Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Miriam A. Giardini"'
Autor:
Obaid Hayat, Nazif Ullah, Muhammad Sirajuddin, Miriam A. Giardini, Jennifer V. Nguyen, Karol R. Francisco, Lawrence J. Liu, Yujie Uli Sun, Svetlana Maurya, Dominic McGrosso, David J. Gonzalez, Conor R. Caffrey, Anjan Debnath, Jair L. Siqueira-Neto
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1424 (2022)
Metals have been used in medicine since ancient times for the treatment of different ailments with various elements such as iron, gold and arsenic. Metal complexes have also been reported to show antibiotic and antiparasitic activity. In this context
Externí odkaz:
https://doaj.org/article/3a11b00416ca4f92923dce5b3db08fed
Autor:
Caio H. Franco, David C. Warhurst, Tapan Bhattacharyya, Ho Y.A. Au, Hai Le, Miriam A. Giardini, Bruno S. Pascoalino, Ana Claudia Torrecilhas, Lavinia M.D. Romera, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, Michael A. Miles, Carolina B. Moraes
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 107-120 (2020)
Ergosterol biosynthesis inhibitors, such as posaconazole and ravuconazole, have been proposed as drug candidates for Chagas disease, a neglected infectious tropical disease caused by the protozoan parasite Trypanosoma cruzi. To understand better the
Externí odkaz:
https://doaj.org/article/401d5796b83843e0ab37d5b3dcd25a14
Autor:
Ittipat Meewan, Jacob Kattoula, Julius Y. Kattoula, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, James H. McKerrow, Jair Lage de Siqueira-Neto, Anthony J. O’Donoghue, Ruben Abagyan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 744 (2022)
One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against three key
Externí odkaz:
https://doaj.org/article/657345c2310e45a7868c20618d38774e
Autor:
Lucianna H. Santos, Thales Kronenberger, Renata G. Almeida, Elany B. Silva, Rafael E. O. Rocha, Joyce C. Oliveira, Luiza V. Barreto, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, Conner Bardine, André L. Lourenço, Charles S. Craik, Antti Poso, Larissa M. Podust, James H. McKerrow, Jair L. Siqueira-Neto, Anthony J. O’Donoghue, Eufrânio N. da Silva Júnior, Rafaela S. Ferreira
Publikováno v:
Journal of Chemical Information and Modeling. 62:6553-6573
Autor:
John A. Kavouris, Laura-Isobel McCall, Miriam A. Giardini, Geraldine De Muylder, Diane Thomas, Adolfo Garcia-Pérez, Juan Cantizani, Ignacio Cotillo, Jose M. Fiandor, James H. McKerrow, Camila I. De Oliveira, Jair L. Siqueira-Neto, Silvia González, Lauren E. Brown, Scott E. Schaus
Publikováno v:
Front Trop Dis
IntroductionLeishmaniasis is a parasitic disease that affects more than 1 million people worldwide annually, predominantly in resource-limited settings. The challenge in compound development is to exhibit potent activity against the intracellular sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca89de57925ec53ca70b886fe99830eb
https://europepmc.org/articles/PMC9937549/
https://europepmc.org/articles/PMC9937549/
Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes
Autor:
Johannes Karges, Miriam A. Giardini, Olivier Blacque, Brendon Woodworth, Jair L. Siqueira-Neto, Seth M. Cohen
Publikováno v:
Chemical science, vol 14, iss 3
Infections of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have triggered a global pandemic with millions of deaths worldwide. Herein, the synthesis of functionalized Re(i) tricarbonyl complexes as inhibitors of the SARS-CoV-2 mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316679b7871bf1be4aa2aa5bc87f9e77
Autor:
Jéssica Alves Nunes, Fabrícia Nunes da Silva, Elany Barbosa da Silva, Clara Andrezza Crisóstomo Bezerra Costa, Johnnatan Duarte de Freitas, Francisco Jaime Bezerra Mendonça-Junior, Miriam Aparecida Giardini, Jair Lage de Siqueira-Neto, James H. McKerrow, Thaiz Rodrigues Teixeira, Louis William Odeesho, Conor R. Caffrey, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior
Publikováno v:
New Journal of Chemistry.
Trypanosoma cruzi (Chagas diseases – also named American trypanosomiasis) and T. brucei (human African trypanosomiasis – HAT) negatively impact public health, being endemic in several countries and leading to thousands of deaths per year.
Autor:
Aleksandra Drelich, Miriam A. Giardini, Pavla Fajtová, Drake M. Mellott, Vivian Hook, Thomas D. Meek, Jason C. Hsu, Demetrios H. Kostomiris, Aaron F. Carlin, Frank M. Raushel, Klaudia I. Kocurek, Jair L. Siqueira-Neto, Zane W. Taylor, Anthony J. O’Donoghue, Felix W Frueh, Jiyun Zhu, Ardala Katzfuss, Chien Te K. Tseng, Sungjun Beck, Hong Wang, Brett L. Hurst, Laura Beretta, Ken Hirata, James H. McKerrow, Alex E. Clark, Linfeng Li, Daniel C Maneval, Danielle E. Skinner, Balachandra Chenna, Vivian Tat, Michael C Yoon
Publikováno v:
ACS Chemical Biology. 16:642-650
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SAR
Autor:
Miriam A. Giardini, Pavla Fajtová, Jair L. Siqueira-Neto, Julius Y. Kattoula, Jacob Kattoula, Brendon Woodworth, Anthony J. O’Donoghue, Ruben Abagyan, Ittipat Meewan, James H. McKerrow, Danielle E. Skinner
There are currently no FDA approved inhibitors of SARS-CoV-2 viral proteases with specific treatment for post-exposure of SARS-CoV-2. Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against three key prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6136bd851ab68b98475f4d3da0d5744c
https://doi.org/10.1101/2021.10.19.465036
https://doi.org/10.1101/2021.10.19.465036
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote