Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Miriam Bibel"'
Autor:
David Marcellin, Dorothee Abramowski, Douglas Young, Jens Richter, Andreas Weiss, Audrey Marcel, Julia Maassen, Muriel Kauffmann, Miriam Bibel, Derya R Shimshek, Richard L M Faull, Gillian P Bates, Rainer R Kuhn, P Herman Van der Putten, Peter Schmid, Gregor P Lotz
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44457 (2012)
Cleavage of the full-length mutant huntingtin (mhtt) protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the neuropathophysiology of Huntington's Disease (HD). Recent quantification studies using TR-FRET-base
Externí odkaz:
https://doaj.org/article/301db3dcf0a2450bab3b38981ddf66c9
Autor:
Paolo Paganetti, Etienne Régulier, David E. Housman, Vanita Chopra, Ruth A. Bodner, Dorothee Abramowski, Graeme Bilbe, Scott Zeitlin, Corinna Klein, Jonathan H. Fox, Kimberly B. Kegel, Marian DiFiglia, Andreas Weiss, Steven M. Hersch, Muriel Stefani, Stephan Grueninger, H. Diana Rosas, Miriam Bibel
Publikováno v:
Analytical Biochemistry. 395:8-15
The genetic mutation causing Huntington's disease is a polyglutamine expansion in the huntingtin protein where more than 37 glutamines cause disease by formation of toxic intracellular fragments, aggregates, and cell death. Despite a clear pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08369eb70968506288e76576063e5069
https://doi.org/10.1016/j.ab.2009.08.001
https://doi.org/10.1016/j.ab.2009.08.001
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
Autor:
Damaris Bausch-Fluck, Ruedi Aebersold, Ralph Schiess, Julian D. Watts, Miriam Bibel, Bernd Wollscheid, Christine Henderson, Robert V. O’Brien
Publikováno v:
Nature Biotechnology. 27:378-386
Although the classification of cell types often relies on the identification of cell surface proteins as differentiation markers, flow cytometry requires suitable antibodies and currently permits detection of only up to a dozen differentiation marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85e2ff8d03eae10e0a61a4d5207967
https://doi.org/10.1038/nbt.1532
https://doi.org/10.1038/nbt.1532
Autor:
Emmanuel Lacroix, Yves-Alain Barde, Siro Perez-Alcala, Miriam Bibel, Martin Korte, Jens Richter, Joseph Rahuel, Ulrike Müller, Katrin Schrenk-Siemens
Publikováno v:
Stem Cells. 26:2153-2163
The in vitro generation of uniform populations of neurons from mouse embryonic stem cells (ESCs) provides a novel opportunity to study gene function in neurons. This is of particular interest when mutations lead to lethal in vivo phenotypes. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ff14429a9c141bfe8ab5f54edfc544
https://doi.org/10.1634/stemcells.2008-0010
https://doi.org/10.1634/stemcells.2008-0010
Autor:
Michael Rebhan, Dirk Schübeler, Tim Roloff, Jens Richter, Michael Weber, Fabio Mohn, Miriam Bibel, Michael B. Stadler
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2008, 30 (6), pp.755-766. ⟨10.1016/j.molcel.2008.05.007⟩
Molecular Cell, Elsevier, 2008, 30 (6), pp.755-766. ⟨10.1016/j.molcel.2008.05.007⟩
Cellular differentiation entails loss of pluripotency and gain of lineage- and cell-type-specific characteristics. Using a murine system that progresses from stem cells to lineage-committed progenitors to terminally differentiated neurons, we analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7eb02fb152e49a45e36ebaeeebe3ac
https://doi.org/10.1016/j.molcel.2008.05.007
https://doi.org/10.1016/j.molcel.2008.05.007
Publikováno v:
Development. 131:5449-5456
The developmental potential of a uniform population of neural progenitors was tested by implanting them into chick embryos. These cells were generated from retinoic acid-treated mouse embryonic stem (ES) cells, and were used to replace a segment of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b7a6da499aeaf1f1ca210651c94589
https://doi.org/10.1242/dev.01420
https://doi.org/10.1242/dev.01420
Autor:
Miriam Bibel, Uwe Gosslar, Carsten Raasch, Wolfgang Liebl, Wolfgang R. Streit, Jürgen Schanzer
Publikováno v:
Extremophiles. 4:189-200
The gene for the alpha-glucosidase AglA of the hyperthermophilic bacterium Thermotoga maritima MSB8, which was identified by phenotypic screening of a T. maritima gene library, is located within a cluster of genes involved in the hydrolysis of starch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324bc3a9530aaf55d5b2f75eac9b7112
https://doi.org/10.1007/pl00010711
https://doi.org/10.1007/pl00010711
Publikováno v:
FEMS Microbiology Letters. 158:9-15
In addition to the previously identified 4-alpha-glucanotransferase gene mgtA and the alpha-amylase gene amyA of Thermotoga maritima strain MSB8 we have now isolated three further genes encoding amylolytic enzymes from a gene library of this ancestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1415bc494690d80e6b378f0a964a3597
https://doi.org/10.1111/j.1574-6968.1998.tb12793.x
https://doi.org/10.1111/j.1574-6968.1998.tb12793.x
Autor:
Miriam Bibel, Vassiliki Nikoletopoulou, Chantal Rencurel, Lixin Zhang, Yves-Alain Barde, José María Frade, Heiko Lickert, Patrizia Giallonardo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
12 páginas
Neurons of the peripheral nervous system have long been known to require survival factors to prevent their death during development. But why they selectively become dependent on secretory molecules has remained a mystery, as is the o
Neurons of the peripheral nervous system have long been known to require survival factors to prevent their death during development. But why they selectively become dependent on secretory molecules has remained a mystery, as is the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2266dcb9434b550d4fb3cd97ab3783f2
http://hdl.handle.net/10261/27437
http://hdl.handle.net/10261/27437
Autor:
Miriam Bibel
Publikováno v:
Alzheimer's & Dementia. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df92d2b2ac28511fc4cde85441bbe8d9
https://doi.org/10.1016/j.jalz.2009.05.155
https://doi.org/10.1016/j.jalz.2009.05.155