A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

Autor: Marito Hayashi, Miriam Gullo, Gokhan Senturk, Stefania Di Costanzo, Shinji C. Nagasaki, Ryoichiro Kageyama, Itaru Imayoshi, Martyn Goulding, Samuel L. Pfaff, Graziana Gatto

Publikováno v: bioRxiv

Innate and goal-directed movements require a high-degree of trunk and appendicular muscle coordination to preserve body stability while ensuring the correct execution of the motor action. The spinal neural circuits underlying motor execution and post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22efbdf050ca82c8fd92c892c8a90c84
https://europepmc.org/articles/PMC10055247/

The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.

Autor: Anissa Kempf, Bjoern Tews, Michael E Arzt, Oliver Weinmann, Franz J Obermair, Vincent Pernet, Marta Zagrebelsky, Andrea Delekate, Cristina Iobbi, Ajmal Zemmar, Zorica Ristic, Miriam Gullo, Peter Spies, Dana Dodd, Daniel Gygax, Martin Korte, Martin E Schwab

Publikováno v: PLoS Biology, Vol 12, Iss 1, p e1001763 (2014)

Nogo-A is a membrane protein of the central nervous system (CNS) restricting neurite growth and synaptic plasticity via two extracellular domains: Nogo-66 and Nogo-A-Δ20. Receptors transducing Nogo-A-Δ20 signaling remained elusive so far. Here we i

Externí odkaz: https://doaj.org/article/bf0435eb427c4707b9e3fffb96f095d4

Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position

Autor: Marito Hayashi, Miriam Gullo, Rudolf Grosschedl, Terumi Kohwi-Shigematsu, Shawn P. Driscoll, Jessica M. Montgomery, Kathryn L. Hilde, Ariel J. Levine, Yoshinori Kohwi, Christopher A. Hinckley, Samuel L. Pfaff

Publikováno v: Neuron

Motor behaviors such as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensory circuitry to generate appropriate muscle activation patterns. Both the cellular components and the molecular mechanisms that inst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb684875b055ff7a601050a08290366
https://doi.org/10.1016/j.neuron.2016.07.014

Bridging the Gap: A Reticulo-Propriospinal Detour Bypassing an Incomplete Spinal Cord Injury

Autor: Regula Schneider, Hansjörg Kasper, Oliver Weinmann, Anne K. Engmann, Timoleon Moraitis, Linard Filli, Miriam Gullo, Björn Zörner, Martin E. Schwab

Publikováno v: The Journal of Neuroscience. 34:13399-13410

Anatomically incomplete spinal cord injuries are often followed by considerable functional recovery in patients and animal models, largely because of processes of neuronal plasticity. In contrast to the corticospinal system, where sprouting of fibers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecac13b63b116dba54c15478b54bc3b3
https://doi.org/10.1523/jneurosci.0701-14.2014

Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo

Autor: Yves Kellner, Karin Lussi, Raul Vicente, Ajmal Zemmar, Andreas R. Luft, Oliver Weinmann, Marta Zagrebelsky, Yi Zuo, Miriam Gullo, Mengia Rioult-Pedotti, Martin E. Schwab, Hansjörg Kasper, Zorica Ristic, Xinzhu Yu

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 26
Journal of Neuroscience

The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce1148fd9d23174cca5483bb7975fa