Výsledky vyhledávání - "Miriam Chebli"

Akademický článek

Mechanism of partial agonism in AMPA-type glutamate receptors

Autor: Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.

Externí odkaz: https://doaj.org/article/299882cd5dc14ccfb46ea49f3ccbb9ae

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The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors

Autor: Miriam Chebli, Jelena Baranovic, Andrew J.R. Plested, Sebastian Braunbeck, Zaki N, Minniberger S

Publikováno v: Baranovic, J, Braunbeck, S, Zaki, N, Minniberger, S, Chebli, M & Plested, A 2022, ' The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors ', Journal of General Physiology, vol. 154, no. 5, e202112912 . https://doi.org/10.1085/jgp.202112912
bioRxiv

SummaryConotoxins are a large group of naturally occurring toxic peptides produced by the predatory sea snails of the genus Conus. Many of these toxins target ion channels, often with high specificity and affinity. As such, they have proven to be inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fa5f96eb9bfdfa62075161e9b82d29
https://www.pure.ed.ac.uk/ws/files/260749383/jgp_202112912_1_.pdf

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Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation

Autor: Katja Faelber, Jelena Baranovic, Miriam Chebli, Héctor Jiménez Salazar, Andrew J.R. Plested, Oliver Daumke, Anna L. Carbone, Albert Y. Lau

Publikováno v: Biophysical journal, 110(4): 896–911

Ionotropic glutamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excitatory transmission. Glutamate binding to clamshell-shaped ligand binding domains (LBDs) triggers opening of the integral ion channel, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b65f18fea15f69c5dde3413d841a76
https://doi.org/10.1016/j.bpj.2015.12.033

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Mechanism of partial agonism in AMPA-type glutamate receptors

Autor: Andrew J.R. Plested, Miriam Chebli, Hector Salazar, Clarissa Eibl

Publikováno v: Nature Communications
Nature Communications, 8:14327
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Neurotransmitters trigger synaptic currents by activating ligand-gated ion channel receptors. Whereas most neurotransmitters are efficacious agonists, molecules that activate receptors more weakly—partial agonists—also exist. Whether these partia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfde51d577b926d1de4ba2763421d179
https://refubium.fu-berlin.de/handle/fub188/20833

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Partial Agonist Binding Reveals a Unique Arrangement of AMPA LBDs

Autor: Hector P. Salazar Garcia, Clarissa Ebli, Miriam Chebli, Andrew J.R. Plested

Publikováno v: Biophysical Journal. 108(2)

Ionotropic glutamate receptors (iGluRs) are large tetrameric membrane proteins that transduce the chemical signal from neurotransmitters into membrane depolarization at synapses in the brain. The conformational transition induced by the association o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752c97460d1006a6da84448fb33e0f4f

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The endothelium-derived contracting factor uridine adenosine tetraphosphate induces P2Y(2)-mediated pro-inflammatory signaling by monocyte chemoattractant protein-1 formation

Autor: Markus van der Giet, Markus Tölle, J. Prüfer, Monika Schäfer-Korting, Tao Huang, Vera Jankowski, Walter Zidek, Mirjam Schuchardt, Joachim Jankowski, Miriam Chebli, Annette Wiedon, Nicole Prüfer

Publikováno v: Journal of molecular medicine (Berlin, Germany). 89(8)

It is very well established that purinergic signaling plays a relevant role in vascular physiology and pathophysiology. Recently, a new purinoceptor agonist uridine adenosine tetraphosphate (Up(4)A) has been identified as a highly potent endothelial-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9038d880d92dd687e204310f1c6265b0
https://pubmed.ncbi.nlm.nih.gov/21487675

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Activation of Ligand Binding Domains of an AMPA-Type Glutamate Receptor

Autor: Katja Faelber, Jelena Baranovic, Oliver Daumke, Albert Y. Lau, Andrew J.R. Plested, Valentina Ghisi, Miriam Chebli, Hector Salazar

Publikováno v: Biophysical Journal. 106:29a

Ionotropic glutamate receptors are postsynaptic tetrameric channels whose activity mediates transmission of the synaptic signal. Binding of glutamate to their ligand binding domains (LBDs) shifts the receptors from the resting to active state followe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8405338b50e5ec2ae93f5c2f59045b
https://doi.org/10.1016/j.bpj.2013.11.216

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Dissecting the Activation of AMPA Receptors

Autor: Oliver Daumke, Miriam Chebli, Jelena Baranovic, Hector Salazar, Andrew J.R. Plested, Katja Faelber, Valentina Ghisi

Publikováno v: Biophysical Journal. 104:272a

Ionotropic glutamate receptors are tetrameric ion channels that are activated by the neurotransmitter glutamate at excitatory synapses. It is known that after the binding of glutamate, the AMPA-subtype of glutamate receptors transits through distinct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3438f7dae57a306720bf227e8c6ee1
https://doi.org/10.1016/j.bpj.2012.11.1525

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