Výsledky vyhledávání - "Miriam C, Poirier"

Akademický článek

WR1065 conjugated to thiol-PEG polymers as novel anticancer prodrugs: broad spectrum efficacy, synergism, and drug resistance reversal

Autor: Dale M. Walker, Tsvetelina I. Lazarova, Steven W. Riesinger, Miriam C. Poirier, Terri Messier, Brian Cunniff, Vernon E. Walker

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

The lack of anticancer agents that overcome innate/acquired drug resistance is the single biggest barrier to achieving a durable complete response to cancer therapy. To address this issue, a new drug family was developed for intracellular delivery of

Externí odkaz: https://doaj.org/article/f4c45ff1604b44f9a8e00b84babc041b

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Association between zidovudine-containing antiretroviral therapy exposure in utero and leukocyte telomere length at birth

Autor: Carmen J. Marsit, Miriam C. Poirier, Sean S Brummel, Mitchell J. Machiela, Sharon A. Savage, Casey L. Dagnall, Ellen G. Chadwick, Eric A. Engels, Youjin Wang, Deborah Kacanek, Stephen J. Chanock, Rohan Hazra, Erin Beilstein-Wedel

Publikováno v: AIDS

Zidovudine (ZDV) is a nucleoside reverse transcriptase inhibitor that could cause telomere shortening through inhibition of telomerase. We examined the association between in utero exposure to ZDV and telomere length at birth in HIV-exposed-uninfecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c30d6865c2d36c6cf916e6fa86c31f8
https://doi.org/10.1097/qad.0000000000002317

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In vivo localization and postmortem stability of benzo[ a ]pyrene‐DNA adducts

Autor: Michelle Vanlandingham, Kathyayini V. Divi, Daniel Martineau, Jennifer E. Dwyer, Miriam C. Poirier, Alyssa L. Damon, Linda S. Von Tungeln, Rao L. Divi, Mehnaz Ali, Frederick A. Beland, Mona I. Churchwell, Guy Beauchamp

Publikováno v: Environmental and Molecular Mutagenesis. 61:216-223

DNA adducts of carcinogenic polycyclic aromatic hydrocarbons (PAHs) play a critical role in the etiology of gastrointestinal tract cancers in humans and other species orally exposed to PAHs. Yet, the precise localization of PAH-DNA adducts in the gas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874ad639d170a98ef8e29762d201b9cc
https://doi.org/10.1002/em.22337

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Akademický článek

Exposure of Allium cepa root cells to zidovudine or nevirapine induces cytogenotoxic changes.

Autor: Chika K Onwuamah, Sabdat O Ekama, Rosemary A Audu, Oliver C Ezechi, Miriam C Poirier, Peter G C Odeigah

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90296 (2014)

Antiretroviral drugs have proved useful in the clinical management of HIV-infected persons, though there are concerns about the effects of exposure to these DNA-reactive drugs. We investigated the potential of the plant model Allium cepa root tip ass

Externí odkaz: https://doaj.org/article/f96faa0ad3634cb99678613cb0112638

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