implicated in the induction of secondary tumors in cancer patients. This drug is presumed to be mutagenic because of error-prone translesion synthesis of cisplatin adducts in DNA. Oxaliplatin
Autor:
Yingchun Zhou, Nana Nikolaishvili-Feinberg, Marila Cordeiro-Stone, William K. Kaufmann, Miriam F. Bryant, Alexandra R. Frank, Lea M. Beaulieu, Douglas D. Luche, Timothy P. Heffernan, Sharon C. Doherty, Tong Zhou, Dennis A. Simpson
Publikováno v:
Mutation research. 532(1-2)
The ability of caffeine to reverse cell cycle checkpoint function and enhance genotoxicity after DNA damage was examined in telomerase-expressing human fibroblasts. Caffeine reversed the ATM-dependent S and G2 checkpoint responses to DNA damage induc
Publikováno v:
Environmental and molecular mutagenesis. 25(1)
The sensitivity to micronucleus (MN) induction of human, mouse, and rat peripheral blood lymphocytes (PBLs) exposed to bleomycin sulfate (BLM) in vitro was compared in cytochalasin B-induced binucleated (BN) cells. For the PBLs of each species, eithe
Autor:
J. K. McGee, Carolyn L. Doerr, Andrew D. Kligerman, Gregory L. Erexson, Miriam F. Bryant, Puntipa Kwanyuen, P.A. Evansky
Publikováno v:
Mutation research. 322(2)
Trichloroethylene (TCE) (CAS No. 79-01-6) is an industrial solvent used in degreasing, dry cleaning, and numerous other medical and industrial processes. Controlled inhalation studies were performed using male C57BL/6 mice and CD rats to determine if
Autor:
Andrew C. Beach, Ramesh C. Gupta, Miriam F. Bryant, Jeffrey A. Ross, Garret B. Nelson, Katrina L. Holden, Stephen Nesnow, Karen Earley, Gregory L. Erexson, Andrew D. Kligerman
Publikováno v:
Carcinogenesis. 13(10)
Benzo[b]fluoranthene (B[b]F) was administered (100 mg/kg by i.p. injection) to male Sprague--Dawley rats. Lungs, livers and peripheral blood lymphocytes (PBLs) were harvested 1, 3, 5, 7, 14, 28 and 56 days after treatment. Several DNA adducts were ob