Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Miriam A. Shelef"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAnti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis, but the sources of citrullinated antigens as well as which peptidylarginine deiminases (PADs) are required for their production remain incompletely defi
Externí odkaz:
https://doaj.org/article/775a57052f284fc39ce1d8353ef9387b
Autor:
Alexandra Cîrciumaru, Marcelo Gomes Afonso, Heidi Wähämaa, Akilan Krishnamurthy, Monika Hansson, Linda Mathsson-Alm, Márton Keszei, Ragnhild Stålesen, Lars Ottosson, Charlotte de Vries, Miriam A. Shelef, Vivianne Malmström, Lars Klareskog, Anca I. Catrina, Caroline Grönwall, Aase Hensvold, Bence Réthi
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 630 (2023)
Background: Why the adaptive immune system turns against citrullinated antigens in rheumatoid arthritis (RA) and whether anti-citrullinated protein antibodies (ACPAs) contribute to pathogenesis are questions that have triggered intense research, but
Externí odkaz:
https://doaj.org/article/6999994fcf874f858a310c2f18e72d74
Autor:
Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
The peptidylarginine deiminases (PADs) and the citrullinated proteins that they generate have key roles in innate immunity and rheumatoid arthritis, an inflammatory arthritis with antibodies that target citrullinated proteins. However, the importance
Externí odkaz:
https://doaj.org/article/6fd59b6353344d72996e41b25de3b5fa
Autor:
Laura Massarenti, Christian Enevold, Dres Damgaard, Niels Ødum, Peter Garred, Morten Frisch, Miriam A. Shelef, Søren Jacobsen, Claus Henrik Nielsen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Peptidylarginine deiminases (PADs) catalyze citrullination, a post-translational modification playing a pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA). The interplay between single nucleotide polymorp
Externí odkaz:
https://doaj.org/article/6d547b8ccd094413a74d8d9718a90ea3
Autor:
Caitlyn L. Holmes, Daeun Shim, John Kernien, Chad J. Johnson, Jeniel E. Nett, Miriam A. Shelef
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
In rheumatoid arthritis, an autoimmune inflammatory arthritis, citrullinated proteins are targeted by autoantibodies and thus thought to drive disease. Neutrophil extracellular traps (NETs) are a source of citrullinated proteins and are increased in
Externí odkaz:
https://doaj.org/article/d836f480c7e741bfbc8e20dcdc85cd45
Autor:
Hui Deng, Cindy Lin, Laura Garcia-Gerique, Shuyu Fu, Zachary Cruz, Erin E. Bonner, Matthew Rosenwasser, Sridharan Rajagopal, M Naveen Sadhu, Chandru Gajendran, Mohd Zainuddin, Ramachandraiah Gosu, Dhanalakshmi Sivanandhan, Miriam A. Shelef, Brian Nam, Dan T. Vogl, Dmitry I. Gabrilovich, Yulia Nefedova
Publikováno v:
Cancer Res
Neutrophils are closely involved in the regulation of tumor progression and formation of premetastatic niches. However, the mechanisms of their involvement and therapeutic regulation of these processes remain elusive. Here, we report a critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cad0a5da98cde5fb0d1fd8f49925a4
https://doi.org/10.1158/0008-5472.can-21-4045
https://doi.org/10.1158/0008-5472.can-21-4045
Autor:
Yulia Nefedova, Dmitry I. Gabrilovich, Dan T. Vogl, Brian Nam, Miriam A. Shelef, Dhanalakshmi Sivanandhan, Ramachandraiah Gosu, Mohd Zainuddin, Chandru Gajendran, M Naveen Sadhu, Sridharan Rajagopal, Matthew Rosenwasser, Erin E. Bonner, Zachary Cruz, Shuyu Fu, Laura Garcia-Gerique, Cindy Lin, Hui Deng
Supplementary Figure from A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654950670868fe9eae5db8b5e5f414b1
https://doi.org/10.1158/0008-5472.22431864.v1
https://doi.org/10.1158/0008-5472.22431864.v1
Autor:
Yulia Nefedova, Dmitry I. Gabrilovich, Dan T. Vogl, Brian Nam, Miriam A. Shelef, Dhanalakshmi Sivanandhan, Ramachandraiah Gosu, Mohd Zainuddin, Chandru Gajendran, M Naveen Sadhu, Sridharan Rajagopal, Matthew Rosenwasser, Erin E. Bonner, Zachary Cruz, Shuyu Fu, Laura Garcia-Gerique, Cindy Lin, Hui Deng
Supplementary Data from A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a95db27a943d8b96b37085c3924cde
https://doi.org/10.1158/0008-5472.22431870.v1
https://doi.org/10.1158/0008-5472.22431870.v1
Autor:
Yulia Nefedova, Dmitry I. Gabrilovich, Dan T. Vogl, Brian Nam, Miriam A. Shelef, Dhanalakshmi Sivanandhan, Ramachandraiah Gosu, Mohd Zainuddin, Chandru Gajendran, M Naveen Sadhu, Sridharan Rajagopal, Matthew Rosenwasser, Erin E. Bonner, Zachary Cruz, Shuyu Fu, Laura Garcia-Gerique, Cindy Lin, Hui Deng
Neutrophils are closely involved in the regulation of tumor progression and formation of premetastatic niches. However, the mechanisms of their involvement and therapeutic regulation of these processes remain elusive. Here, we report a critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca9d5d586c346659e7c674b4fd0631c
https://doi.org/10.1158/0008-5472.c.6514017
https://doi.org/10.1158/0008-5472.c.6514017
Autor:
Aisha M. Mergaert, Zihao Zheng, Michael F. Denny, Maya F. Amjadi, S. Janna Bashar, Michael A. Newton, Vivianne Malmström, Caroline Grönwall, Sara S. McCoy, Miriam A. Shelef
Publikováno v:
Arthritis Rheumatol
Rheumatoid arthritis (RA) patients often develop rheumatoid factors (RFs), antibodies that bind IgG Fc, and anti-modified protein antibodies (AMPAs), multireactive autoantibodies that commonly bind citrullinated, homocitrullinated, and acetylated ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af855094c3a96f3464c1a721d6edde9
https://doi.org/10.1002/art.42064
https://doi.org/10.1002/art.42064