Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Miriam, Stoeber"'
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Autor:
Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A. Bhat, Ananya S. Achanta, Joseph C. Johnson, Amanda Loren Pasqualini, Sanjana Jadhav, Corinna A. Bauder, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Azra Suko, Richard D. Palmiter, Miriam Stoeber, Peter Kloppenburg, Jens C. Brüning, Michael R. Bruchas, Tommaso Patriarchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action
Externí odkaz:
https://doaj.org/article/85f93020cae0443ca2de0481924bf37c
Autor:
Reto B Cola, Salome N Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq A Bhat, Kevin Assoumou, Elyse T Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke, Miriam Stoeber, Gil Levkowitz, Sarah Melzer, Tommaso Patriarchi
Publikováno v:
eLife, Vol 13 (2024)
Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1P78A, a novel genetically e
Externí odkaz:
https://doaj.org/article/83a204a88f8b464d90811cb0b5e39796
Autor:
Miriam Stoeber, Damien Jullié, Joy Li, Soumen Chakraborty, Susruta Majumdar, Nevin A Lambert, Aashish Manglik, Mark von Zastrow
Publikováno v:
eLife, Vol 9 (2020)
G protein-coupled receptors (GPCRs) signal through allostery, and it is increasingly clear that chemically distinct agonists can produce different receptor-based effects. It has been proposed that agonists selectively promote receptors to recruit one
Externí odkaz:
https://doaj.org/article/8c895244c98b40adb73cdb12ae8fea95
Development of a genetically-encoded sensor for probing endogenous nociceptin opioid peptide release
Autor:
Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A Bhat, Ananya S. Achanta, Joseph C Johnson, Sanjana Jadhav, Corinna A Bader, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Miriam Stoeber, Peter Kloppenburg, Jens Claus Bruening, Michael R Bruchas, Tommaso Patriarchi
Publikováno v:
bioRxiv
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e2c8ec895fdbf0b6b240626d49745f
https://europepmc.org/articles/PMC10245933/
https://europepmc.org/articles/PMC10245933/
Autor:
Arthur Radoux-Mergault, Lucie Oberhauser, Simone Aureli, Francesco Luigi Gervasio, Miriam Stoeber
G protein-coupled receptors in intracellular organelles can be activated in response to membrane permeant ligands, which contributes to the diversity and specificity of agonist action. The opioid receptors (ORs) provide a striking example, where opio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4336de54f9aecbf7b2de465fc5be4f9d
https://doi.org/10.1101/2022.12.12.520050
https://doi.org/10.1101/2022.12.12.520050
Autor:
Guoqing, Xiang, Amanda, Acosta-Ruiz, Arthur, Radoux-Mergault, Melanie, Kristt, Jihye, Kim, Jared D, Moon, Johannes, Broichhagen, Asuka, Inoue, Francis S, Lee, Miriam, Stoeber, Jeremy S, Dittman, Joshua, Levitz
Publikováno v:
Science advances. 8(47)
Numerous processes contribute to the regulation of G protein-coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal t
Autor:
Guoqing Xiang, Amanda Acosta-Ruiz, Arthur Radoux-Mergault, Melanie Kristt, Jihye Kim, Jared D. Moon, Johannes Broichhagen, Asuka Inoue, Francis S. Lee, Miriam Stoeber, Jeremy S. Dittman, Joshua Levitz
Publikováno v:
Science Advances. 8
Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal
Autor:
Lucie, Oberhauser, Miriam, Stoeber
Publikováno v:
Handbook of experimental pharmacology. 271
The kappa opioid receptor (KOR) has emerged as a promising therapeutic target for pain and itch treatment. There is growing interest in biased agonists that preferentially activate select signaling pathways downstream of KOR activation on the cellula
Autor:
Miriam, Stoeber
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2169
Protein-protein and protein-lipid interactions play important roles in the assembly of protein coats that regulate membrane organization, signaling, and trafficking in eukaryotic cells. Caveolae are plasma membrane invaginations that are formed by a
Autor:
André Schmitz, Alexandra Schwarz, Michael Foss, Lixin Zhou, Birgit Rabe, Julia Hoellenriegel, Miriam Stoeber, Nelly Panté, Michael Kann
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000741 (2010)
Virtually all DNA viruses including hepatitis B viruses (HBV) replicate their genome inside the nucleus. In non-dividing cells, the genome has to pass through the nuclear pore complexes (NPCs) by the aid of nuclear transport receptors as e.g. importi
Externí odkaz:
https://doaj.org/article/f066420f2cb940798d0f0408a472e63b