Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Miriam Del Prado"'
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
The concentrations of LSN3154567 in the dog plasma samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e6822518f21d94bca7c1d9980cb9dc
https://doi.org/10.1158/1535-7163.22510030.v1
https://doi.org/10.1158/1535-7163.22510030.v1
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aee608d35f9d18aa0d631046f9435f6
https://doi.org/10.1158/1535-7163.c.6539479
https://doi.org/10.1158/1535-7163.c.6539479
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Table S1: anti-proliferative activity of LSN3154567 against different cancer cell lines; Table S2: effects of NAM on the anti-proliferative activity of LSN3154567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f70612a84c12c12c5e1209c6248e3b6
https://doi.org/10.1158/1535-7163.22510024
https://doi.org/10.1158/1535-7163.22510024
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Addition of NA rescued the inhibitory activity of LSN3154567.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ceca73088ab401f7f49c9843a276a7
https://doi.org/10.1158/1535-7163.22510042
https://doi.org/10.1158/1535-7163.22510042
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Addition of NAM rescued the inhibitory activity of LSN3154567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bcb7f006df51f1b22045b2d1feaf1e
https://doi.org/10.1158/1535-7163.22510036
https://doi.org/10.1158/1535-7163.22510036
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Association of NAPRT1 expression level with sensitivity of cancer cells to NAMPT inhibition by LSN3154567 in the presence of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de57bd307d5cde24b259e24180abd7b6
https://doi.org/10.1158/1535-7163.22510027.v1
https://doi.org/10.1158/1535-7163.22510027.v1
Autor:
Burkholder Timothy P, Maria-Carmen Fernandez, Gillig James Ronald, Lourdes Prieto, Miriam del Prado, Bo Tan, Genshi Zhao, Tao Wang, Robert L. Johnson, Yu-Hua Hui, Ken D. Roth, Shobha N. Bhattachar, Sean Buchanan, Xueqian Gong, Sandaruwan Geeganage, Robert L. Shepard, Ming-Shang Kuo, Colin F. Green, Lisa Kays, Wenjuan Wu, Sucai Dong
Publikováno v:
Molecular Cancer Therapeutics. 16:2677-2688
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Autor:
Brian M. Arnold, Miriam del Prado, Smriti Iyengar, Edward L. Mattiuz, Zhipei Wu, Mark A. Winter, David Bleakman, Ken H. Ho, Ann Marie L. Ogden, Paul L. Ornstein, Carrie K. Jones, Sandra Ann Filla, Brian Michael Mathes, Michael Gregory Bell, Douglas Richard Stack, Ana Maria Escribano, Thomas J. Bleisch, Ana I. Mateo, Kevin John Hudziak, Andrew Alt, Rosa Maria A. Simmons, Harlan E. Shannon, Robert E. Stratford, Jose A. Martinez-Perez, Esteban Dominguez, Ana M. Castaño
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6459-6462
The synthesis and structure-activity relationship of decahydroisoquinoline derivatives with various benzoic acid substitutions as GluK1 antagonists are described. Potent and selective antagonists were selected for a tailored prodrug approach in order
Autor:
Edward L. Mattiuz, Ann Marie L. Ogden, Ana M. Castaño, Zhipei Wu, Robert E. Stratford, E. Dominguez, Thomas J. Bleisch, Brian Michael Mathes, Brian M. Arnold, David Bleakman, Smriti Iyengar, Rosa Maria A. Simmons, Harlan E. Shannon, Sandra Ann Filla, Jose A. Martinez-Perez, Douglas Richard Stack, Ana I. Mateo, Miriam del Prado, Kevin John Hudziak, Andrew Alt, Michael Gregory Bell, Carrie K. Jones, Paul L. Ornstein, Jennifer L. Buckmaster, Ana Maria Escribano, Mark A. Winter, Ken H. Ho
Publikováno v:
Journal of Medicinal Chemistry. 48:4200-4203
Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 and 8 were orally active in three models of pain: reversal of forma
Autor:
and Lea M. Johnson, Bryan D. Anderson, Paul Lee, Miriam del Prado, C. Richard NevillJr., Sehila Pleite, Yong Wang, † Jaime Blanco-Urgoiti, Luisa M. Martín Cabrejas, Jeremy Schulenburg York, Robert M. Campbell, Deborah D. Giera, Michal Vieth, Jeffrey A. Wolos, Denis J. McCann, Chuan Shih, Li C. Li, Beatriz López de Uralde, Nicholas A. Magnus, Concepción Sánchez, Rosanne Bonjouklian, Richard M. Schultz, María José Lorite, Alfonso De Dios
Publikováno v:
Journal of Medicinal Chemistry. 48:2270-2273
We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had low-nanomolar activity in both ATP competitive enzyme binding and inhibition of TNFalpha release in m