Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Miriam A. Hickey"'
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Publikováno v:
Cells, Vol 13, Iss 10, p 799 (2024)
Parkinson’s disease (PD) is the second-most common neurodegenerative disorder worldwide and is diagnosed based on motor impairments. Non-motor symptoms are also well-recognised in this disorder, and peripheral neuropathy is a frequent but poorly ap
Externí odkaz:
https://doaj.org/article/417000fa5f0f404c97cdf1af1cd41bb4
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
5xFAD transgenic (TG) mice are used widely in AD preclinical trials; however, data on sample sizes are largely unaddressed. We therefore performed estimates of sample sizes and effect sizes for typical behavioural and neuropathological outcome measur
Externí odkaz:
https://doaj.org/article/07f3e074ebd742eaa50ebb043c223cb3
Autor:
Toomas Jagomäe, Kadri Seppa, Riin Reimets, Marko Pastak, Mihkel Plaas, Miriam A. Hickey, Kaia Grete Kukker, Lieve Moons, Lies De Groef, Eero Vasar, Allen Kaasik, Anton Terasmaa, Mario Plaas
Publikováno v:
Cells, Vol 10, Iss 11, p 3193 (2021)
Wolfram syndrome (WS), also known as a DIDMOAD (diabetes insipidus, early-onset diabetes mellitus, optic nerve atrophy and deafness) is a rare autosomal disorder caused by mutations in the Wolframin1 (WFS1) gene. Previous studies have revealed that g
Externí odkaz:
https://doaj.org/article/baf6b0dceefa49f8af4e77d5cbd8b3b4
Publikováno v:
Biology; Volume 11; Issue 6; Pages: 938
Anxiety is a known comorbidity and risk factor for conversion to neuroinflammation-mediated dementia in patients with Alzheimer’s disease (AD). Here, we investigated if anxiety occurred as an early endophenotype of mutant familial AD (5 × FAD) mal
Autor:
Eero Vasar, Lieve Moons, Lies De Groef, Anton Terasmaa, Toomas Jagomäe, Kadri Seppa, Miriam A Hickey, Marko Pastak, Allen Kaasik, Mario Plaas, Kaia Grete Kukker, Riin Reimets, Mihkel Plaas
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 3193, p 3193 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3193, p 3193 (2021)
BackgroundWolfram syndrome (WS), also known as a DIDMOAD (Diabetes Insipidus, early-onset Diabetes Mellitus, Optic nerve Atrophy and Deafness) is a rare autosomal disorder caused by mutations in the Wolframin1 ( WFS1 ) gene. Previous studies revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866af3166e63f3cab2515be86b4387ae
https://doi.org/10.21203/rs.3.rs-903256/v1
https://doi.org/10.21203/rs.3.rs-903256/v1
Autor:
Miriam A Hickey, Jürgen Innos
Publikováno v:
Chemical research in toxicology. 34(5)
Rotenone is a naturally occurring toxin that inhibits complex I of the mitochondrial electron transport chain. Several epidemiological studies have shown an increased risk of Parkinson's disease (PD) in individuals exposed chronically to rotenone, an
Autor:
Carlo Morasso, Stella Gagliardi, Polychronis Stivaktakis, Davide Prosperi, Cecilia Pandini, Cristina Cereda, Aristides M. Tsatsakis, Miriam A Hickey, Veronica Tinelli, Fabio Corsi
Publikováno v:
Molecules, Vol 25, Iss 5389, p 5389 (2020)
Molecules
Molecules
Curcumin’s pharmacological properties and its possible benefits for neurological diseases and dementia have been much debated. In vitro experiments show that curcumin modulates several key physiological pathways of importance for neurology. However
Autor:
Mario Plaas, Mait Nigul, Tuuliki Koppel, Toomas Jagomäe, Tuuli Vallisoo, Kadri Seppa, Maarja Toots, Indrek Heinla, Eero Vasar, Andres Piirsoo, Riho Meier, Miriam A Hickey, Riin Reimets, Allen Kaasik, Anton Terasmaa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Wolfram syndrome (WS) is a rare autosomal-recessive disorder that is caused by mutations in the WFS1 gene and is characterized by juvenile-onset diabetes, optic atrophy, hearing loss and a number of other complications. Here, we describe the creation
Autor:
Miriam A Hickey, Katyayani Singh, Toomas Jagomäe, Kersti Lilleväli, Este Leidmaa, Eero Vasar, Mohan Jayaram, Michael K. E. Schäfer, Allen Kaasik, Mari-Anne Philips, Maria Kaare, Jürgen Innos, Indrek Heinla
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Neuronal growth regulator 1 (NEGR1) belongs to the immunoglobulin (IgLON) superfamily of cell adhesion molecules involved in cortical layering. Recent functional and genomic studies implicate the role of NEGR1 in a wide spectrum of psychiatric disord