Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Miriam F Moffatt"'
Autor:
Leah Cuthbertson, Stephen W C Oo, Michael J Cox, Siew-Kim Khoo, Des W Cox, Glenys Chidlow, Kimberley Franks, Franciska Prastanti, Meredith L Borland, James E Gern, David W Smith, Joelene A Bizzintino, Ingrid A Laing, Peter N Le Souëf, Miriam F Moffatt, William O C Cookson
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223990 (2019)
Acute viral wheeze in children is a major cause of hospitalisation and a major risk factor for the development of asthma. However, the role of the respiratory tract microbiome in the development of acute wheeze is unclear. To investigate whether seve
Externí odkaz:
https://doaj.org/article/9744bb3b496547a790bdfc405d1bc6f7
Autor:
Steven A Cowman, Phillip James, Robert Wilson, William O C Cookson, Miriam F Moffatt, Michael R Loebinger
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208018 (2018)
The diagnosis of pulmonary non-tuberculous mycobacterial disease (pNTM) is dependent on the isolation of NTM in culture, which is prone to overgrowth and contamination and may not capture the diversity of mycobacteria present, including rare or unide
Externí odkaz:
https://doaj.org/article/df4214ce644b497b99669afcad768f72
Autor:
Bushra Ahmed, Michael J Cox, Leah Cuthbertson, Phillip L James, William O C Cookson, Jane C Davies, Miriam F Moffatt, Andrew Bush
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201156 (2018)
RATIONALE:The lower airway microbiota is important in normal immunological development and chronic lung diseases (CLDs). Young children cannot expectorate and because of the uncertainty whether upper airway samples reflect the lower airway microbiota
Externí odkaz:
https://doaj.org/article/d0aa6478a24f42efb188d4a7dbf6f231
Autor:
Despoina Manousaki, Lavinia Paternoster, Marie Standl, Miriam F Moffatt, Martin Farrall, Emmanuelle Bouzigon, David P Strachan, Florence Demenais, Mark Lathrop, William O C M Cookson, J Brent Richards
Publikováno v:
PLoS Medicine, Vol 14, Iss 5, p e1002294 (2017)
BackgroundLow circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological associations, if true, would have public health importance, since vitamin D insuf
Externí odkaz:
https://doaj.org/article/a6294275a6eb4205b09a659d25c208ad
Autor:
Michael J Cox, Elena M Turek, Catherine Hennessy, Ghazala K Mirza, Phillip L James, Meg Coleman, Andrew Jones, Robert Wilson, Diana Bilton, William O C Cookson, Miriam F Moffatt, Michael R Loebinger
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170622 (2017)
BACKGROUND:Bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. However, the evidence base for antibiotic therapy is limited. DNA based methods offer better identification and quantification of microbial co
Externí odkaz:
https://doaj.org/article/e8c2345d2df24e73b5d786c88430113e
Autor:
Leah Cuthbertson, Vanessa Craven, Lynne Bingle, William O C M Cookson, Mark L Everard, Miriam F Moffatt
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190075 (2017)
Persistent bacterial bronchitis (PBB) is a leading cause of chronic wet cough in young children. This study aimed to characterise the respiratory bacterial microbiota of healthy children and to assess the impact of the changes associated with the dev
Externí odkaz:
https://doaj.org/article/96343d68e8284e9babc3f1d1a99ca0a1
Autor:
Chih-Yung Chiu, Saffron A. G. Willis-Owen, Kenny C.C. Wong, Stuart N. Farrow, William O.C. Cookson, Miriam F. Moffatt, Youming Zhang
Publikováno v:
Journal of Inflammation, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Background We have previously discovered clusters of sequentially negative and positive modulators of acute inflammation during cytokine stimulation in epithelial cells and identified potential targets for therapy within these clusters. MAP3
Externí odkaz:
https://doaj.org/article/c9ee6389a88948abba576af5ba381549
Autor:
Suzanne Miller, Amanda P Henry, Emily Hodge, Alexander K Kheirallah, Charlotte K Billington, Tracy L Rimington, Sangita K Bhaker, Ma'en Obeidat, Erik Melén, Simon K Merid, Caroline Swan, Catherine Gowland, Carl P Nelson, Ceri E Stewart, Charlotte E Bolton, Iain Kilty, Anders Malarstig, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Ian P Hall, Ian Sayers
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164041 (2016)
Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encodin
Externí odkaz:
https://doaj.org/article/fddddc60e55d4be390faa9c32649f704
Autor:
Alexander G Shaw, Kathleen Sim, Paul Randell, Michael J Cox, Zoë E McClure, Ming-Shi Li, Hugo Donaldson, Paul R Langford, William O C M Cookson, Miriam F Moffatt, J Simon Kroll
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132923 (2015)
BACKGROUND:Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening consequences. We sought to identify clinical characteristics and microbial signatures i
Externí odkaz:
https://doaj.org/article/a316d48b9fb04e33bec7607229731e69
Autor:
Leah Cuthbertson, Ulrike Löber, Jonathan S. Ish-Horowicz, Claire N. McBrien, Colin Churchward, Jeremy C. Parker, Michael T. Olanipekun, Conor Burke, Aisling McGowan, Gwyneth A. Davies, Keir E. Lewis, Julian M. Hopkin, Kian Fan Chung, Orla O’Carroll, John Faul, Joy Creaser-Thomas, Mark Andrews, Robin Ghosal, Stefan Piatek, Saffron A. G. Willis-Owen, Theda U. P. Bartolomaeus, Till Birkner, Sarah Dwyer, Nitin Kumar, Elena M. Turek, A. William Musk, Jennie Hui, Michael Hunter, Alan James, Marc-Emmanuel Dumas, Sarah Filippi, Michael J. Cox, Trevor D. Lawley, Sofia K. Forslund, Miriam F. Moffatt, William. O. C. Cookson
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors. Freed of selection to digest nutrients, the airway microbiome underpins cognate management o
Externí odkaz:
https://doaj.org/article/fa0a86718fb4447f9b20ab7e4ec9f322