Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Miriam Breunig"'
Autor:
Raphael Mietzner, Ramona Pawlak, Ernst R. Tamm, Achim Goepferich, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 18 (2021)
A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm’s canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the
Externí odkaz:
https://doaj.org/article/13ba8a624b6942ba8a42e5fce7a9f52b
Autor:
Tobias Sonntag, Franziska Froemel, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 901 (2021)
In glaucoma therapy, nanoparticles (NPs) are a favorable tool for delivering drugs to the outflow tissues of the anterior chamber of the eye where disease development and progression take place. In this context, a prerequisite is an efficient enrichm
Externí odkaz:
https://doaj.org/article/e109bff045a348efbff487a22e56e1fd
Autor:
David Peterhoff, Stefanie Thalhauser, Jan M. Sobczak, Mona O. Mohsen, Christoph Voigt, Nicole Seifert, Patrick Neckermann, Alexandra Hauser, Song Ding, Quentin Sattentau, Martin F. Bachmann, Miriam Breunig, Ralf Wagner
Publikováno v:
Vaccines, Vol 9, Iss 6, p 642 (2021)
The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent, durable and broad neutralizing antibody (bnAb) response. Towards that goal, we exa
Externí odkaz:
https://doaj.org/article/10e3fcc31e9c437b81c70b242bf689c0
Autor:
Raphael Mietzner, Christian Kade, Franziska Froemel, Diana Pauly, W. Daniel Stamer, Andreas Ohlmann, Joachim Wegener, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceutics, Vol 12, Iss 8, p 706 (2020)
Rho-associated protein kinase (ROCK) inhibitors allow for causative glaucoma therapy. Unfortunately, topically applied ROCK inhibitors suffer from high incidence of hyperemia and low intraocular bioavailability. Therefore, we propose the use of poly
Externí odkaz:
https://doaj.org/article/64db04ae5498400f92e112cc3cc8bf40
Autor:
Christian E. Ziegler, Moritz Graf, Makoto Nagaoka, Jonas Groner, Raphael Mietzner, Miriam Breunig, Achim M. Goepferich
Publikováno v:
Molecular Pharmaceutics. 20:2465-2476
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28c0ce97efbd20779c5ee7237062588d
https://doi.org/10.1021/acs.molpharmaceut.2c01060
https://doi.org/10.1021/acs.molpharmaceut.2c01060
Autor:
Jonas Groner, Martina Tognazzi, Melanie Walter, Daniel Fleischmann, Raphael Mietzner, Christian E. Ziegler, Achim M. Goepferich, Miriam Breunig
Publikováno v:
ACS Applied Bio Materials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234bc3699927adae67d7178a64a8252a
https://doi.org/10.1021/acsabm.2c01001
https://doi.org/10.1021/acsabm.2c01001
Autor:
David Peterhoff, Stefanie Thalhauser, Patrick Neckermann, Clara Barbey, Kristina Straub, Julian Nazet, Rainer Merkl, Gernot Laengst, Miriam Breunig, Ralf Wagner
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
Selective targeting of germline B cells with specifically designed germline-targeting HIV-1 envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit broadly neutralizing antibodies (bnAbs). BnAbs are extremely valuable bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708e9c9985fac6104ffe7c911187873
https://pubmed.ncbi.nlm.nih.gov/36272655
https://pubmed.ncbi.nlm.nih.gov/36272655
Publikováno v:
Journal of Controlled Release. 333:536-559
Atherosclerosis is the leading cause of death in developed countries. The pathogenetic mechanism relies on a macrophage-based immune reaction to low density lipoprotein (LDL) deposition in blood vessels with dysfunctional endothelia. Thus, atheroscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12682eb3ab39702fa983a4887397ec16
https://doi.org/10.1016/j.jconrel.2021.03.034
https://doi.org/10.1016/j.jconrel.2021.03.034
Autor:
Wagner, David Peterhoff, Stefanie Thalhauser, Jan M. Sobczak, Mona O. Mohsen, Christoph Voigt, Nicole Seifert, Patrick Neckermann, Alexandra Hauser, Song Ding, Quentin Sattentau, Martin F. Bachmann, Miriam Breunig, Ralf
Publikováno v:
Vaccines; Volume 9; Issue 6; Pages: 642
The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent, durable and broad neutralizing antibody (bnAb) response. Towards that goal, we exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b51217c7c70fa3711404af0008c3a687
Autor:
Miriam Breunig, Raphael Mietzner
Publikováno v:
Drug Discovery Today. 24:1606-1613
Glaucoma is one of the most common causes of blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor of the disease. Conventional therapy suffers from poor compliance, low bioavailability, and the lack of causativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea151e4e91490ae16dac7b818d058597
https://doi.org/10.1016/j.drudis.2019.03.017
https://doi.org/10.1016/j.drudis.2019.03.017