Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Miriam E. Bucheli"'
Autor:
Jessica L Dermody, Jonathan M Dreyfuss, Judit Villén, Babatunde Ogundipe, Steven P Gygi, Peter J Park, Alfred S Ponticelli, Claire L Moore, Stephen Buratowski, Miriam E Bucheli
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3273 (2008)
The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S. cerevisiae SR-like protein Npl3 functions to negatively regulat
Externí odkaz:
https://doaj.org/article/e7cc1d51db8c434ebda3c455aa7743c1
Autor:
Stephen Buratowski, Miriam E. Bucheli
Publikováno v:
The EMBO Journal. 24:2150-2160
Proper 3′ end formation is critical for the production of functional mRNAs. Termination by RNA polymerase II is linked to mRNA cleavage and polyadenylation, but it is less clear whether earlier stages of mRNA production also contribute to transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b5263867645dd9723e71a896669d6c
https://doi.org/10.1038/sj.emboj.7600687
https://doi.org/10.1038/sj.emboj.7600687
Autor:
Johnny Salameh, James D. Berry, Nazem Atassi, Amelia Calderón, Miriam E. Bucheli, Diana Chicaiza, Elise Digga, Ricardo López, Carolina Franco
Publikováno v:
Neurology. 81:1959-1961
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing motor neuron loss and weakness. Worldwide prevalence is 4-6/100,000. Incidence is 1.5-2.7/100,000 per year and may be increasing. Studies suggest race and ethnicity affect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5841855df1e57e76c00b5d4fdbce10e1
https://doi.org/10.1212/01.wnl.0000436610.28210.a5
https://doi.org/10.1212/01.wnl.0000436610.28210.a5
Publikováno v:
Scopus-Elsevier
Nucleotide excision repair (NER) is an evolutionarily conserved pathway that removes DNA damage induced by ultraviolet irradiation and various chemical agents that cause bulky adducts. Two subpathways within NER remove damage from the genome overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c8fb27d373b2c72b5cb216540d0a36
https://doi.org/10.1093/genetics/158.3.989
https://doi.org/10.1093/genetics/158.3.989
Autor:
Andres Andino, Mayra Montalvo, Nazem Atassi, Miriam E. Bucheli, Johnny Salameh, James D. Berry, Jose Cruz
Publikováno v:
Amyotrophic lateral sclerosisfrontotemporal degeneration. 15(1-2)
Recent studies suggest amyotrophic lateral sclerosis (ALS) prevalence, incidence, and age of onset are heterogeneous across populations. These include studies from South America (SA) where lower prevalence, earlier onset, and reduced survival time of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16171f53d45b1b52be2c74f9f2a043e3
https://pubmed.ncbi.nlm.nih.gov/24245684
https://pubmed.ncbi.nlm.nih.gov/24245684
Autor:
Stephen Buratowski, Alfred S. Ponticelli, Steven P. Gygi, Jonathan M. Dreyfuss, Babatunde Ogundipe, Judit Villén, Claire Moore, Miriam E. Bucheli, Jessica L. Dermody, Peter J. Park
Publikováno v:
PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3273 (2008)
PLoS ONE, Vol 3, Iss 9, p e3273 (2008)
The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S. cerevisiae SR-like protein Npl3 functions to negatively regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4199c6b685a633f7309b3f41e73ec
https://pubmed.ncbi.nlm.nih.gov/18818768
https://pubmed.ncbi.nlm.nih.gov/18818768
Multiple steps in mRNA processing and transcription are coupled. Notably, the processing of mRNA 3′ ends is linked to transcription termination by RNA polymerase II. Previously, we found that the yeast hnRNP protein Npl3 can negatively regulate 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058c9ce71bfa7e68fd75eb348282d9ec
https://europepmc.org/articles/PMC1986811/
https://europepmc.org/articles/PMC1986811/
Publikováno v:
Journal of molecular biology. 375(1)
Yeast Npl3 is homologous to SR proteins in higher eukaryotes, a family of RNA-binding proteins that have multiple essential roles in RNA metabolism. This protein competes with 3′-end processing factors for binding to the nascent RNA, protecting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a6becf264da9600e6d7113daac7200
https://pubmed.ncbi.nlm.nih.gov/18022637
https://pubmed.ncbi.nlm.nih.gov/18022637
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(16)
Cockayne's syndrome cells lack transcription-coupled nucleotide excision repair (TCR) and ubiquitylation of RNA polymerase II large subunit (RNA pol II LS), suggesting that ubiquitylation of RNA pol II LS may be necessary for TCR in eukaryotes. Rsp5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43d555526883470f5de42cb829a7d9b
https://pubmed.ncbi.nlm.nih.gov/10900266
https://pubmed.ncbi.nlm.nih.gov/10900266