Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Miriam, Wöhner"'
Autor:
Miriam Wöhner, Sarah Brechtelsbauer, Niklas Friedrich, Christof Vorsatz, Johanna Bulang, Chunguang Liang, Lena Schorr, Alain Beschin, Martin Guilliams, Jeffrey Ravetch, Falk Nimmerjahn, Markus Biburger
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113757- (2024)
Summary: Understanding the mechanisms underlying cytotoxic immunoglobulin G (IgG) activity is critical for improving therapeutic antibody activity and inhibiting autoantibody-mediated tissue pathology. While prior research highlights the important ro
Externí odkaz:
https://doaj.org/article/654bceaf63c342158e7b7f4bd4847ced
Autor:
Miriam Wöhner, Theresa Pinter, Peter Bönelt, Astrid Hagelkruys, Daniela Kostanova-Poliakova, Johannes Stadlmann, Stephen F. Konieczny, Maria Fischer, Markus Jaritz, Meinrad Busslinger
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the transcription factor Xbp1. Here, we analyz
Externí odkaz:
https://doaj.org/article/3cc0753e9f5d4decbd571668ede0afff
Autor:
Theresa Pinter, Maria Fischer, Markus Schäfer, Michaela Fellner, Julian Jude, Johannes Zuber, Meinrad Busslinger, Miriam Wöhner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Plasma cells (PCs) and their progenitors plasmablasts (PBs) are essential for the acute and long-term protection of the host against infections by providing vast levels of highly specific antibodies. Several transcription factors, like Blimp1 and Irf
Externí odkaz:
https://doaj.org/article/cf9402de4b674a81b7d184f584548fe3
Autor:
Michaela Seeling, Matthias Pöhnl, Sibel Kara, Nathalie Horstmann, Carolina Riemer, Miriam Wöhner, Chunguang Liang, Christin Brückner, Patrick Eiring, Anja Werner, Markus Biburger, Leon Altmann, Martin Schneider, Lukas Amon, Christian H.K. Lehmann, Sooyeon Lee, Meik Kunz, Diana Dudziak, Georg Schett, Tobias Bäuerle, Anja Lux, Jan Tuckermann, Timo Vögtle, Bernhardt Nieswandt, Markus Sauer, Rainer A. Böckmann, Falk Nimmerjahn
Immunoglobulin G (IgG) antibodies are major drivers of inflammation during infectious and autoimmune diseases. In pooled serum IgG (IVIg), however, antibodies have a potent immunomodulatory and anti-inflammatory activity, but how this is mediated is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1351f723d8fef785ccb450d337d55549
https://publica.fraunhofer.de/handle/publica/441501
https://publica.fraunhofer.de/handle/publica/441501
Autor:
Kenneth M. Murphy, Gary E. Grajales-Reyes, Rodney D. Newberry, Carlos G. Briseño, Prachi Bagadia, Howard Y. Chang, Theresa L. Murphy, Vivek Durai, Swapneel J. Patel, Xiao Huang, Hiromi Tagoh, Jeffrey M. Granja, Miriam Wöhner, Jesse T. Davidson, Barbara L. Kee, Ansuman T. Satpathy, Tian Tian Liu, Renee Wu, Meinrad Busslinger, Arifumi Iwata, Devesha H. Kulkarni
Publikováno v:
Nature immunology
Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ef9c16706916c827ba8c303855412c
http://europepmc.org/articles/PMC6707878
http://europepmc.org/articles/PMC6707878
Autor:
Grace J Liu, Meinrad Busslinger, Andreas Bergthaler, Stephen Malin, Markus Jaritz, Miriam Wöhner, Benedikt Agerer
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine
Due to cross-antagonism of the B cell factor Pax5 and plasma cell regulator Blimp1, it was hypothesized that plasma cells develop only upon Pax5 repression by Blimp1. Unexpectedly, Liu et al. show that ectopic Pax5 expression in plasma cells does not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7130c971a6ef647a0093bff8fb20ebc
http://europepmc.org/articles/PMC7596824
http://europepmc.org/articles/PMC7596824
Autor:
Luigi Tortola, Rubina Koglgruber, Gerald Wirnsberger, Christoph Klein, Miriam Wöhner, Melanie Kogler, Meinrad Busslinger, Josef M. Penninger, Astrid Hagelkruys, Johannes Stadlmann, Maria Novatchkova, David Hoffmann, Andreas Bergthaler, Georg Schett, Bojan Vilagos, Marion Horrer, Peter Bönelt, Gustav Jonsson, Ulrike Steffen
Publikováno v:
The Journal of Experimental Medicine
Jagn1 deficiency results in alterations in the endoplasmic reticulum (ER) and Golgi apparatus of antibody-producing cells, reduced antibody secretion, and aberrant IgG N-glycosylation. The data uncover a key role for JAGN1 and ER stress in antibody g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035ce1e26b0e1bac78990b6f7111f245
https://pubmed.ncbi.nlm.nih.gov/32930709
https://pubmed.ncbi.nlm.nih.gov/32930709
Autor:
Meinrad Busslinger, Anoop Kavirayani, Miriam Wöhner, Manasa G. Garimella, Maria Fischer, Peter Bönelt, Markus Jaritz, Mikael C. I. Karlsson, Hiromi Tagoh, Martina Minnich
Publikováno v:
The EMBO Journal
The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease in humans. Here, we demonstrate in the mouse that the Prdm1 (Blimp1) gene was partially activated at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9974bfcfc03d84b4ecfa260bc39d47
https://doi.org/10.15252/embj.2018100010
https://doi.org/10.15252/embj.2018100010
Autor:
Reshma Taneja, Moritz J. Rossner, Meinrad Busslinger, Taras Kreslavsky, Daniela Kostanova Poliakova, Markus Jaritz, Hiromi Tagoh, Bojan Vilagos, Siegfried Weiss, Tanja A. Schwickert, Miriam Wöhner
Publikováno v:
Nature Immunology. 18:442-455
Innate-like B-1a cells provide a first line of defense against pathogens, yet little is known about their transcriptional control. Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637c4e206dc32767cc9211c9f63bcbbf
https://doi.org/10.1038/ni.3694
https://doi.org/10.1038/ni.3694
Autor:
Palasch C. Maity, Miriam Wöhner, Carolin Brandl, Sieglinde Angermüller, Ingrid Obermeier, Michael Reth, Sarah Mrotzek, Lars Nitschke, Jennifer Müller
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12402-12407
A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870a4157d44dbcdaa855958d7835011c
https://doi.org/10.1073/pnas.1304888110
https://doi.org/10.1073/pnas.1304888110