Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Miriam D. Kleinman"'
Autor:
Bonnie F. Sloane, Jonathan W. Wojtkowiak, John J. Reiners, Komal M. Sane, Raymond R. Mattingly, Miriam D. Kleinman
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:65-74
Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-14, and NF90-8 to nanomolar concentrations of both lovastatin and farnesyl transferase inhibitor (FTI)-1 but not to either drug alone induced cell death. ST88-14 a
Publikováno v:
Free Radical Biology and Medicine. 50:281-294
Reactive oxygen species (ROS) can induce lysosomal membrane permeabilization (LMP). Photoirradiation of murine hepatoma 1c1c7 cultures preloaded with the photosensitizer NPe6 generates singlet oxygen within acidic organelles, and causes LMP and the a
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:796-806
The therapeutic usefulness of the quinoxaline derivatives XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid) has been attributed to their abilities to induce G2/M arrest
Autor:
Raymond R. Mattingly, Daniel T. LaLonde, Richard A. Gibbs, John J. Reiners, Farid S. Fouad, Jonathan W. Wojtkowiak, Richard F. Borch, Miriam D. Kleinman
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:1-11
Neurofibromatosis type 1 (NF1) is a genetic disorder that is driven by the loss of neurofibromin (Nf) protein function. Nf contains a Ras-GTPase-activating protein domain, which directly regulates Ras signaling. Numerous clinical manifestations are a